Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorSILVA-JUNIOR, Francisco Pereira da-
dc.contributor.authorALVES, Camila Oliveira dos Santos-
dc.contributor.authorSILVA, Sonia Maria Cesar Azevedo-
dc.contributor.authorBORGES, Vanderci-
dc.contributor.authorFERRAZ, Henrique Ballalai-
dc.contributor.authorROCHA, Maria Sheila Guimaraes-
dc.contributor.authorLIMONGI, Joao Carlos Papaterra-
dc.contributor.authorBARBOSA, Egberto Reis-
dc.contributor.authorAGUIAR, Patricia de Carvalho-
dc.identifier.citationNEUROLOGICAL SCIENCES, v.43, n.2, p.1061-1065, 2022-
dc.description.abstractBackground Although abnormal movements and postures are the hallmark of dystonia, non-motor symptoms (NMS) are common and negatively affect quality of life.ObjectivesThe aim of this study was to screen dystonia patients for NMS and analyze their association with clinical parameters, including motor disability. Methods Adult patients with idiopathic isolated dystonia were interviewed and examined. Dystonia severity was evaluated with the Fahn-Marsden Dystonia Rating Scale and the presence of NMS was assessed using a list of 29 complaints. Results A hundred and two patients (63.7% female) were enrolled. Dystonia began after 20 years of age in 61.8% and was focal or segmental in 82.8% of patients. Only eight patients (7.8%) had no NMS and 59.8% reported more than five. The most prevalent NMS were pain (72.5%) and anxiety (63.7%), followed by difficulty recalling information (44.1%), sadness/anhedonia (41.2%), and difficulty falling asleep (38.2%). No correlation was found between the total number of NMS and dystonia severity (p=0.18) or regular botulinum toxin use (p=0.66). The majority of NMS domains correlated with each other. Conclusions Our results confirm a high prevalence of NMS among dystonia patients, even in those with mild motor disability. The pathophysiology of NMS in dystonia remains to be completely understood.eng
dc.relation.ispartofNeurological Sciences-
dc.subjectSigns and symptomseng
dc.subject.othercervical dystoniaeng
dc.titleHigh prevalence of self-reported non-motor symptoms and lack of correlation with motor severity in adult patients with idiopathic isolated dystoniaeng
dc.rights.holderCopyright SPRINGER-VERLAG ITALIA SRLeng
dc.subject.wosClinical Neurologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Camila Oliveira dos Santos:Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil-, Sonia Maria Cesar Azevedo:Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, SP, Brazil; Hosp Servidor Publ Estadual, Sao Paulo, SP, Brazil-, Vanderci:Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, SP, Brazil-, Henrique Ballalai:Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, SP, Brazil-, Maria Sheila Guimaraes:Hosp Santa Marcelina, Sao Paulo, SP, Brazil-, Patricia de Carvalho:Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil; Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, SP, Brazil-
hcfmusp.relation.referenceAlbanese A, 2013, MOVEMENT DISORD, V28, P863, DOI 10.1002/mds.25475eng
hcfmusp.relation.referenceBURKE RE, 1985, NEUROLOGY, V35, P73, DOI 10.1212/WNL.35.1.73eng
hcfmusp.relation.referenceChaudhuri KR, 2015, PARKINSONISM RELAT D, V21, P287, DOI 10.1016/j.parkreldis.2014.12.031eng
hcfmusp.relation.referenceChaudhuri KR, 2010, MOVEMENT DISORD, V25, P704, DOI 10.1002/mds.22868eng
hcfmusp.relation.referenceChaudhuri KR, 2006, MOVEMENT DISORD, V21, P916, DOI 10.1002/mds.20844eng
hcfmusp.relation.referenceConte A, 2016, PARKINSONISM RELAT D, V22, pS111, DOI 10.1016/j.parkreldis.2015.09.001eng
hcfmusp.relation.referenceEggink H, 2019, PARKINSONISM RELAT D, V58, P50, DOI 10.1016/j.parkreldis.2018.08.008eng
hcfmusp.relation.referenceFerrazzano G, 2019, J NEUROL, V266, P2780, DOI 10.1007/s00415-019-09484-weng
hcfmusp.relation.referenceHan V, 2020, ACTA NEUROL SCAND, V142, P613, DOI 10.1111/ane.13304eng
hcfmusp.relation.referenceHentschel F, 2017, J NEURAL TRANSM, V124, P245, DOI 10.1007/s00702-016-1639-xeng
hcfmusp.relation.referenceHertenstein E, 2016, SLEEP MED REV, V26, P95, DOI 10.1016/j.smrv.2015.04.004eng
hcfmusp.relation.referenceKlingelhoefer L, 2019, ANN CLIN TRANSL NEUR, V6, P2054, DOI 10.1002/acn3.50900eng
hcfmusp.relation.referenceKuyper DJ, 2011, MOVEMENT DISORD, V26, P1206, DOI 10.1002/mds.23709eng
hcfmusp.relation.referenceLi SL, 2020, FRONT NEUROL, V11, DOI 10.3389/fneur.2020.00209eng
hcfmusp.relation.referenceMarek M, 2018, NEUROPSYCH DIS TREAT, V14, P2847, DOI 10.2147/NDT.S175193eng
hcfmusp.relation.referenceNiccolai L, 2020, J CLIN NEUROSCI, V74, P1, DOI 10.1016/j.jocn.2019.12.050eng
hcfmusp.relation.referenceNovaretti N, 2019, TREMOR OTHER HYPERK, V9, DOI 10.7916/fhnv-v355eng
hcfmusp.relation.referenceShukla AW, 2016, INT J NEUROSCI, V126, P928, DOI 10.3109/00207454.2015.1085035eng
hcfmusp.relation.referenceStamelou M, 2012, BRAIN, V135, P1668, DOI 10.1093/brain/awr224eng
hcfmusp.relation.referenceTinazzi M, 2019, PARKINSONISM RELAT D, V65, P252, DOI 10.1016/j.parkreldis.2019.06.009eng
hcfmusp.relation.referenceTorres JAKL, 2017, INT REV NEUROBIOL, V134, P1335, DOI 10.1016/bs.irn.2017.05.003eng
hcfmusp.relation.referenceYang J, 2017, BRAIN BEHAV, V7, DOI 10.1002/brb3.592eng
hcfmusp.relation.referenceZurowski M, 2013, MOVEMENT DISORD, V28, P914, DOI 10.1002/mds.25501eng
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/45
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion (English)554 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.