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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorNUKUMIZU, L. A.-
dc.contributor.authorSAAD, C. Goncalves-
dc.contributor.authorOSTENSEN, M.-
dc.contributor.authorALMEIDA, B. P.-
dc.contributor.authorCOCUZZA, M.-
dc.contributor.authorGONCALVES, C.-
dc.contributor.authorSAITO, O.-
dc.contributor.authorBONFA, E.-
dc.contributor.authorSILVA, C. A.-
dc.identifier.citationSCANDINAVIAN JOURNAL OF RHEUMATOLOGY, v.41, n.6, p.476-481, 2012-
dc.description.abstractObjective: To assess reproductive function in male ankylosing spondylitis (AS) patients in comparison to healthy controls. Methods: Twenty AS patients were compared to 24 healthy male subjects with regard to demographic data, urological examination, testicular ultrasound (US), semen analysis, anti-sperm antibodies, and hormone profile. Exclusion criteria were present use of sulfasalazine or methotrexate, and ever use of biological/cytotoxic agents. Disease activity of AS was evaluated by clinical and laboratory assessments. Results: Demographic data were similar in AS and controls (p = 0.175). Varicocele was found significantly more frequently in AS patients than in controls (40% vs. 8%, p = 0.027). Semen analysis revealed no significant differences in sperm quality between AS patients and controls (p > 0.05). By contrast, the median of normal sperm forms was significantly lower in AS patients with vs. those without varicocele [13.5 (range 2-27) vs. 22 (range 10-32.5)%, p = 0.049] whereas no difference in sperm morphology was observed comparing AS patients and controls without varicocele (p = 0.670). Comparison of AS patients with and without varicocele showed that anti-sperm antibodies, hormones, inflammatory markers, and disease activity scores did not contribute to the impaired sperm morphology observed in AS patients with varicocele. Conclusions: An increased frequency of varicocele was found in AS patients associated with sperm abnormalities but independent of therapy, anti-sperm antibodies, hormonal alterations, or disease parameters. Investigation for varicocele should be routine in AS patients with fertility problems.-
dc.description.sponsorshipFoundation for Research Support of the State of Sao Paulo (FAPESP) [2009/51897-5]-
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPQ) [301411/2009-3, 302724/2011-7]-
dc.description.sponsorshipFederico Foundation Grants-
dc.relation.ispartofScandinavian Journal of Rheumatology-
dc.subject.otherjuvenile dermatomyositis-
dc.subject.otherimmunosuppressive drugs-
dc.titleGonadal function in male patients with ankylosing spondylitis-
dc.rights.holderCopyright INFORMA HEALTHCARE-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, M.:Univ Bern, Pregnancy Res Unit, Dept Rheumatol, CH-3012 Bern, Switzerland-
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hcfmusp.remissive.sponsorshipFederico Foundation-
hcfmusp.remissive.sponsorshipFederico Foundation-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/ICr
Instituto da Criança - HC/ICr

Artigos e Materiais de Revistas Científicas - HC/InRad
Instituto de Radiologia - HC/InRad

Artigos e Materiais de Revistas Científicas - LIM/17
LIM/17 - Laboratório de Investigação em Reumatologia

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica

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