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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorGALLUCCI-NETO, Jose-
dc.contributor.authorBRUNONI, Andre Russowsky-
dc.contributor.authorONO, Carla Rachel-
dc.contributor.authorFIORE, Lia Arno-
dc.contributor.authorCASTRO, Luiz Henrique Martins-
dc.contributor.authorMARCHETTI, Renato Luiz-
dc.identifier.citationJOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY, v.62, n.1, p.29-37, 2021-
dc.description.abstractBackground: Psychogenic nonepileptic seizures (PNES) are a common and debilitating problem in patients with epilepsy. They can be virtually indistinguishable from epileptic seizures, demanding video-electroencaphalogram monitoring, which is costly and not widely available, for differential diagnosis. Specific functional brain correlates of PNES have not been demonstrated so far. We hypothesized that PNES and epileptic seizures have distinct brain activation patterns, assessed by functional neuroimaging during ictal events of both conditions. Objective: Compare ictal brain activation patterns of PNES and epileptic seizures using single-photon emission computerized tomography. Methods: We prospectively assessed brain functional activation using single-photon emission computerized tomography 99mTc-ethyl cysteinate dimer in 26 patients with PNES, confirmed by trained psychiatrists in epileptology, who had their seizures induced by provocative tests compared with 22 age- and sex-matched subjects with temporal lobe epilepsy who underwent prolonged intensive video-electroencaphalogram monitoring. Results: In PNES patients compared with temporal lobe epilepsy group, we found a consistent increase in regional cerebral blood flow in the right precuneus (Brodmann area 7; P = 0.003) and right posterior cingulate cortex (Brodmann area 31; P = 0.001), as well as a decrease in regional cerebral blood flow in the right amygdala (P = 0.027). Conclusions: Activation of default mode network brain areas and temporoparietal junction may be a distinct feature of ictal PNES and could be explained by a disruption between movement prediction input and sensory outcome. Such information mismatch might be the neurobiological underpinning of dissociative episodes.eng
dc.description.sponsorshipSelo Paulo Research State Foundation [FAPESP 2018/10861-7]-
dc.description.sponsorshipBrazilian National Council of Scientific Development-
dc.description.sponsorshipUniversity of Selo Paulo Medical School productivity support (PIPAA)-
dc.relation.ispartofJournal of the Academy of Consultation-Liaison Psychiatry-
dc.subjecttemporal lobe epilepsyeng
dc.subjectfunctional neurological disordereng
dc.subjectconversion disordereng
dc.titleIctal SPECT in Psychogenic Nonepileptic and Epileptic Seizureseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.type.categoryoriginal articleeng
hcfmusp.publisher.cityNEW YORKeng
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MNE
Departamento de Neurologia - FM/MNE

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/IPq
Instituto de Psiquiatria - HC/IPq

Artigos e Materiais de Revistas Científicas - LIM/27
LIM/27 - Laboratório de Neurociências

Artigos e Materiais de Revistas Científicas - LIM/43
LIM/43 - Laboratório de Medicina Nuclear

Artigos e Materiais de Revistas Científicas - LIM/45
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica

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