Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorDUARTE-NETO, Amaro Nunes-
dc.contributor.authorSILVA, Luiz Fernando Ferraz da-
dc.contributor.authorMONTEIRO, Renata Aparecida de Almeida-
dc.contributor.authorFILHO, Jair Theodoro-
dc.contributor.authorLEITE, Thabata Larissa Luciano Ferreira-
dc.contributor.authorMOURA, Catia Sales de-
dc.contributor.authorGOMES-GOUVEA, Michele Soares-
dc.contributor.authorPINHO, Joao Renato Rebellho-
dc.contributor.authorKANAMURA, Cristina Takami-
dc.contributor.authorOLIVERIA, Ellen Pierre de-
dc.contributor.authorBISPO, Kely Cristina Soares-
dc.contributor.authorARRUDA, Cassia-
dc.contributor.authorSANTOS, Aline Brito dos-
dc.contributor.authorAQUINO, Flavia Cristina Goncalves-
dc.contributor.authorCALDINI, Elia Garcia-
dc.contributor.authorMAUAD, Thais-
dc.contributor.authorSALDIVA, Paulo Hilario Nascimento-
dc.contributor.authorDOLHNIKOFF, Marisa-
dc.identifier.citationCLINICAL INFECTIOUS DISEASES, v.73, suppl.5, p.S442-S453, 2021-
dc.description.abstractBackground: Minimally invasive autopsies, also known as minimally invasive tissue sampling (MITS), have proven to be an alternative to complete diagnostic autopsies (CDAs) in places or situations where this procedure cannot be performed. During the coronavirus disease 2019 (COVID-19) pandemic, CDAs were suspended by March 2020 in Brazil to reduce biohazard. To contribute to the understanding of COVID-19 pathology, we have conducted ultrasound (US)-guided MITS as a strategy. Methods: This case series study includes 80 autopsies performed in patients with COVID-19 confirmed by laboratorial tests. Different organs were sampled using a standardized MITS protocol. Tissues were submitted to histopathological analysis as well as immunohistochemical and molecular analysis and electron microscopy in selected cases. Results: US-guided MITS proved to be a safe and highly accurate procedure; none of the personnel were infected, and accuracy ranged from 69.1% for kidney, up to 90.1% for lungs, and reaching 98.7% and 97.5% for liver and heart, respectively. US-guided MITS provided a systemic view of the disease, describing the most common pathological findings and identifying viral and other infectious agents using ancillary techniques, and also allowed COVID-19 diagnosis confirmation in 5% of the cases that were negative in premortem and postmortem nasopharyngeal/oropharyngeal swab real-time reverse-transcription polymerase chain reaction. Conclusions: Our data showed that US-guided MITS has the capacity similar to CDA not only to identify but also to characterize emergent diseases.eng
dc.description.sponsorshipBill & Melinda Gates FoundationBill & Melinda Gates FoundationCGIAR [INV-002396]-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e TecnologicoConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [401825/20205, 304987/2017-4, 304277/2019-3]-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/17159-2]-
dc.description.sponsorshipHospital das Clinicas da Faculdade de Medicina da Universidade de PauloHC Convida [HC-024-2020]-
dc.description.sponsorshipBrazilian National Council for Scientific and Technological DevelopmentConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)-
dc.publisherOXFORD UNIV PRESS INCeng
dc.relation.ispartofClinical Infectious Diseases-
dc.subjectminimally invasive autopsyeng
dc.subjectultrasound guided biopsyeng
dc.subjectminimally invasive tissue samplingeng
dc.subjectautopsy safetyeng
dc.titleUltrasound-Guided Minimally Invasive Tissue Sampling: A Minimally Invasive Autopsy Strategy During the COVID-19 Pandemic in Brazil, 2020eng
dc.rights.holderCopyright OXFORD UNIV PRESS INCeng
dc.subject.wosInfectious Diseaseseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Thabata Larissa Luciano Ferreira:Univ Sao Paulo, Dept Patol, Lab Invest Med 05, Brazilian Image Autopsy Study Grp,Fac Med, Sao Paulo, Brazil-, Catia Sales de:Univ Sao Paulo, Dept Patol, Lab Invest Med 05, Brazilian Image Autopsy Study Grp,Fac Med, Sao Paulo, Brazil-, Cristina Takami:Adolfo Lutz Inst, Sao Paulo, Brazil-, Ellen Pierre de:Inst Coracao, Dept Cardiopneumol, Sao Paulo, Brazil-
hcfmusp.description.issuesuppl 5-
hcfmusp.relation.referenceBasso C, 2020, EUR HEART J, V41, P3827, DOI 10.1093/eurheartj/ehaa664eng
hcfmusp.relation.referenceBeasley MB, 2002, ARCH PATHOL LAB MED, V126, P1064eng
hcfmusp.relation.referenceBryce C, 2021, MODERN PATHOL, V34, P1456, DOI 10.1038/s41379-021-00793-yeng
hcfmusp.relation.referenceCastillo P, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002171eng
hcfmusp.relation.referenceCastillo P, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132057eng
hcfmusp.relation.referenceCenters for Disease Control and Prevention, 2020, COLL SUBM POSTM SPECeng
hcfmusp.relation.referenceCenters for Disease Control and Prevention, 2021, COR DIS 2019 COVID 1eng
hcfmusp.relation.referenceCopin MC, 2020, INTENS CARE MED, V46, P1124, DOI 10.1007/s00134-020-06057-8eng
hcfmusp.relation.referenceCorman VM, 2020, EUROSURVEILLANCE, V25, P23, DOI 10.2807/1560-7917.ES.2020.25.3.2000045eng
hcfmusp.relation.referenceCox JA, 2014, BMC CLIN PATHOL, V14, DOI 10.1186/1472-6890-14-44eng
hcfmusp.relation.referenceCox JA, 2014, JAIDS-J ACQ IMM DEF, V67, P169, DOI 10.1097/QAI.0000000000000290eng
hcfmusp.relation.referenceMonteiro RAD, 2021, INTENS CARE MED, V47, P199, DOI 10.1007/s00134-020-06328-4eng
hcfmusp.relation.referenceDolhnikoff M, 2020, LANCET CHILD ADOLESC, V4, P790, DOI 10.1016/S2352-4642(20)30257-1eng
hcfmusp.relation.referenceDolhnikoff M, 2020, J THROMB HAEMOST, V18, P1517, DOI 10.1111/jth.14844eng
hcfmusp.relation.referenceDuarte-Neto AN, 2020, HISTOPATHOLOGY, V77, P186, DOI 10.1111/his.14160eng
hcfmusp.relation.referenceDuarte-Neto AN, 2021, ECLINICALMEDICINE, V35, DOI 10.1016/j.eclinm.2021.100850eng
hcfmusp.relation.referenceDuarte-Neto AN, 2019, PLOS NEGLECT TROP D, V13, DOI 10.1371/journal.pntd.0007625eng
hcfmusp.relation.referenceFerigato S, 2020, LANCET, V396, P1636, DOI [10.1016/S0140-6736(20)32164-4, 10.1016/S0140-6736(20)32376-X]eng
hcfmusp.relation.referenceMatuck BF, 2021, J ORAL MICROBIOL, V13, DOI 10.1080/20002297.2020.1848135eng
hcfmusp.relation.referenceFlikweert AW, 2020, J CRIT CARE, V59, P149, DOI 10.1016/j.jcrc.2020.07.002eng
hcfmusp.relation.referenceHooper JE, 2021, ARCH PATHOL LAB MED, V145, DOI 10.5858/arpa.2020-0786-SAeng
hcfmusp.relation.referenceHorby P, 2021, NEW ENGL J MED, V384, P693, DOI [10.1056/NEJMoa2022926, 10.1056/NEJMoa2021436]eng
hcfmusp.relation.referenceMaiese A, 2021, FORENSIC SCI MED PAT, V17, P279, DOI 10.1007/s12024-020-00310-8eng
hcfmusp.relation.referenceMartines RB, 2020, EMERG INFECT DIS, V26, P2005, DOI 10.3201/eid2609.202095eng
hcfmusp.relation.referenceMatuck BF, 2021, J PATHOL, V254, P239, DOI 10.1002/path.5679eng
hcfmusp.relation.referenceMauad T, 2021, RESP RES, V22, DOI 10.1186/s12931-021-01628-9eng
hcfmusp.relation.referenceMauad T, 2018, BMC PULM MED, V18, DOI 10.1186/s12890-018-0615-7eng
hcfmusp.relation.referenceMenter T, 2020, HISTOPATHOLOGY, V77, P198, DOI 10.1111/his.14134eng
hcfmusp.relation.referenceNegri EM, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.573044eng
hcfmusp.relation.referencePaganelli CR, 2020, GLOBAL HEALTH ACTION, V13, DOI 10.1080/16549716.2020.1792682eng
hcfmusp.relation.referenceParra-Medina R, 2021, ACTA HAEMATOL-BASEL, V144, P476, DOI 10.1159/000515104eng
hcfmusp.relation.referenceRakislova N, 2021, PATHOGENS, V10, DOI 10.3390/pathogens10040412eng
hcfmusp.relation.referenceSOPER F. L., 1938, TRAM ROY SOC TROP MED AND HYG, V32, P297, DOI 10.1016/S0035-9203(38)90045-8eng
hcfmusp.relation.referenceSoper FL, 1942, REV PANAM SALUD PUBL, V21, P1207eng
hcfmusp.relation.referenceTian SF, 2020, MODERN PATHOL, V33, P1007, DOI 10.1038/s41379-020-0536-xeng
hcfmusp.relation.referencevan Arkel ALE, 2020, AM J RESP CRIT CARE, V202, P132, DOI 10.1164/rccm.202004-1038LEeng
hcfmusp.relation.referenceVasquez-Bonilla WO, 2020, HUM PATHOL, V105, P74, DOI 10.1016/j.humpath.2020.07.023eng
hcfmusp.relation.referenceWong EB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047542eng
hcfmusp.relation.referenceWorld Health Organization, 2021, COR DIS 2019 COVID 1eng
Appears in Collections:

Artigos e Materiais de Revistas Científicas - COVID-19

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - IMT
Instituto de Medicina Tropical - IMT

Artigos e Materiais de Revistas Científicas - LIM/03
LIM/03 - Laboratório de Medicina Laboratorial

Artigos e Materiais de Revistas Científicas - LIM/05
LIM/05 - Laboratório de Poluição Atmosférica Experimental

Artigos e Materiais de Revistas Científicas - LIM/06
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses

Artigos e Materiais de Revistas Científicas - LIM/07
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental

Artigos e Materiais de Revistas Científicas - LIM/59
LIM/59 - Laboratório de Biologia Celular

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion (English)0 BAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.