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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorSILVA, Pedro L.-
dc.contributor.authorMORAES, Lillian-
dc.contributor.authorSANTOS, Raquel S.-
dc.contributor.authorSAMARY, Cynthia-
dc.contributor.authorRAMOS, Maira B. A.-
dc.contributor.authorSANTOS, Cintia L.-
dc.contributor.authorMORALES, Marcelo M.-
dc.contributor.authorCAPELOZZI, Vera L.-
dc.contributor.authorGARCIA, Cristiane S. N. B.-
dc.contributor.authorABREU, Marcelo Gama de-
dc.contributor.authorPELOSI, Paolo-
dc.contributor.authorMARINI, John J.-
dc.contributor.authorROCCO, Patricia R. M.-
dc.date.accessioned2014-01-28T22:27:05Z-
dc.date.available2014-01-28T22:27:05Z-
dc.date.issued2013-
dc.identifier.citationCRITICAL CARE MEDICINE, v.41, n.10, p.E256-E265, 2013-
dc.identifier.issn0090-3493-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/4255-
dc.description.abstractObjective: To investigate the effects of the rate of increase in airway pressure and duration of lung recruitment maneuvers in experimental pulmonary and extrapulmonary acute lung injury. Design: Prospective, randomized, controlled experimental study. Settings: University research laboratory. Subjects: Fifty adult male Wistar rats. Interventions: Acute lung injury was induced by Escherichia coli lipopolysaccharide either intratracheally (pulmonary acute lung injury) or intraperitoneally (extrapulmonary acute lung injury). After 24 hours, animals were assigned to one of three different recruitment maneuvers, targeted to maximal airway pressure of 30cm H2O: 1) continuous positive airway pressure for 30 seconds (CPAP-30); 2) stepwise airway pressure increase (5cm H2O/step, 8.5 s at each step) over 51 seconds (STEP-51) to achieve a pressure-time product similar to that of CPAP-30; and 3) stepwise airway pressure increase (5cm H2O/step, 5 s at each step) over 30 seconds with maximum pressure sustained for a further 30 seconds (STEP-30/30). Measurements and Main Results: All recruitment maneuvers reduced static lung elastance independent of acute lung injury etiology. In pulmonary acute lung injury, CPAP-30 yielded lower surfactant protein-B and higher type III procollagen expressions compared with STEP-30/30. In extrapulmonary acute lung injury, CPAP-30 and STEP-30/30 increased vascular cell adhesion molecule-1 expression, but the type of recruitment maneuver did not influence messenger ribonucleic acid expression of receptor for advanced glycation end products, surfactant protein-B, type III procollagen, and pro-caspase 3. Conclusions: CPAP-30 worsened markers of potential epithelial cell damage in pulmonary acute lung injury, whereas both CPAP-30 and STEP-30/30 yielded endothelial injury in extrapulmonary acute lung injury. In both acute lung injury groups, recruitment maneuvers improved respiratory mechanics, but stepwise recruitment maneuver without sustained airway pressure appeared to associate with less biological impact on lungs.-
dc.description.sponsorshipCenters of Excellence Program (PRONEX-CNPq/FAPERJ)-
dc.description.sponsorshipBrazilian Council for Scientific and Technological Development (CNPq)-
dc.description.sponsorshipRio de Janeiro State Research Supporting Foundation (FAPERJ)-
dc.description.sponsorshipSao Paulo State Research Supporting Foundation (FAPESP)-
dc.description.sponsorshipNational Institute of Science and Technology of Drugs and Medicine (INCT-INOFAR)-
dc.description.sponsorshipCoordination for the Improvement of Higher Level Personnel (CAPES)-
dc.description.sponsorshipDrager Medical AG-
dc.description.sponsorshipNovalung GmbH-
dc.language.isoeng-
dc.publisherLIPPINCOTT WILLIAMS & WILKINS-
dc.relation.ispartofCritical Care Medicine-
dc.rightsrestrictedAccess-
dc.subjectalveolar collapse-
dc.subjectendothelium cells-
dc.subjectmorphometry-
dc.subjectrecruitment maneuvers-
dc.subjectrespiratory epithelium-
dc.subjectrespiratory mechanics-
dc.subject.otherrespiratory-distress-syndrome-
dc.subject.otherend-expiratory pressure-
dc.subject.othermechanical ventilation-
dc.subject.otherleukocyte kinetics-
dc.subject.otheradhesion molecules-
dc.subject.otherpulmonary-
dc.subject.otheredema-
dc.subject.otherinflation-
dc.subject.otherproducts-
dc.subject.otherreceptor-
dc.titleRecruitment Maneuvers Modulate Epithelial and Endothelial Cell Response According to Acute Lung Injury Etiology-
dc.typearticle-
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS-
dc.identifier.doi10.1097/CCM.0b013e31828a3c13-
dc.identifier.pmid23887231-
dc.subject.wosCritical Care Medicine-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalSILVA, Pedro L.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalMORAES, Lillian:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalSANTOS, Raquel S.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalSAMARY, Cynthia:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalRAMOS, Maira B. A.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalSANTOS, Cintia L.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, BR-21941902 Rio De Janeiro, RJ, Brazil; Univ Fed Rio de Janeiro, Fac Med, Lab Expt Surg, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalMORALES, Marcelo M.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Cellular & Mol Physiol, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.author.externalGARCIA, Cristiane S. N. B.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, BR-21941902 Rio De Janeiro, RJ, Brazil; Rio de Janeiro Fed Inst Educ Sci & Technol, Rio De Janeiro, Brazil-
hcfmusp.author.externalABREU, Marcelo Gama de:Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Anesthesiol & Intens Care Therapy, Pulm Engn Grp, Dresden, Germany-
hcfmusp.author.externalPELOSI, Paolo:Univ Genoa, IRCCS AOU San Martino IST, Dept Surg Sci & Integrated Diagnost, Genoa, Italy-
hcfmusp.author.externalMARINI, John J.:Univ Minnesota, Minnesota Reg Hosp, Minneapolis, MN USA-
hcfmusp.author.externalROCCO, Patricia R. M.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, BR-21941902 Rio De Janeiro, RJ, Brazil-
hcfmusp.description.beginpageE256-
hcfmusp.description.endpageE265-
hcfmusp.description.issue10-
hcfmusp.description.volume41-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84884877375-
hcfmusp.origem.idWOS:000324935000002-
hcfmusp.publisher.cityPHILADELPHIA-
hcfmusp.publisher.countryUSA-
hcfmusp.relation.referenceBAYDUR A, 1982, AM REV RESPIR DIS, V126, P788-
hcfmusp.relation.referenceCalfee CS, 2008, THORAX, V63, P1083, DOI 10.1136/thx.2008.095588-
hcfmusp.relation.referenceChesnutt AN, 1997, AM J RESP CRIT CARE, V156, P840-
hcfmusp.relation.referenceConstantin JM, 2007, ANESTHESIOLOGY, V106, P944, DOI 10.1097/01.anes.0000265153.17062.64-
hcfmusp.relation.referenceCRUZORIVE LM, 1990, AM J PHYSIOL, V258, pL148-
hcfmusp.relation.referenceD'Angelo E, 2004, J APPL PHYSIOL, V97, P260, DOI 10.1152/japplphysiol.01175.2003-
hcfmusp.relation.referencede Prost N, 2007, J APPL PHYSIOL, V102, P794, DOI 10.1152/japplphysiol.00742.2006-
hcfmusp.relation.referenceDessap AM, 2012, AM J RESP CELL MOL, V46, P541, DOI 10.1165/rcmb.2011-0306OC-
hcfmusp.relation.referenceFan E, 2008, AM J RESP CRIT CARE, V178, P1156, DOI 10.1164/rccm.200802-335OC-
hcfmusp.relation.referenceGattinoni L, 2012, CURR OPIN ANESTHESIO, V25, P141, DOI 10.1097/ACO.0b013e3283503125-
hcfmusp.relation.referenceHodgson Carol L, 2011, J Intensive Care Med, V26, P41, DOI 10.1177/0885066610383953-
hcfmusp.relation.referenceLaffey JG, 2004, INTENS CARE MED, V30, P347, DOI 10.1007/s00134-003-2051-1-
hcfmusp.relation.referenceLeite JHP, 2008, CRIT CARE MED, V36, P2621, DOI 10.1097/CCM.0b013e3181847b43-
hcfmusp.relation.referenceLowhagen K, 2011, ACTA ANAESTH SCAND, V55, P175, DOI 10.1111/j.1399-6576.2010.02366.x-
hcfmusp.relation.referenceMatute-Bello G, 2011, AM J RESP CELL MOL, V44, P725, DOI 10.1165/rcmb.2009-0210ST-
hcfmusp.relation.referenceMiserocchi G, 2001, NEWS PHYSIOL SCI, V16, P66-
hcfmusp.relation.referenceMiyao N, 2006, AM J PHYSIOL-LUNG C, V290, pL1059, DOI 10.1152/ajplung.00365.2005-
hcfmusp.relation.referenceMoran I, 2011, MINERVA ANESTESIOL, V77, P1167-
hcfmusp.relation.referenceNag K, 1999, AM J PHYSIOL-LUNG C, V277, pL1179-
hcfmusp.relation.referenceNishio K, 1998, AM J RESP CRIT CARE, V157, P599-
hcfmusp.relation.referenceNucci G, 2003, J APPL PHYSIOL, V95, P348, DOI 10.1152/japplphysiol.01179.2001-
hcfmusp.relation.referencePalestini P, 2003, J APPL PHYSIOL, V95, P1446, DOI 10.1152/japplphysiol.00208.2003-
hcfmusp.relation.referencePassaro CP, 2009, CRIT CARE MED, V37, P1011, DOI 10.1097/CCM.0b013e3181962d85-
hcfmusp.relation.referencePerl M, 2011, EXPERT REV RESP MED, V5, P115, DOI [10.1586/ers.10.92, 10.1586/ERS.10.92]-
hcfmusp.relation.referencePerlman CE, 2007, J APPL PHYSIOL, V103, P1037, DOI 10.1152/japplphysiol.00160.2007-
hcfmusp.relation.referenceRAGHU G, 1985, AM REV RESPIR DIS, V131, P281-
hcfmusp.relation.referenceRiva DR, 2008, CRIT CARE MED, V36, P1900, DOI 10.1097/CCM.0b013e3181760e5d-
hcfmusp.relation.referenceRoan E, 2011, AM J PHYSIOL-LUNG C, V301, pL625, DOI 10.1152/ajplung.00105.2011-
hcfmusp.relation.referenceSantiago VR, 2010, CRIT CARE MED, V38, P2207, DOI 10.1097/CCM.0b013e3181f3e076-
hcfmusp.relation.referenceSavla U, 2002, J PHYSIOL-LONDON, V539, P285, DOI 10.1013/jphysiol.2001.012945-
hcfmusp.relation.referenceSilva PL, 2010, CRIT CARE, V14, DOI 10.1186/cc9063-
hcfmusp.relation.referenceSilva PL, 2011, CRIT CARE MED, V39, P1074, DOI 10.1097/CCM.0b013e318206d69a-
hcfmusp.relation.referenceSlee EA, 1999, J CELL BIOL, V144, P281, DOI 10.1083/jcb.144.2.281-
hcfmusp.relation.referenceSpieth PM, 2012, CRIT CARE, V16, DOI 10.1186/cc11177-
hcfmusp.relation.referenceUchida T, 2006, AM J RESP CRIT CARE, V173, P1008, DOI 10.1164/rccm.200509-1477OC-
dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipCAPES-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFAPERJ-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.remissive.sponsorshipINCTs-
hcfmusp.remissive.sponsorshipCAPES-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFAPERJ-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.remissive.sponsorshipINCTs-
hcfmusp.citation.scopus44-
hcfmusp.scopus.lastupdate2022-06-24-
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