Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/43806
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorGOMES, Joao Lucas Penteado-
dc.contributor.authorTOBIAS, Gabriel Cardial-
dc.contributor.authorFERNANDES, Tiago-
dc.contributor.authorSILVEIRA, Andre Casanova-
dc.contributor.authorNEGRAO, Carlos Eduardo-
dc.contributor.authorCHAMMAS, Roger-
dc.contributor.authorBRUM, Patricia Chakur-
dc.contributor.authorOLIVEIRA, Edilamar Menezes-
dc.date.accessioned2021-12-16T14:18:43Z-
dc.date.available2021-12-16T14:18:43Z-
dc.date.issued2021-
dc.identifier.citationCANCERS, v.13, n.22, article ID 5728, 19p, 2021-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/43806-
dc.description.abstractSimple SummaryMuscle wasting is a symptom of the cancer cachexia closely related to the imbalance between protein synthesis and degradation. MyomiRs are small RNA molecules that do not encode proteins and have the function of regulating protein-coding genes, and in this way, myomiRs can regulate the homeostasis of skeletal muscle cells submitted to physiological or pathological stimulus. Aerobic exercise training (AET) is a nonpharmacological adjuvant treatment to prevent cancer cachexia, improving the patient's quality of life. MyomiRs are modulated by cancer and AET, as well. Thus, we propose to investigate the effects promoted by AET on circulating and skeletal muscle myomiRs in cachectic and non-cachectic cancer mice. Exercise is a promising therapy for cancer-associated muscle wasting, revealing the importance to understand the molecular mechanisms involved to preserve muscle mass.We investigated the effects of AET on myomiRs expression in the skeletal muscle and serum of colon cachectic (CT26) and breast non-cachectic (MMTV-PyMT) cancer mice models. Colon cancer decreased microRNA-486 expression, increasing PTEN in tibialis anterior muscle (TA), decreasing the PI3K/mTOR protein pathway, body and muscle wasting, fibers' cross-sectional area and muscle dysfunction, that were not preserved by AET. In contrast, breast cancer decreased those muscle functions, but were preserved by AET. In circulation, the downregulation of microRNA-486 and -206 in colon cancer, and the downregulation of microRNA-486 and upregulation of microRNA-206 expression in breast cancer might be good cancer serum biomarkers. Since the microRNA-206 is skeletal muscle specific, their expression was increased in the TA, serum and tumor in MMTV, suggesting a communication among these three compartments. The AET prevents these effects on microRNA-206, but not on microRNA-486 in MMTV. In conclusion, cancer induced a downregulation of microRNA-486 expression in TA and serum of CT26 and MMTV mice and these effects were not prevented by AET; however, to MMTV, the trained muscle function was preserved, probably sustained by the downregulation of microRNA-206 expression. Serum microRNA-206 is a potential biomarker for colon (decreased) and breast (increased) cancer to monitor the disease evolution and the effects promoted by the AET.eng
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/22814-5, 2015/04788-7]-
dc.description.sponsorshipUniversity of Sao Paulo/Provost Office for Research- MicroRNA Research Nucleus (USP/PRP-NAPmiR)-
dc.description.sponsorshipNational Council for Scientific and Technological Development-CNPQConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [313479/2017-8, 306261/2016-2, 303573/2015-5]-
dc.description.sponsorshipCoordination of Superior Level Staff Improvement-Academic Excellence Program (CAPES-PROEX)-
dc.language.isoeng-
dc.publisherMDPIeng
dc.relation.ispartofCancers-
dc.rightsopenAccesseng
dc.subjectmyomiRseng
dc.subjectcolon cancereng
dc.subjectbreast cancereng
dc.subjectmuscle wastingeng
dc.subjectcancer cachexiaeng
dc.subjectCT26 cancer modeleng
dc.subjectMMTV-PyMT miceeng
dc.subjectaerobic exercise trainingeng
dc.subject.othermuscle-specific micrornaseng
dc.subject.otherskeletal-muscleeng
dc.subject.othercell-proliferationeng
dc.subject.otherbreast-cancereng
dc.subject.otherup-regulationeng
dc.subject.othermir-206eng
dc.subject.othermodulationeng
dc.subject.otherbiomarkerseng
dc.subject.otherreleaseeng
dc.subject.othergrowtheng
dc.titleEffects of Aerobic Exercise Training on MyomiRs Expression in Cachectic and Non-Cachectic Cancer Miceeng
dc.typearticleeng
dc.rights.holderCopyright MDPIeng
dc.identifier.doi10.3390/cancers13225728-
dc.identifier.pmid34830882-
dc.subject.wosOncologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalGOMES, Joao Lucas Penteado:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil-
hcfmusp.author.externalTOBIAS, Gabriel Cardial:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil-
hcfmusp.author.externalFERNANDES, Tiago:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil-
hcfmusp.author.externalSILVEIRA, Andre Casanova:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil-
hcfmusp.author.externalBRUM, Patricia Chakur:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil-
hcfmusp.author.externalOLIVEIRA, Edilamar Menezes:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil-
hcfmusp.description.articlenumber5728-
hcfmusp.description.issue22-
hcfmusp.description.volume13-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000723757500001-
hcfmusp.origem.id2-s2.0-85118989350-
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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dc.description.indexPubMedeng
dc.identifier.eissn2072-6694-
hcfmusp.citation.scopus0-
hcfmusp.scopus.lastupdate2022-06-09-
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