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https://observatorio.fm.usp.br/handle/OPI/40972
Title: | Metagenomic next-generation sequencing (mNGS) for diagnostically challenging infectious diseases in patients with acute leukemia |
Authors: | GARNICA, Marcia; PIERROTTI, Ligia Camera; OLIVEIRA, Paula Vanessa de; MAZZI, Mariana; CHEBABO, Alberto |
Citation: | BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, v.25, n.2, article ID 101548, 4p, 2021 |
Abstract: | This report shows the contribution of next-generation metagenomic sequencing (mNGS) as an alternative to challenging diagnostic infection in immunosuppressed individuals. Herein, we report three acute leukemia patients who developed severe invasive infections due to different etiologies: fungi, viruses, and protozoa. mNGS improved the diagnosis of the infections and provided the opportunity for adequate therapy. The mNGS is a hypothesis-free diagnostic platform, increasing potential in challenging diseases in hematological patients due to the extended diagnostic panel and the expedite access to the result. (C) 2021 Sociedade Brasileira de Infectologia. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/47 Artigos e Materiais de Revistas Científicas - ODS/03 |
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