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https://observatorio.fm.usp.br/handle/OPI/44080
Título: | Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. VIII: CAR-T cells: preclinical development - Safety and efficacy evaluation |
Autor: | PICANCO-CASTRO, Virginia; BONAMINO, Martin Hernan; RAMOS, Rodrigo Nalio; GUERINO-CUNHA, Renato L.; OLIVEIRA, Theo Gremen M.; REGO, Eduardo M. |
Citación: | HEMATOLOGY TRANSFUSION AND CELL THERAPY, v.43, suppl.2, p.S54-S63, 2021 |
Resumen: | Currently, there are four CAR-T products commercially available on the market. CAR-T cells have shown high remission rates and they represent an effective treatment option for patients with resistant or refractory B cell malignancies. Approval of these cell therapy products came after an extended period of preclinical evaluation that demonstrated unprecedented efficacy in this difficult-to-treat patient population. This review article outlines the main preclinical evaluations needed for CAR T cell product development. (C) 2021 Published by Elsevier Espana, S.L.U. on behalf of Associacao Brasileira de Hematologia, Hemoterapia e Terapia Celular. |
Aparece en las colecciones: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/31 Artigos e Materiais de Revistas Científicas - ODS/03 |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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art_PICANCO-CASTRO_Associacao_Brasileira_de_Hematologia_Hemoterapia_e_Terapia_Celular_2021.PDF | publishedVersion (English) | 880.06 kB | Adobe PDF | Visualizar/Abrir |
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