Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/44572
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorDUARTE-NETO, Amaro Nunes-
dc.contributor.authorSILVA, Luiz Fernando Ferraz da-
dc.contributor.authorMONTEIRO, Renata Aparecida de Almeida-
dc.contributor.authorFILHO, Jair Theodoro-
dc.contributor.authorLEITE, Thabata Larissa Luciano Ferreira-
dc.contributor.authorMOURA, Catia Sales de-
dc.contributor.authorGOMES-GOUVEA, Michele Soares-
dc.contributor.authorPINHO, Joao Renato Rebellho-
dc.contributor.authorKANAMURA, Cristina Takami-
dc.contributor.authorOLIVERIA, Ellen Pierre de-
dc.contributor.authorBISPO, Kely Cristina Soares-
dc.contributor.authorARRUDA, Cassia-
dc.contributor.authorSANTOS, Aline Brito dos-
dc.contributor.authorAQUINO, Flavia Cristina Goncalves-
dc.contributor.authorCALDINI, Elia Garcia-
dc.contributor.authorMAUAD, Thais-
dc.contributor.authorSALDIVA, Paulo Hilario Nascimento-
dc.contributor.authorDOLHNIKOFF, Marisa-
dc.date.accessioned2022-02-24T17:19:12Z-
dc.date.available2022-02-24T17:19:12Z-
dc.date.issued2021-
dc.identifier.citationCLINICAL INFECTIOUS DISEASES, v.73, suppl.5, p.S442-S453, 2021-
dc.identifier.issn1058-4838-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/44572-
dc.description.abstractBackground: Minimally invasive autopsies, also known as minimally invasive tissue sampling (MITS), have proven to be an alternative to complete diagnostic autopsies (CDAs) in places or situations where this procedure cannot be performed. During the coronavirus disease 2019 (COVID-19) pandemic, CDAs were suspended by March 2020 in Brazil to reduce biohazard. To contribute to the understanding of COVID-19 pathology, we have conducted ultrasound (US)-guided MITS as a strategy. Methods: This case series study includes 80 autopsies performed in patients with COVID-19 confirmed by laboratorial tests. Different organs were sampled using a standardized MITS protocol. Tissues were submitted to histopathological analysis as well as immunohistochemical and molecular analysis and electron microscopy in selected cases. Results: US-guided MITS proved to be a safe and highly accurate procedure; none of the personnel were infected, and accuracy ranged from 69.1% for kidney, up to 90.1% for lungs, and reaching 98.7% and 97.5% for liver and heart, respectively. US-guided MITS provided a systemic view of the disease, describing the most common pathological findings and identifying viral and other infectious agents using ancillary techniques, and also allowed COVID-19 diagnosis confirmation in 5% of the cases that were negative in premortem and postmortem nasopharyngeal/oropharyngeal swab real-time reverse-transcription polymerase chain reaction. Conclusions: Our data showed that US-guided MITS has the capacity similar to CDA not only to identify but also to characterize emergent diseases.eng
dc.description.sponsorshipBill & Melinda Gates FoundationBill & Melinda Gates FoundationCGIAR [INV-002396]-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e TecnologicoConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [401825/20205, 304987/2017-4, 304277/2019-3]-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/17159-2]-
dc.description.sponsorshipHospital das Clinicas da Faculdade de Medicina da Universidade de PauloHC Convida [HC-024-2020]-
dc.description.sponsorshipBrazilian National Council for Scientific and Technological DevelopmentConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)-
dc.language.isoeng-
dc.publisherOXFORD UNIV PRESS INCeng
dc.relation.ispartofClinical Infectious Diseases-
dc.rightsrestrictedAccesseng
dc.subjectminimally invasive autopsyeng
dc.subjectCOVID-19eng
dc.subjectpathologyeng
dc.subjectultrasound guided biopsyeng
dc.subjectminimally invasive tissue samplingeng
dc.subjectautopsy safetyeng
dc.titleUltrasound-Guided Minimally Invasive Tissue Sampling: A Minimally Invasive Autopsy Strategy During the COVID-19 Pandemic in Brazil, 2020eng
dc.typearticleeng
dc.rights.holderCopyright OXFORD UNIV PRESS INCeng
dc.identifier.doi10.1093/cid/ciab885-
dc.identifier.pmid34910174-
dc.subject.wosImmunologyeng
dc.subject.wosInfectious Diseaseseng
dc.subject.wosMicrobiologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalLEITE, Thabata Larissa Luciano Ferreira:Univ Sao Paulo, Dept Patol, Lab Invest Med 05, Brazilian Image Autopsy Study Grp,Fac Med, Sao Paulo, Brazil-
hcfmusp.author.externalMOURA, Catia Sales de:Univ Sao Paulo, Dept Patol, Lab Invest Med 05, Brazilian Image Autopsy Study Grp,Fac Med, Sao Paulo, Brazil-
hcfmusp.author.externalKANAMURA, Cristina Takami:Adolfo Lutz Inst, Sao Paulo, Brazil-
hcfmusp.author.externalOLIVERIA, Ellen Pierre de:Inst Coracao, Dept Cardiopneumol, Sao Paulo, Brazil-
hcfmusp.description.beginpageS442-
hcfmusp.description.endpageS453-
hcfmusp.description.issuesuppl 5-
hcfmusp.description.volume73-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000736135300017-
hcfmusp.origem.id2-s2.0-85122772125-
hcfmusp.publisher.cityCARYeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1537-6591-
hcfmusp.citation.scopus0-
hcfmusp.scopus.lastupdate2022-07-14-
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