Use este identificador para citar ou linkar para este item: https://observatorio.fm.usp.br/handle/OPI/44239
Título: Polygenic risk scores across the extended psychosis spectrum
Autor(es): SMIGIELSKI, LukaszPAPIOL, SergiTHEODORIDOU, AnastasiaHEEKEREN, KarstenGERSTENBERG, MiriamWOTRUBA, DianaBUECHLER, RomanHOFFMANN, PerHERMS, StefanADORJAN, KristinaANDERSON-SCHMIDT, HeikeBUDDE, MonikaCOMES, Ashley L.GADE, KatrinHEILBRONNER, MariaHEILBRONNER, UrsKALMAN, Janos L.KLOEHN-SAGHATOLISLAM, FarahnazREICH-ERKELENZ, DanielaSCHAUPP, Sabrina K.SCHULTE, Eva C.SENNER, FannyANGHELESCU, Ion-GeorgeAROLT, VolkerBAUNE, Bernhard T.DANNLOWSKI, UdoDIETRICH, Detlef E.FALLGATTER, Andreas J.FIGGE, ChristianJAEGER, MarkusJUCKEL, GeorgKONRAD, CarstenNIERATSCHKER, VanessaREIMER, JensREININGHAUS, EvaSCHMAUSS, MaxSPITZER, CarstenHAGEN, Martin vonWILTFANG, JensZIMMERMANN, JoergGRYAZNOVA, AnnaFLATAU-NAGEL, LauraREITT, MarkusMEYERS, MilenaEMONS, BarbaraHAUSSLEITER, Ida SybilleLANG, Fabian U.BECKER, ThomasWIGAND, Moritz E.WITT, Stephanie H.DEGENHARDT, FranziskaFORSTNER, Andreas J.RIETSCHEL, MarcellaNOTHEN, Markus M.ANDLAUER, Till F. M.ROESSLER, WulfWALITZA, SusanneFALKAI, PeterSCHULZE, Thomas G.GRUENBLATT, Edna
Parte de: TRANSLATIONAL PSYCHIATRY, v.11, n.1, article ID 600, 11p, 2021
Resumo: As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In this context, polygenic risk scores (PRSs) quantifying the additive effects of multiple common genetic variants hold the potential to predict complex diseases and index severity gradients. PRSs for schizophrenia (SZ) and bipolar disorder (BD) were computed using Bayesian regression and continuous shrinkage priors based on the latest SZ and BD genome-wide association studies (Psychiatric Genomics Consortium, third release). Eight well-phenotyped groups (n = 1580; 56% males) were assessed: control (n = 305), lower (n = 117) and higher (n = 113) schizotypy (both groups of healthy individuals), at-risk for psychosis (n = 120), BD type-I (n = 359), BD type-II (n = 96), schizoaffective disorder (n = 86), and SZ groups (n = 384). PRS differences were investigated for binary traits and the quantitative Positive and Negative Syndrome Scale. Both BD-PRS and SZ-PRS significantly differentiated controls from at-risk and clinical groups (Nagelkerke's pseudo-R-2: 1.3-7.7%), except for BD type-II for SZ-PRS. Out of 28 pairwise comparisons for SZ-PRS and BD-PRS, 9 and 12, respectively, reached the Bonferroni-corrected significance. BD-PRS differed between control and at-risk groups, but not between at-risk and BD type-I groups. There was no difference between controls and schizotypy. SZ-PRSs, but not BD-PRSs, were positively associated with transdiagnostic symptomology. Overall, PRSs support the continuum model across the psychosis spectrum at the genomic level with possible irregularities for schizotypy. The at-risk state demands heightened clinical attention and research addressing symptom course specifiers. Continued efforts are needed to refine the diagnostic and prognostic accuracy of PRSs in mental healthcare.
Aparece nas coleções:

Artigos e Materiais de Revistas Científicas - LIM/27
LIM/27 - Laboratório de Neurociências


Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
art_SMIGIELSKI_Polygenic_risk_scores_across_the_extended_psychosis_spectrum_2021.PDFpublishedVersion (English)2.2 MBAdobe PDFThumbnail
Visualizar/Abrir

Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.