Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/4176
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorDIAS, Cacilda Rosa Barbosa-
dc.contributor.authorLEITE, Heitor Pons-
dc.contributor.authorNOGUEIRA, Paulo Cesar Koch-
dc.contributor.authorCARVALHO, Werther Brunow de-
dc.date.accessioned2014-01-28T22:25:57Z-
dc.date.available2014-01-28T22:25:57Z-
dc.date.issued2013-
dc.identifier.citationJOURNAL OF CRITICAL CARE, v.28, n.5, p.810-815, 2013-
dc.identifier.issn0883-9441-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/4176-
dc.description.abstractPurpose: The purpose was to determine the frequency and risk factors of ionized hypocalcemia and to evaluate this disturbance as a predictor of mortality in a pediatric intensive care unit (ICU). Materials and Methods: In a prospective cohort study, 337 children admitted consecutively to an ICU were monitored regarding serum ionized calcium concentrations during the first 10 days of admission. The following variables were analyzed as independent of hypocalcemia: age; malnutrition; sepsis; Pediatric Index of Mortality 2; first 3 days organ dysfunction score (Pediatric Logistic Organ Dysfunction); and use of steroids, furosemide, and anticonvulsants. Hypocalcemia was defined as a serum ionized calcium concentration less than 1.15 mmol/L. Results: The rate of hypocalcemia was 77.15%. In a multivariate model, higher Pediatric Logistic Organ Dysfunction scores during the first 3 days of ICU stay were independently associated with hypocalcemia (odds ratio, 2.24; 95% confidence interval, 1.23-4.07; P = .008). Medications associated with hypocalcemia were furosemide (dose >= 2 mg/[kg d]) and methylprednisolone (dose >= 2 mg/[kg d]). No significant association was found between hypocalcemia and 10-day mortality. Conclusions: Ionized hypocalcemia is common during the ICU stay, particularly in the first 3 days of admission. This disturbance was not found to be a predictor of mortality, but it is independently associated with more severe organ dysfunction.-
dc.language.isoeng-
dc.publisherW B SAUNDERS CO-ELSEVIER INC-
dc.relation.ispartofJournal of Critical Care-
dc.rightsrestrictedAccess-
dc.subjectHypocalcemia-
dc.subjectIntensive care unit-
dc.subjectPediatric-
dc.subjectMultiple organ failure-
dc.subjectFurosemide-
dc.subjectSteroids-
dc.subject.othercritically-ill-
dc.subject.othercritical illness-
dc.subject.othercalcium-
dc.subject.othersepsis-
dc.subject.otherabnormalities-
dc.subject.otherprevalence-
dc.subject.othermanagement-
dc.subject.othermortality-
dc.titleIonized hypocalcemia is an early event and is associated with organ dysfunction in children admitted to the intensive care unit-
dc.typearticle-
dc.rights.holderCopyright W B SAUNDERS CO-ELSEVIER INC-
dc.identifier.doi10.1016/j.jcrc.2013.03.019-
dc.identifier.pmid23683566-
dc.subject.wosCritical Care Medicine-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalDIAS, Cacilda Rosa Barbosa:Univ Fed Sao Paulo, Dept Pediat, Pediat Intens Care Unit, Sao Paulo, Brazil-
hcfmusp.author.externalLEITE, Heitor Pons:Univ Fed Sao Paulo, Pediat Intens Care Unit, Sao Paulo, Brazil; Univ Fed Sao Paulo, Discipline Nutr & Metab, Dept Pediat, Sao Paulo, Brazil-
hcfmusp.author.externalNOGUEIRA, Paulo Cesar Koch:Univ Fed Sao Paulo, Dept Pediat, Pediat Nephrol Sect, Sao Paulo, Brazil-
hcfmusp.description.beginpage810-
hcfmusp.description.endpage815-
hcfmusp.description.issue5-
hcfmusp.description.volume28-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84883556858-
hcfmusp.origem.idWOS:000324374700038-
hcfmusp.publisher.cityPHILADELPHIA-
hcfmusp.publisher.countryUSA-
hcfmusp.relation.referenceALEGRE M, 1990, INTENS CARE MED, V16, P463, DOI 10.1007/BF01711228-
hcfmusp.relation.referenceAriyan CB, 2004, CRIT CARE MED, V32, pS146, DOI 10.1097/01.CCM.0000117172.51403.AF-
hcfmusp.relation.referenceBaines PB, 2000, ARCH DIS CHILD, V83, P510, DOI 10.1136/adc.83.6.510-
hcfmusp.relation.referenceBoink A B, 1992, J Int Fed Clin Chem, V4, P147-
hcfmusp.relation.referenceBRONER CW, 1990, CRIT CARE MED, V18, P921, DOI 10.1097/00003246-199009000-00004-
hcfmusp.relation.referenceBucley MS, 2010, CRIT CARE MED, V38, P253-
hcfmusp.relation.referenceBushinsky DA, 1998, LANCET, V352, P306, DOI 10.1016/S0140-6736(97)12331-5-
hcfmusp.relation.referenceByrnes MC, 2005, AM J SURG, V189, P310, DOI 10.1016/j.amjsurg.2004.11.017-
hcfmusp.relation.referenceCooper MS, 2008, BRIT MED J, V336, P1298, DOI 10.1136/bmj.39582.589433.BE-
hcfmusp.relation.referenceDESAI TK, 1988, AM J MED, V84, P209, DOI 10.1016/0002-9343(88)90415-9-
hcfmusp.relation.referenceDickerson RN, 2007, NUTRITION, V23, P358, DOI 10.1016/j.nut.2007.01.011-
hcfmusp.relation.referenceEgi M, 2011, CRIT CARE MED, V39, P314, DOI 10.1097/CCM.0b013e3181ffe23e-
hcfmusp.relation.referenceFrench S, 2012, SOUTH MED J, V105, P231, DOI 10.1097/SMJ.0b013e31824e1737-
hcfmusp.relation.referenceGoldstein B, 2005, PEDIATR CRIT CARE ME, V6, P1-
hcfmusp.relation.referenceGuerra LC, 2006, EPILEPSIA, V47, P1990-
hcfmusp.relation.referenceHastbacka J, 2003, ACTA ANAESTH SCAND, V47, P1264, DOI 10.1046/j.1399-6576.2003.00236.x-
hcfmusp.relation.referenceKelly A, 2011, J INTENSIVE CARE MED, DOI 10.1177/0885066611411543.[-
hcfmusp.relation.referenceKHILNANI P, 1992, CRIT CARE MED, V20, P241, DOI 10.1097/00003246-199202000-00013-
hcfmusp.relation.referenceLafrance JP, 2005, CRIT CARE CLIN, V21, P305, DOI 10.1016/j.ccc.2004.12.006-
hcfmusp.relation.referenceLee P, 2009, INTENS CARE MED, V35, P2028, DOI 10.1007/s00134-009-1642-x-
hcfmusp.relation.referenceLeteurtre S, 2003, LANCET, V362, P192, DOI 10.1016/S0140-6736(03)13908-6-
hcfmusp.relation.referenceLiamis G, 2009, J BONE MINER METAB, V27, P635, DOI 10.1007/s00774-009-0119-x-
hcfmusp.relation.referenceLyman D, 2005, AM FAM PHYSICIAN, V71, P299-
hcfmusp.relation.referenceMuller B, 2000, EUR J CLIN INVEST, V30, P823-
hcfmusp.relation.referenceRivero NC, 1989, J PEDIATR, V114, P946-
hcfmusp.relation.referenceSinghi SC, 2003, J TROP PEDIATRICS, V49, P298, DOI 10.1093/tropej/49.5.298-
hcfmusp.relation.referenceSlater A, 2003, INTENS CARE MED, V29, P278, DOI 10.1007/s00134-002-1601-2-
hcfmusp.relation.referenceSociety of Critical Care Medicine, 1991, CRIT CARE MED, V19, P275-
hcfmusp.relation.referenceTAYLOR B, 1978, CAN J SURG, V21, P429-
hcfmusp.relation.referenceWorld Health Organization, CHILD GROWTH STAND-
hcfmusp.relation.referenceZALOGA GP, 1987, ANN INTERN MED, V107, P36-
hcfmusp.relation.referenceZALOGA GP, 1986, JAMA-J AM MED ASSOC, V256, P1924, DOI 10.1001/jama.256.14.1924-
hcfmusp.relation.referenceZaloga GP, 2000, CRIT CARE MED, V28, P266, DOI 10.1097/00003246-200001000-00054-
hcfmusp.relation.referenceZivin JR, 2001, AM J KIDNEY DIS, V37, P689-
dc.description.indexMEDLINE-
hcfmusp.citation.scopus19-
hcfmusp.scopus.lastupdate2023-01-27-
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