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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorPIMENTEL, Walace de Souza-
dc.contributor.authorRAMIRES, Felix Jose Alvarez-
dc.contributor.authorIANNI, Barbara Maria-
dc.contributor.authorSALEMI, Vera Maria Cury-
dc.contributor.authorBILATE, Angelina Morand Bianchi-
dc.contributor.authorCUNHA-NETO, Edecio-
dc.contributor.authorOLIVEIRA, Adriana Morgan de-
dc.contributor.authorFERNANDES, Fabio-
dc.contributor.authorMADY, Charles-
dc.identifier.citationCLINICS, v.67, n.9, p.1063-1069, 2012-
dc.description.abstractOBJECTIVE: Chagas' disease has spread throughout Latin America because of the high rate of migration among these countries. Approximately 30% of Chagas' patients will develop cardiomyopathy, and 10% of these will develop severe cardiac damage leading to heart failure. Beta-blockade improves symptoms and survival in heart failure patients; however, its efficacy has not been well established in Chagas' disease. We evaluated the role of carvedilol in cardiac remodeling and mortality in a Chagas' cardiomyopathy animal model. METHODS: We studied Trypanosoma cruzi infection in 55 Syrian hamsters that were divided into three groups: control (15), infected (20), and infected + carvedilol (20). Animals underwent echocardiography, electrocardiography, and morphometry for collagen evaluation in ventricles stained with picrosirius red. RESULTS: The left ventricular diastolic diameter did not change between groups, although it was slightly larger in infected groups, as was left ventricular systolic diameter. Fractional shortening also did not change between groups, although it was slightly lower in infected groups. Collagen accumulation in the interstitial myocardial space was significantly higher in infected groups and was not attenuated by carvedilol. The same response was observed in the perivascular space. The survival curve showed significantly better survival in the control group compared with the infected groups; but no benefit of carvedilol was observed during the study. However, in the acute phase (up to 100 days of infection), carvedilol did reduce mortality. CONCLUSION: Carvedilol did not attenuate cardiac remodeling or mortality in this model of Chagas' cardiomyopathy. The treatment did improve survival in the acute phase of the disease.-
dc.description.sponsorshipFAPESP, Brazil [12/11438-4]-
dc.subjectChagas' Cardiomyopathy-
dc.subjectMyocardial Fibrosis-
dc.subjectCardiac Dysfunction-
dc.subjectMyocardial Remodeling-
dc.subject.otherchronic heart-failure-
dc.titleThe effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy-
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULO-
dc.subject.wosMedicine, General & Internal-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Walace de Souza:HC FMUSP, Inst Coracao InCor, Unidade Clin Miocardiopatias, Sao Paulo, Brazil-, Angelina Morand Bianchi:HC FMUSP, Inst Coracao InCor, Unidade Clin Miocardiopatias, Sao Paulo, Brazil-
hcfmusp.publisher.citySAO PAULO-
hcfmusp.relation.referenceAdamson PB, 2006, J CARD FAIL, V12, P734, DOI 10.1016/j.cardfail.2006.08.213-
hcfmusp.relation.referenceAslam S, 2008, CURR OPIN NEPHROL HY, V17, P99-
hcfmusp.relation.referenceAufderheide AC, 2004, P NATL ACAD SCI USA, V101, P2034, DOI 10.1073/pnas.0307312101-
hcfmusp.relation.referenceBern C, 2007, JAMA-J AM MED ASSOC, V298, P2171, DOI 10.1001/jama.298.18.2171-
hcfmusp.relation.referenceBestetti RB, 2011, INT J CARDIOL, V151, P205, DOI 10.1016/j.ijcard.2010.05.033-
hcfmusp.relation.referenceBilate AMB, 2003, MICROBES INFECT, V5, P1116, DOI 10.1016/j.micinf.2003.07.001-
hcfmusp.relation.referenceBotoni Fernando A, 2007, Am Heart J, V153, DOI 10.1016/j.ahj.2006.12.017-
hcfmusp.relation.referenceLechat P, 1999, LANCET, V353, P9-
hcfmusp.relation.referenceDavila DF, 2008, INT J CARDIOL, V128, P1, DOI 10.1016/j.ijcard.2008.01.001-
hcfmusp.relation.referenceDavila DF, 2002, INT J CARDIOL, V85, P255, DOI 10.1016/S0167-5273(02)00181-X-
hcfmusp.relation.referenceDias Joao Carlos Pinto, 2002, Rev Soc Bras Med Trop, V35, P167, DOI 10.1590/S0037-86822002000200007-
hcfmusp.relation.referenceDourado KC, 2006, INT J CARDIOL, V108, P412, DOI 10.1016/j.ijcard.2005.03.041-
hcfmusp.relation.referenceFernandez Ruth, 1998, Acta Physiologica Pharmacologica et Therapeutica Latinoamericana, V48, P93-
hcfmusp.relation.referenceHiguchi MD, 2003, CARDIOVASC RES, V60, P96, DOI 10.1016/S0008-6363(03)00361-4-
hcfmusp.relation.referenceMarin JA, 2007, CIRCULATION, V115, P1109, DOI 10.1161/CIRCULATIONAHA.106.624296-
hcfmusp.relation.referenceHjalmarson A, 1999, LANCET, V353, P2001-
hcfmusp.relation.referenceNastari L, 2011, ARQ BRAS CARDIOL, V96, P99-
hcfmusp.relation.referencePacker M, 1996, NEW ENGL J MED, V334, P1349, DOI 10.1056/NEJM199605233342101-
hcfmusp.relation.referenceRamires FJA, 2006, J RENIN-ANGIO-ALDO S, V7, P162, DOI 10.3317/jraas.2006.026-
hcfmusp.relation.referenceRassi A, 2010, LANCET, V375, P1388, DOI 10.1016/S0140-6736(10)60061-X-
hcfmusp.relation.referenceSalemi Vera M C, 2005, Eur J Echocardiogr, V6, P41, DOI 10.1016/j.euje.2004.06.001-
hcfmusp.relation.referenceSterin-Borda L, 1999, CARDIOVASC RES, V41, P116, DOI 10.1016/S0008-6363(98)00225-9-
hcfmusp.relation.referenceTheodoropoulos TAD, 2008, INT J CARDIOL, V128, P22, DOI 10.1016/j.ijcard.2007.11.057-
hcfmusp.relation.reference[UNDP World Bank WHO], 1991, SPEC PROGR RES TRAIN, P67-
hcfmusp.relation.referenceWHO-World Health Organization, 2009, 12417 WHO EB-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/11
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação

Artigos e Materiais de Revistas Científicas - LIM/19
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular

Artigos e Materiais de Revistas Científicas - LIM/60
LIM/60 - Laboratório de Imunologia Clínica e Alergia

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