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https://observatorio.fm.usp.br/handle/OPI/44456
Title: | In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19* |
Authors: | TEN-CATEN, Felipe; GONZALEZ-DIAS, Patricia; CASTRO, Icaro; OGAVA, Rodrigo L. T.; GIDDALURU, Jeevan; SILVA, Juan Carlo S.; MARTINS, Felipe; GONCALVES, Andre N. A.; COSTA-MARTINS, Andre G.; ARAUJO, Jose D.; VIEGAS, Ana Carolina; CUNHA, Fernando Q.; FARSKY, Sandra; BOZZA, Fernando A.; LEVIN, Anna S.; PANNARAJ, Pia S.; I, Thushan de Silva; MINOPRIO, Paola; SILVA, Fabiano Pinheiro da; ANDRADE, Bruno B.; I, Helder Nakaya |
Citation: | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.105, p.579-587, 2021 |
Abstract: | Background: The progression and severity of COVID-19 vary significantly in the population. While the hallmarks of SARS-CoV-2 and severe COVID-19 within routine laboratory parameters are emerging, the impact of sex and age on these profiles is still unknown. Methods: A multidimensional analysis was performed involving millions of records of laboratory parameters and diagnostic tests for 178 887 individuals from Brazil, of whom 33 266 tested positive for SARS-CoV-2. Analyzed data included those relating to complete blood cell count, electrolytes, metabolites, arterial blood gases, enzymes, hormones, cancer biomarkers, and others. Findings: COVID-19 induced similar alterations in laboratory parameters in males and females. CRP and ferritin were increased, especially in older men with COVID-19, whereas abnormal liver function tests were common across several age groups, except for young women. Low peripheral blood basophils and eosinophils were more common in the elderly with COVID-19. Both male and female COVID-19 patients admitted to intensive care units displayed alterations in the coagulation system, and higher values for neutrophils, CRP, and lactate dehydrogenase. Conclusions: Our study uncovered the laboratory profiles of a large cohort of COVID-19 patients, which formed the basis of discrepancies influenced by aging and biological sex. These profiles directly linked COVID-19 disease presentation to an intricate interplay between sex, age, and immune activation. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - COVID-19 Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/46 Artigos e Materiais de Revistas Científicas - LIM/49 Artigos e Materiais de Revistas Científicas - LIM/51 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_TEN-CATEN_Indepth_analysis_of_laboratory_parameters_reveals_the_interplay_2021.PDF | publishedVersion (English) | 3.05 MB | Adobe PDF | View/Open |
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