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https://observatorio.fm.usp.br/handle/OPI/40765
Title: | Expression of matrix metalloproteinases and their inhibitors at the implantation site in ampullary ectopic pregnancies |
Authors: | GOMEZ, Ursula Trovato; BRIZOT, Maria de Lourdes; PEREIRA, Pedro Paulo; RODRIGUES, Agatha Sacramento; SCHULTZ, Regina; HOSHIDA, Mara Sandra; FRANCISCO, Rossana Pulcineli Vieira; CABAR, Fabio Roberto |
Citation: | JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, v.50, n.5, article ID 102096, 5p, 2021 |
Abstract: | Objective: This study investigated the qualitative and semi-quantitative expression of metalloproteinases (MMP) and their tissue inhibitors (TIMP) in trophoblastic tissue during ampullary ectopic pregnancies and correlated that expression with the degree of tubal invasion. Study design: It is a prospective study that included 34 patients diagnosed with ampullary tubal pregnancy who underwent salpingectomy. A histological evaluation of the depth of trophoblastic invasion in the tubes obtained was performed. Subsequently, the expression of the MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 and TIMP-3 markers was qualitatively and semi-quantitatively evaluated by indirect immunohistochemistry. In addition, the degree of trophoblastic invasion was correlated with the expression of each marker and with the metalloproteinase/inhibitor ratios. Results: MMP-2 (11.2 %; 3.6-17.9) was the marker with greater expression at the implantation site, both in the qualitative and semi-quantitative assessment, while MMP-9 (2.23 %; 0.2-5.4) and TIMP-3 (2.53 %; 0.1-15.3) were only weakly expressed. Conclusion: There was wide variation in expression among the markers and metalloproteinase/inhibitor ratios studied compared to the degrees of invasion. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOG Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/14 Artigos e Materiais de Revistas Científicas - LIM/57 |
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