Please use this identifier to cite or link to this item:
Title: Cathechol-O-methyltransferase Val(158)Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHD
Authors: SALATINO-OLIVEIRA, AngelicaGENRO, Julia P.GUIMARAES, Ana P.CHAZAN, RodrigoZENI, CristianSCHMITZ, MarceloPOLANCZYK, GuilhermeROMAN, TatianaROHDE, Luis A.HUTZ, Mara H.
Citation: JOURNAL OF NEURAL TRANSMISSION, v.119, n.6, p.729-733, 2012
Abstract: COMT Val(158)Met polymorphism has been associated with both symptoms of attention-deficit/hyperactivity disorder (ADHD) and disruptive behavior disorders (DBD): that is, oppositional defiant disorder (ODD) and conduct disorder (CD) often comorbid with ADHD. The aim of this study was to test the association between COMT Val(158)Met polymorphism and the presence of DBD in children with ADHD (n = 516). Homozygous Val/Val children showed a higher prevalence of ADHD comorbid with DBD (chi (2) = 5.762; p = 0.016; OR = 1.58; CI95% = 1.07-2.35). Our findings replicate previous results and suggest a role for COMT in the etiology of DBD in children and adolescents with ADHD.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MPS
Departamento de Psiquiatria - FM/MPS

Artigos e Materiais de Revistas Científicas - HC/IPq
Instituto de Psiquiatria - HC/IPq

Artigos e Materiais de Revistas Científicas - LIM/21
LIM/21 - Laboratório de Neuroimagem em Psiquiatria

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion (English)178.54 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.