Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/4245| Title: | Cathechol-O-methyltransferase Val(158)Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHD |
| Authors: | SALATINO-OLIVEIRA, Angelica; GENRO, Julia P.; GUIMARAES, Ana P.; CHAZAN, Rodrigo; ZENI, Cristian; SCHMITZ, Marcelo; POLANCZYK, Guilherme; ROMAN, Tatiana; ROHDE, Luis A.; HUTZ, Mara H. |
| Citation: | JOURNAL OF NEURAL TRANSMISSION, v.119, n.6, p.729-733, 2012 |
| Abstract: | COMT Val(158)Met polymorphism has been associated with both symptoms of attention-deficit/hyperactivity disorder (ADHD) and disruptive behavior disorders (DBD): that is, oppositional defiant disorder (ODD) and conduct disorder (CD) often comorbid with ADHD. The aim of this study was to test the association between COMT Val(158)Met polymorphism and the presence of DBD in children with ADHD (n = 516). Homozygous Val/Val children showed a higher prevalence of ADHD comorbid with DBD (chi (2) = 5.762; p = 0.016; OR = 1.58; CI95% = 1.07-2.35). Our findings replicate previous results and suggest a role for COMT in the etiology of DBD in children and adolescents with ADHD. |
| Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPS Artigos e Materiais de Revistas Científicas - HC/IPq Artigos e Materiais de Revistas Científicas - LIM/21 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| art_POLANCZYK_Cathechol_O_methyltransferase_Val(158)Met_polymorphism_is_associated_with_2012.PDF Restricted Access | publishedVersion (English) | 178.54 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.