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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorANDRADE, Diocesio Alves Pinto de-
dc.contributor.authorSILVA, Luciane Sussuchi da-
dc.contributor.authorLAUS, Ana Carolina-
dc.contributor.authorLIMA, Marcos Alves de-
dc.contributor.authorBERARDINELLI, Gustavo Noriz-
dc.contributor.authorSILVA, Vinicius Duval da-
dc.contributor.authorMATSUSHITA, Graziela de Macedo-
dc.contributor.authorBONATELLI, Murilo-
dc.contributor.authorSILVA, Aline Larissa Virginio da-
dc.contributor.authorEVANGELISTA, Adriane Feijo-
dc.contributor.authorCARVALHO, Jesus Paula-
dc.contributor.authorREIS, Rui Manuel-
dc.contributor.authorREIS, Ricardo dos-
dc.date.accessioned2021-10-20T14:00:59Z-
dc.date.available2021-10-20T14:00:59Z-
dc.date.issued2021-
dc.identifier.citationFRONTIERS IN ONCOLOGY, v.11, 2021-
dc.identifier.issn2234-943X-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/42296-
dc.description.abstractBackground The molecular profile of endometrial cancer has become an important tool in determining patient prognosis and their optimal adjuvant treatment. In addition to The Cancer Genome Atlas (TCGA), simpler tools have been developed, such as the Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE). We attempted to determine a genetic signature to build a recurrence risk score in patients diagnosed with low- and intermediate-risk endometrial cancer. Methods A case-control study was conducted. The eligible patients were women diagnosed with recurrence low- and intermediate-risk endometrial cancer between January 2009 and December 2014 at a single institution; the recurrence patients were matched to two nonrecurrence patients with the same diagnosis by age and surgical staging. Following RNA isolation of 51 cases, 17 recurrence and 34 nonrecurrence patients, the expression profile was determined using the nCounter(R) PanCancer Pathways Panel, which contains 770 genes. Results The expression profile was successfully characterized in 49/51 (96.1%) cases. We identified 12 genes differentially expressed between the recurrence and nonrecurrence groups. The ROC curve for each gene was generated, and all had AUCs higher than 0.7. After backward stepwise logistic regression, four genes were highlighted: FN1, DUSP4, LEF1, and SMAD9. The recurrence risk score was calculated, leading to a ROC curve of the 4-gene model with an AUC of 0.93, sensitivity of 100%, and specificity of 72.7%. Conclusion We identified a four-gene signature that may be associated with recurrence in patients with low- and intermediate-risk endometrial cancer. This finding suggests a new prognostic factor in this poorly explored group of patients with endometrial cancer.eng
dc.description.sponsorshipBarretos Cancer Hospital-
dc.description.sponsorshipPublic Ministry of Labor Campinas (Research, Prevention, and Education of Occupational Cancer Project), Campinas, Brazil-
dc.description.sponsorshipCNPq productivity fellowshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)-
dc.language.isoeng-
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Oncology-
dc.rightsopenAccesseng
dc.subjectlow- and intermediate-risk endometrioid endometrial carcinomaeng
dc.subjectgenetic signatureeng
dc.subjectrecurrence risk scoreeng
dc.subjectbiomarkerseng
dc.subjectBrazileng
dc.subject.otherclinical consequenceseng
dc.subject.otherclassificationeng
dc.subject.othermutationeng
dc.subject.otherrnaeng
dc.titleA 4-Gene Signature Associated With Recurrence in Low- and Intermediate-Risk Endometrial Cancereng
dc.typearticleeng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.identifier.doi10.3389/fonc.2021.729219-
dc.identifier.pmid34485158-
dc.subject.wosOncologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalANDRADE, Diocesio Alves Pinto de:Oncol Inst Ribeirao Preto, InORP ONCOCLIN Grp, Ribeirao Preto, Brazil; Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil-
hcfmusp.author.externalSILVA, Luciane Sussuchi da:Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil-
hcfmusp.author.externalLAUS, Ana Carolina:Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil-
hcfmusp.author.externalLIMA, Marcos Alves de:Barretos Canc Hosp, Epidemiol & Biostat Nucleus, Barretos, Brazil-
hcfmusp.author.externalBERARDINELLI, Gustavo Noriz:Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil-
hcfmusp.author.externalSILVA, Vinicius Duval da:Barretos Canc Hosp, Dept Pathol, Barretos, Brazil-
hcfmusp.author.externalMATSUSHITA, Graziela de Macedo:Barretos Canc Hosp, Dept Pathol, Barretos, Brazil-
hcfmusp.author.externalBONATELLI, Murilo:Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil-
hcfmusp.author.externalSILVA, Aline Larissa Virginio da:Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil-
hcfmusp.author.externalEVANGELISTA, Adriane Feijo:Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil-
hcfmusp.author.externalREIS, Rui Manuel:Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil; Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Braga, Portugal; ICVS 3Bs PT Govt Associate Lab, Braga, Portugal-
hcfmusp.author.externalREIS, Ricardo dos:Barretos Canc Hosp, Dept Gynecol Oncol, Barretos, Brazil-
hcfmusp.description.volume11-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000695914100001-
hcfmusp.origem.id2-s2.0-85114221202-
hcfmusp.publisher.cityLAUSANNEeng
hcfmusp.publisher.countrySWITZERLANDeng
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dc.description.indexPubMedeng
hcfmusp.citation.scopus1-
hcfmusp.scopus.lastupdate2022-06-24-
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Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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