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Title: Improvement of Non-motor Symptoms and Quality of Life After Deep Brain Stimulation for Refractory Dystonia: A 1-Year Follow-Up
Authors: LISTIK, ClariceCURY, Rubens GisbertCASAGRANDE, Sara Carvalho BarbosaLISTIK, EduardoARNAUT, DeboraSANTIAGO, NatallySILVA, Valquiria Aparecida DaGALHARDONI, RicardoMACHADO, Julia de Lima ArantesALMEIDA, Jessica Campelo deBARBOSA, Egberto ReisTEIXEIRA, Manoel JacobsenANDRADE, Daniel Ciampi De
Citation: FRONTIERS IN NEUROLOGY, v.12, article ID 717239, 7p, 2021
Abstract: Introduction: Deep brain stimulation (DBS) is a treatment option for refractory dystonia's motor symptoms, while its non-motor symptoms (NMS) have been less systematically assessed. We aimed to describe the effects of DBS on NMS in refractory generalized inherited/idiopathic dystonia prospectively.</p> Methods: We evaluated patients before and 1 year after DBS surgery and applied the following scales: Burke-Fahn-Marsden Rating Scale (BFMRS), NMS Scale for Parkinson's Disease (NMSS-PD), Parkinson's Disease Questionnaire-8, short-form Brief Pain Inventory (BPI), Neuropathic Pain Symptom Inventory (NPSI), and short-form McGill Pain Questionnaire (MPQ).</p> Results: Eleven patients (38.35 +/- 11.30 years) underwent surgery, all with generalized dystonia. Motor BFMRS subscore was 64.36 +/- 22.94 at baseline and 33.55 +/- 17.44 1 year after DBS surgery (47.9% improvement, p = 0.003). NMSS-PD had a significant change 12 months after DBS, from 70.91 +/- 59.07 to 37.18 +/- 55.05 (47.5% improvement, p = 0.013). NMS changes were mainly driven by changes in the gastrointestinal (p = 0.041) and miscellaneous domains (p = 0.012). Seven patients reported chronic pain before DBS and four after it. BPI's severity and interference scores were 4.61 +/- 2.84 and 4.12 +/- 2.67, respectively, before surgery, and 2.79 +/- 2.31 (0.00-6.25) and 1.12 +/- 1.32 (0.00-3.00) after, reflecting a significant improvement (p = 0.043 and p = 0.028, respectively). NPSI score was 15.29 +/- 13.94 before, while it was reduced to 2.29 +/- 2.98 afterward (p = 0.028). MPQ's total score was 9.00 +/- 3.32 before DBS, achieving 2.71 +/- 2.93 after (p = 0.028).</p> Conclusions: DBS improves NMS in generalized inherited/idiopathic dystonia, including chronic pain.</p>
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Artigos e Materiais de Revistas Científicas - FM/MNE
Departamento de Neurologia - FM/MNE

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/IPq
Instituto de Psiquiatria - HC/IPq

Artigos e Materiais de Revistas Científicas - LIM/45
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica

Artigos e Materiais de Revistas Científicas - LIM/62
LIM/62 - Laboratório de Fisiopatologia Cirúrgica

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