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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | QUARESMA, Juarez A. S. | - |
dc.contributor.author | PAGLIARI, Carla | - |
dc.contributor.author | MEDEIROS, Daniele B. A. | - |
dc.contributor.author | DUARTE, Maria I. S. | - |
dc.contributor.author | VASCONCELOS, Pedro F. C. | - |
dc.date.accessioned | 2014-01-28T22:27:07Z | - |
dc.date.available | 2014-01-28T22:27:07Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | REVIEWS IN MEDICAL VIROLOGY, v.23, n.5, p.305-318, 2013 | - |
dc.identifier.issn | 1052-9276 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/4267 | - |
dc.description.abstract | Yellow fever is a viral hemorrhagic fever, which affects people living in Africa and South America and is caused by the yellow fever virus, the prototype species in the Flavivirus genus (Flaviviridae family). Yellow fever virus infection can produce a wide spectrum of symptoms, ranging from asymptomatic infection or oligosymptomatic illness to severe disease with a high fatality rate. In this review, we focus in the mechanisms associated with the physiopathology of yellow fever in humans and animal models. It has been demonstrated that several factors play a role in the pathological outcome of the severe form of the disease including direct viral cytopathic effect, necrosis and apoptosis of hepatocyte cells in the midzone, and a minimal inflammatory response as well as low-flow hypoxia and cytokine overproduction. New information has filled several gaps in the understanding of yellow fever pathogenesis and helped comprehend the course of illness. Finally, we discuss prospects for an immune therapy in the light of new immunologic, viral, and pathologic tools. | - |
dc.description.sponsorship | National Institute for Science and Technology for Viral Hemorrhagic Fevers by National Council for Scientific and Technological Development | - |
dc.description.sponsorship | Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) | - |
dc.description.sponsorship | CNPq [301641/2010-2] | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado do Para (FAPESPA) [573739/2008-0] | - |
dc.language.iso | eng | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.ispartof | Reviews in Medical Virology | - |
dc.rights | restrictedAccess | - |
dc.subject.other | chronic hepatitis-c | - |
dc.subject.other | hamster mesocricetus-auratus | - |
dc.subject.other | dengue hemorrhagic-fever | - |
dc.subject.other | human-liver | - |
dc.subject.other | virus-infection | - |
dc.subject.other | endothelial-cells | - |
dc.subject.other | apoptosis | - |
dc.subject.other | mechanisms | - |
dc.subject.other | injury | - |
dc.subject.other | necrosis | - |
dc.title | Immunity and immune response, pathology and pathologic changes: progress and challenges in the immunopathology of yellow fever | - |
dc.type | article | - |
dc.rights.holder | Copyright WILEY-BLACKWELL | - |
dc.identifier.doi | 10.1002/rmv.1752 | - |
dc.identifier.pmid | 23873723 | - |
dc.subject.wos | Virology | - |
dc.type.category | review | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | QUARESMA, Juarez A. S.:Fed Univ Para, Nucleo Med Trop, BR-66059 Belem, Para, Brazil; Univ Estado Para, Dept Patol, Belem, Para, Brazil | - |
hcfmusp.author.external | MEDEIROS, Daniele B. A.:SVS Minist Saude, Inst Evandro Chagas, Dept Arbovirol & Febres Hemoprrag, Ananindeua, Para, Brazil | - |
hcfmusp.author.external | VASCONCELOS, Pedro F. C.:SVS Minist Saude, Inst Evandro Chagas, Dept Arbovirol & Febres Hemoprrag, Ananindeua, Para, Brazil; Univ Estado Para, Dept Patol, Belem, Para, Brazil | - |
hcfmusp.description.beginpage | 305 | - |
hcfmusp.description.endpage | 318 | - |
hcfmusp.description.issue | 5 | - |
hcfmusp.description.volume | 23 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84882617470 | - |
hcfmusp.origem.id | WOS:000323250000005 | - |
hcfmusp.publisher.city | HOBOKEN | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CAPES | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.citation.scopus | 66 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/06 Artigos e Materiais de Revistas Científicas - ODS/03 |
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