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Title: Index of alpha/theta ratio of the electroencephalogram: a new marker for Alzheimer's disease
Authors: SCHMIDT, Magali T.KANDA, Paulo A. M.BASILE, Luis F. H.LOPES, Helder Frederico da SilvaBARATHO, ReginaDEMARIO, Jose L. C.JORGE, Mario S.NARDI, Antonio E.MACHADO, SergioIANOF, Jessica N.NITRINI, RicardoANGHINAH, Renato
Citation: FRONTIERS IN AGING NEUROSCIENCE, v.5, article ID 60, 6p, 2013
Abstract: Objective: We evaluated quantitative EEG measures to determine a screening index to discriminate Alzheimers disease (AD) patients from normal individuals. Methods: Two groups of individuals older than 50 years, comprising a control group of 57 normal volunteers and a study group of 50 patients with probable AD, were compared. EEG recordings were obtained from subjects in a wake state with eyes closed at rest for 30 min. Logistic regression analysis was conducted. Results: Spectral potentials of the alpha and theta bands were computed for all electrodes and the alpha/theta ratio calculated. Logistic regression of alpha/theta of the mean potential of the C3 and O1 electrodes was carried out. A formula was calculated to aid the diagnosis of AD yielding 76.4% sensitivity and 84.6% specificity for AD with an area under the ROC curve of 0.92. Conclusion: Logistic regression of alpha/theta of the spectrum of the mean potential of EEG represents a good marker discriminating AD patients from normal controls.
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Artigos e Materiais de Revistas Científicas - FM/MNE
Departamento de Neurologia - FM/MNE

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/15
LIM/15 - Laboratório de Investigação em Neurologia

Artigos e Materiais de Revistas Científicas - LIM/22
LIM/22 - Laboratório de Patolologia Cardiovascular

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