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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorGOMES, Regina Celia Teixeira-
dc.contributor.authorMAIORAL, Gabriela Carolina Carozi Cristofani-
dc.contributor.authorVERNA, Carina-
dc.contributor.authorPATRIARCA, Marisa Teresinha-
dc.contributor.authorNADER, Helena Bonciani-
dc.contributor.authorSIMOES, Ricardo Santos-
dc.contributor.authorBARACAT, Edmund Chada-
dc.contributor.authorSOARES JR., Jose Maria-
dc.identifier.citationFERTILITY AND STERILITY, v.100, n.5, p.1419-1427.e1, 2013-
dc.description.abstractObjective: To evaluate the effects of hyperprolactinemia on the sulfated glycosaminoglycans (GAGs) of the murine uterus. Design: Experimental research. Setting: University biochemistry laboratory. Animal(s): Eighty female mice were divided into two groups of 40 animals each and treated with 0.2 mL of saline solution (controls, Ctr) and 200 mu g of metoclopramide (experimental, HPrl). Treatments lasted for 50 consecutive days. The animals were divided into four subgroups of 10 animals each per treatment (Ctr and HPrl) and sacrificed according to the phase of the estrous cycle. The uterine horns were removed for biochemical analyses, and blood samples were collected for hormone measurements. Intervention(s): Induced hyperprolactinemia. Main Outcome Measure(s): To quantify the sulfated GAGs, and PRL and sex steroid levels. Result(s): The endometrium during the estrus phase was significantly thicker in the HPrl animals than in the Ctr mice. The levels of chondroitin and dermatan sulfate were significantly increased in the HPrl group than in the Ctr group during all phases except metestrus. The amounts of heparan sulfate were lower during estrus and diestrus and higher in the metestrus phase in HPrl than in Ctr animals. Serum PRL levels were increased whereas the levels of E-2 and P were decreased in all phases in the HPrl group than in the Ctr group. Conclusion(s): The hyperprolactinemia changed the amounts of uterine sulfated GAGs. Our data suggest that these changes may not be correlated with ovarian steroid levels. (C)2013 by American Society for Reproductive Medicine.-
dc.description.sponsorshipState of Sao Paulo Research Foundation (FAPESP) [2006/50639-3]-
dc.description.sponsorshipNational Council of Scientific and Technological Development of Brazil (CNPq) [142707/2007-4]-
dc.relation.ispartofFertility and Sterility-
dc.subjectEstrous cycle-
dc.titleHyperprolactinemia changes the sulfated glycosaminoglycan amount on the murine uterus during the estrous cycle-
dc.rights.holderCopyright ELSEVIER SCIENCE INC-
dc.subject.wosObstetrics & Gynecology-
dc.subject.wosReproductive Biology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Regina Celia Teixeira:Univ Sao Paulo, Fac Med, Dept Gynecol, Sao Paulo, Brazil-, Gabriela Carolina Carozi Cristofani:Univ Sao Paulo, Fac Med, Dept Gynecol, Sao Paulo, Brazil-, Carina:Univ Sao Paulo, Fac Med, Dept Gynecol, Sao Paulo, Brazil-, Marisa Teresinha:Univ Sao Paulo, Fac Med, Dept Gynecol, Sao Paulo, Brazil-, Helena Bonciani:Univ Sao Paulo, Fac Med, Dept Biochem, Div Mol Biol, Sao Paulo, Brazil-
hcfmusp.publisher.cityNEW YORK-
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Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular

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