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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | FORNAZIERI, Marco Aurelio | - |
dc.contributor.author | KUBO, Henrique Kazuo Lima | - |
dc.contributor.author | FARIAS, Lisandra Coneglian de | - |
dc.contributor.author | SILVA, Adriano Morita Fernandes da | - |
dc.contributor.author | GARCIA, Ellen Cristine Duarte | - |
dc.contributor.author | SANTOS, Gustavo de Alcantara Lopes dos | - |
dc.contributor.author | PINNA, Fabio de Rezende | - |
dc.contributor.author | VOEGELS, Richard Louis | - |
dc.date.accessioned | 2022-02-24T17:20:43Z | - |
dc.date.available | 2022-02-24T17:20:43Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY, v.25, n.4, p.E557-E562, 2021 | - |
dc.identifier.issn | 1809-9777 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/44696 | - |
dc.description.abstract | Introduction Intra and postoperative bleeding are the most frequent and feared complications in adenotonsillectomy (AT). Tranexamic acid (TXA), which is known for its antifibrinolytic effects, has a proven benefit in reducing bleeding in hemorrhagic trauma and cardiac surgery; however, the effectiveness and timing of its application in AT have not yet been established. Objectives We aimed to evaluate the efficacy of TXA in controlling bleeding during and after AT and assess its possible adverse effects in children. Methods The present randomized, controlled, double-blind clinical trial included 63 children aged 2 to 12 years. They were randomly assigned to receive either intravenous TXA (10 mg/kg) or placebo 10 minutes before surgery. The volume of intraoperative bleeding, presence of postoperative bleeding, and adverse effects during and 8 hours after the surgery were assessed. Results No difference in bleeding volume was noted between the 2 groups (mean, 122.7ml in the TXA group versus 115.5ml in the placebo group, p = 0.36). No intraoperative or postoperative adverse effects were noted because of TXA use. Furthermore, no primary or secondary postoperative bleeding was observed in any of the participants. Conclusion In our pediatric sample, TXA (10mg/ kg) administration before AT was safely used, without any adverse effects. It did not reduce the bleeding volume in children during this type of surgery. Future studies should assess the use of higher doses of TXA and its administration at other time points before or during surgery. | eng |
dc.language.iso | eng | - |
dc.publisher | GEORG THIEME VERLAG KG | eng |
dc.relation.ispartof | International Archives of Otorhinolaryngology | - |
dc.rights | openAccess | eng |
dc.subject | tranexamic acid | eng |
dc.subject | adenoidectomy | eng |
dc.subject | tonsillectomy | eng |
dc.subject | adenotonsillectomy | eng |
dc.title | Effectiveness and Adverse Effects of Tranexamic Acid in Bleeding during Adenotonsillectomy: A Randomized, Controlled, Double-blind Clinical Trial | eng |
dc.type | article | eng |
dc.rights.holder | Copyright GEORG THIEME VERLAG KG | eng |
dc.identifier.doi | 10.1055/s-0040-1722255 | - |
dc.identifier.pmid | 34737827 | - |
dc.subject.wos | Otorhinolaryngology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | FORNAZIERI, Marco Aurelio:Univ Estadual Londrina, Dept Surg, Londrina, PR, Brazil; Pontificia Univ Catolica Parana, Dept Med, Londrina, PR, Brazil; Univ Sao Paulo, Dept Otorhinolaryngol, Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | KUBO, Henrique Kazuo Lima:Pontificia Univ Catolica Parana, Dept Med, Londrina, PR, Brazil | - |
hcfmusp.author.external | FARIAS, Lisandra Coneglian de:Pontificia Univ Catolica Parana, Dept Med, Londrina, PR, Brazil | - |
hcfmusp.author.external | SILVA, Adriano Morita Fernandes da:Univ Estadual Londrina, Dept Surg, Londrina, PR, Brazil; Pontificia Univ Catolica Parana, Dept Med, Londrina, PR, Brazil | - |
hcfmusp.author.external | GARCIA, Ellen Cristine Duarte:Univ Estadual Londrina, Dept Surg, Londrina, PR, Brazil | - |
hcfmusp.author.external | SANTOS, Gustavo de Alcantara Lopes dos:Ctr Londrinense Otorrinolaringol, Londrina, PR, Brazil | - |
hcfmusp.description.beginpage | E557 | - |
hcfmusp.description.endpage | E562 | - |
hcfmusp.description.issue | 4 | - |
hcfmusp.description.volume | 25 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000619631400003 | - |
hcfmusp.origem.id | 2-s2.0-85119140291 | - |
hcfmusp.origem.id | SCIELO:S1809-48642021000400557 | - |
hcfmusp.publisher.city | STUTTGART | eng |
hcfmusp.publisher.country | GERMANY | eng |
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dc.description.index | PubMed | eng |
dc.identifier.eissn | 1809-4864 | - |
hcfmusp.citation.scopus | 1 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOF Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/32 |
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