Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/44456
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorTEN-CATEN, Felipe-
dc.contributor.authorGONZALEZ-DIAS, Patricia-
dc.contributor.authorCASTRO, Icaro-
dc.contributor.authorOGAVA, Rodrigo L. T.-
dc.contributor.authorGIDDALURU, Jeevan-
dc.contributor.authorSILVA, Juan Carlo S.-
dc.contributor.authorMARTINS, Felipe-
dc.contributor.authorGONCALVES, Andre N. A.-
dc.contributor.authorCOSTA-MARTINS, Andre G.-
dc.contributor.authorARAUJO, Jose D.-
dc.contributor.authorVIEGAS, Ana Carolina-
dc.contributor.authorCUNHA, Fernando Q.-
dc.contributor.authorFARSKY, Sandra-
dc.contributor.authorBOZZA, Fernando A.-
dc.contributor.authorLEVIN, Anna S.-
dc.contributor.authorPANNARAJ, Pia S.-
dc.contributor.authorI, Thushan de Silva-
dc.contributor.authorMINOPRIO, Paola-
dc.contributor.authorSILVA, Fabiano Pinheiro da-
dc.contributor.authorANDRADE, Bruno B.-
dc.contributor.authorI, Helder Nakaya-
dc.date.accessioned2022-02-24T17:16:06Z-
dc.date.available2022-02-24T17:16:06Z-
dc.date.issued2021-
dc.identifier.citationINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.105, p.579-587, 2021-
dc.identifier.issn1201-9712-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/44456-
dc.description.abstractBackground: The progression and severity of COVID-19 vary significantly in the population. While the hallmarks of SARS-CoV-2 and severe COVID-19 within routine laboratory parameters are emerging, the impact of sex and age on these profiles is still unknown. Methods: A multidimensional analysis was performed involving millions of records of laboratory parameters and diagnostic tests for 178 887 individuals from Brazil, of whom 33 266 tested positive for SARS-CoV-2. Analyzed data included those relating to complete blood cell count, electrolytes, metabolites, arterial blood gases, enzymes, hormones, cancer biomarkers, and others. Findings: COVID-19 induced similar alterations in laboratory parameters in males and females. CRP and ferritin were increased, especially in older men with COVID-19, whereas abnormal liver function tests were common across several age groups, except for young women. Low peripheral blood basophils and eosinophils were more common in the elderly with COVID-19. Both male and female COVID-19 patients admitted to intensive care units displayed alterations in the coagulation system, and higher values for neutrophils, CRP, and lactate dehydrogenase. Conclusions: Our study uncovered the laboratory profiles of a large cohort of COVID-19 patients, which formed the basis of discrepancies influenced by aging and biological sex. These profiles directly linked COVID-19 disease presentation to an intricate interplay between sex, age, and immune activation.eng
dc.language.isoeng-
dc.publisherELSEVIER SCI LTDeng
dc.relation.ispartofInternational Journal of Infectious Diseases-
dc.rightsopenAccesseng
dc.subjectCOVID-19eng
dc.subjectNeutrophilseng
dc.subjectSex differenceseng
dc.subjectCoagulopathyeng
dc.subjectInfectioneng
dc.subject.otheracute respiratory syndromeeng
dc.subject.othercovid-19eng
dc.titleIn-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19*eng
dc.typearticleeng
dc.rights.holderCopyright ELSEVIER SCI LTDeng
dc.identifier.doi10.1016/j.ijid.2021.03.016-
dc.identifier.pmid33713813-
dc.subject.wosInfectious Diseaseseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalGONZALEZ-DIAS, Patricia:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil-
hcfmusp.author.externalCASTRO, Icaro:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil-
hcfmusp.author.externalOGAVA, Rodrigo L. T.:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil-
hcfmusp.author.externalGIDDALURU, Jeevan:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil-
hcfmusp.author.externalSILVA, Juan Carlo S.:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil-
hcfmusp.author.externalMARTINS, Felipe:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil-
hcfmusp.author.externalGONCALVES, Andre N. A.:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil; Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo, Brazil-
hcfmusp.author.externalCOSTA-MARTINS, Andre G.:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil; Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo, Brazil-
hcfmusp.author.externalARAUJO, Jose D.:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil-
hcfmusp.author.externalVIEGAS, Ana Carolina:Univ Fed Sao Paulo, Sch Med, Med Dept, Div Nephrol, Sao Paulo, Brazil-
hcfmusp.author.externalCUNHA, Fernando Q.:Univ Sao Paulo, Ctr Res Inflammatory Dis CRID, Ribeirao Preto, SP, Brazil-
hcfmusp.author.externalFARSKY, Sandra:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil-
hcfmusp.author.externalBOZZA, Fernando A.:DOr Inst Res & Educ, Sao Paulo, SP, Brazil-
hcfmusp.author.externalPANNARAJ, Pia S.:Univ Southern Calif, Childrens Hosp Los Angeles, Div Infect Dis, Los Angeles, CA 90007 USA; Univ Southern Calif, Keck Sch Med, Dept Pediat Mol Microbiol & Immunol, Los Angeles, CA 90007 USA-
hcfmusp.author.externalI, Thushan de Silva:Univ Sheffield, Florey Inst Hostpathogen Interact, Sheffield, S Yorkshire, England; Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England-
hcfmusp.author.externalMINOPRIO, Paola:Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo, Brazil-
hcfmusp.author.externalANDRADE, Bruno B.:Fundacao Oswaldo Cruz, Inst Goncalo Moniz, BR-40296710 Salvador, BA, Brazil-
hcfmusp.author.externalI, Helder Nakaya:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil; Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo, Brazil; Univ Sao Paulo, Ctr Res Inflammatory Dis CRID, Ribeirao Preto, SP, Brazil-
hcfmusp.description.beginpage579-
hcfmusp.description.endpage587-
hcfmusp.description.volume105-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000644645900041-
hcfmusp.origem.id2-s2.0-85103093848-
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1878-3511-
hcfmusp.citation.scopus10-
hcfmusp.scopus.lastupdate2022-09-23-
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Artigos e Materiais de Revistas Científicas - COVID-19
COVID-19

Artigos e Materiais de Revistas Científicas - FM/MIP
Departamento de Moléstias Infecciosas e Parasitárias - FM/MIP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/46
LIM/46 - Laboratório de Parasitologia Médica

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Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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