Please use this identifier to cite or link to this item:
Title: BMP-7, MMP-9, and TGF-beta tissue remodeling proteins and their correlations with interleukins 6 and 10 in chronic rhinosinusitis
Authors: LUCAS, Bernardo RelvasVOEGELS, Richard LuisAMARAL, Jonatas Bussador doBACHI, Andre Luis LacerdaPEZATO, Rogerio
Citation: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, v.278, n.11, p.4335-4343, 2021
Abstract: Introduction Chronic rhinosinusitis without nasal polyposis (CRSsNP) and Chronic rhinosinusitis with nasal polyposis (CRSwNP) present distinct tissue remodeling processes. The proteins involved in the process of tissue remodeling have their production and activity related to the inflammatory environment they are. This study aimed to evaluate the protein expression of BMP-7, MMP-9, TGF-beta in chronic sinusitis with and without nasal polyposis and their relations with IL-6 and IL-10. Methods Cross-sectional observational study with 86 participants was divided into three groups: patients with CRSwNP (n = 34), patients with CRSsNP (n = 26), and a control group (CG) without inflammatory disease of the nasal mucosa (n = 26). The primary outcomes were the concentrations of BMP-7, MMP-9, TGF-beta, IL-6, and IL-10. Secondary outcomes were the correlations of these markers. Results The TGF-beta dosage was elevated in the CRSsNP group and reduced in the CSwNP group. The dosage of IL-6 was higher in the CSwNP group, and the IL-10 dosage lower in the groups with sinusitis, and IL-10 was positively correlated with BMP-7 in all groups. There was a negative correlation between IL-6 and IL-10 in all groups observed. The correlation between MMP-9 and interleukins was lost in the CRSsNP group. There was a positive correlation between TGF-beta and IL-6 in the CG, and negative in the CRSsNP group. Conclusion An inflammation shown in rhinosinusitis with an increase in IL-6 and decrease in IL-10 when compared with the control group; only TGF-beta was altered in the tissue remodeling process when compared with BMP-7 and MMP-9 in rhinosinusitis. There is a loss of correlation between tissue remodeling proteins and interleukins studied in CRSsNP.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MOF
Departamento de Otorrinolaringologia e Oftalmologia - FM/MOF

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/32
LIM/32 - Laboratório de Otorrinolaringologia

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion (English)1.11 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.