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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorZUCCHI, Eliana Miura
dc.contributor.authorCOUTO, Marcia Thereza
dc.contributor.authorCASTELLANOS, Marcelo
dc.contributor.authorDUMONT-PENA, Erica
dc.contributor.authorFERRAZ, Dulce
dc.contributor.authorPINHEIRO, Thiago Felix
dc.contributor.authorGRANGEIRO, Alexandre
dc.contributor.authorSILVA, Luis Augusto Vasconcelos da
dc.contributor.authorDOURADO, Ines
dc.contributor.authorPEDRANA, Leo
dc.contributor.authorSANTOS, Fernanda Soares de Resende
dc.contributor.authorMAGNO, Laio
dc.identifier.citationPLOS ONE, v.16, n.5, article ID e0249293, 20p, 2021
dc.description.abstractBackground Adolescents face socio-structural, personal and programmatic barriers to HIV prevention services, highlighting the importance of understanding knowledge and acceptability as essential aspects to promote their broader access to pre-exposure prophylaxis (PrEP). We analyzed the acceptability of PrEP among adolescent men who have sex with men (MSM), travestis and transgender women (TGW). Methods A qualitative investigation was conducted as part of the formative research of the PrEP15-19 study, an ongoing demonstration study that analyzes the effectiveness of daily PrEP among adolescent MSM, travestis and TGW aged 15-19 in three Brazilian cities. A total of 37 semi-structured interviews and 6 focus groups were conducted. Building from thematic analysis focusing on participants' sexual encounters, perceptions about PrEP efficacy, and vulnerability contexts, we analyzed prospective acceptability of PrEP. Findings Knowledge about PrEP was incipient and characterized by adolescents' frequent doubts about its prescription and efficacy. The 'ideal' use of PrEP appeared together with consistent condom use, especially in casual sex. PrEP use was also mentioned as depending on increased learning about prevention management over time. Main barriers to PrEP use included the incorporation of a daily medication into participants' routine and its impact on their social lives, especially related to stigma. Concerns over short- and long-term side effects were also reported as barriers to PrEP use. TGW and travestis contrasted using PrEP with the precarity of their life conditions, and some expressed a critical vision about PrEP by associating it with pharmaceuticalization and trans necropolitics. Conclusions Participants' low knowledge and acceptability of PrEP are circumscribed by a rigid perception of condom as the ideal prevention method and the context of their sexual relations. Prospective acceptability highlights that the successful uptake of PrEP depends on overcoming barriers of access to health services and confronting transphobia and homophobia as part of care.eng
dc.description.sponsorshipUnitaid [2017-15-FIOTECPrEP]
dc.description.sponsorshipBrazilian Ministry of Health, through the Department of Chronic Diseases and Sexually Transmitted Infections, Bahia State Department of Health, Sao Paulo State and City Department of Health
dc.description.sponsorshipCity of Sao Paulo AIDS Program
dc.relation.ispartofPlos One
dc.subject.otherhiv preventioneng
dc.titleAcceptability of daily pre-exposure prophylaxis among adolescent men who have sex with men, travestis and transgender women in Brazil: A qualitative studyeng
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCEeng
dc.subject.wosMultidisciplinary Scienceseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Eliana Miura:Univ Catolica Santos, Programa Posgrad Saude Colet, Psicol & Polit Publ, Santos, SP, Brazil, Marcelo:Univ Fed Bahia, Inst Saude Colet, Salvador, BA, Brazil, Erica:Univ Fed Minas Gerais, Dept Enfermagem Materno Infantil & Saude Publ, Belo Horizonte, MG, Brazil, Dulce:Fundacao Oswaldo Cruz, Escola FIOCRUZ Governo, Brasilia, DF, Brazil, Luis Augusto Vasconcelos da:Univ Fed Bahia, Inst Humanidades Artes & Ciencias, Salvador, BA, Brazil, Ines:Univ Fed Bahia, Inst Saude Colet, Salvador, BA, Brazil, Leo:Univ Fed Bahia, Inst Saude Colet, Salvador, BA, Brazil, Fernanda Soares de Resende:Univ Fed Minas Gerais, Programa Posgrad Enfermagem, Belo Horizonte, MG, Brazil, Laio:Univ Fed Bahia, Inst Saude Colet, Salvador, BA, Brazil; Univ Estado Bahia, Dept Ciencias Vida, Salvador, BA, Brazil
hcfmusp.publisher.citySAN FRANCISCOeng
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Artigos e Materiais de Revistas Científicas - FM/MPR
Departamento de Medicina Preventiva - FM/MPR

Artigos e Materiais de Revistas Científicas - LIM/38
LIM/38 - Laboratório de Epidemiologia e Imunobiologia

Artigos e Materiais de Revistas Científicas - LIM/39
LIM/39 - Laboratório de Processamento de Dados Biomédicos

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

Artigos e Materiais de Revistas Científicas - ODS/05
ODS/05 - Igualdade de gênero

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