Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/4474
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorMARQUES, V. L. S.-
dc.contributor.authorGOMES, R. C.-
dc.contributor.authorVIOLA, G. R.-
dc.contributor.authorMAIA, M. M.-
dc.contributor.authorDURIGON, G. S.-
dc.contributor.authorAIKAWA, N. E.-
dc.contributor.authorSILVA, C. Artur-
dc.date.accessioned2014-01-28T22:31:07Z-
dc.date.available2014-01-28T22:31:07Z-
dc.date.issued2013-
dc.identifier.citationLUPUS, v.22, n.13, p.1409-1412, 2013-
dc.identifier.issn0961-2033-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/4474-
dc.description.abstractMeningitis is the main manifestation of cryptococcosis in adult systemic lupus erythematosus (SLE) patients, and other organs and systems, such as the lungs, are rarely affected in this fungal infection. To our knowledge, no case of pulmonary cryptococcosis has been described in the pediatric lupus population. Therefore, we report herein one patient with childhood SLE (C-SLE) and Sjogren's syndrome overlap that presented encapsulated Cryptococcus yeast cells in lung tissue. A 14-year-old girl was diagnosed with C-SLE. At the age of 16 years and 5 months, she presented with fever, cough and dyspnea, without headache, vomiting, and also without signs of meningeal irritation or other clinical manifestations. She was being treated with mycophenolate mofetil, hydroxychloroquine and prednisone. Chest radiography and chest computer tomography showed a single nodule in the left posterior apex and three nodular lesions in the left hemithorax respectively. Bronchoalveolar lavage and transbronchial biopsy were normal and without isolation of bacteria or fungi. Voriconazole was empirically introduced for 21 days. Fifteen days after the first biopsy, she underwent open thoracotomy with surgical left lung biopsy and was diagnosed with pulmonary cryptococcosis. Voriconazole was replaced with oral fluconazole and this antifungal therapy was maintained with improvement of clinical manifestations and without marked alteration of radiological images. In conclusion, we report the first case of pulmonary cryptococcosis in Sjogren's and C-SLE patient with a satisfactory clinical response to antifungal therapy. Fungal infections should be excluded in the presence of lung nodules and etiological identification is required for proper treatment.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2008/58238-4, 2011/12471-2]-
dc.description.sponsorshipConselho Nacional do Desenvolvimento Cientifico e Tecnologico (CNPQ) [302724/2011-7]-
dc.description.sponsorshipFederico Foundation-
dc.description.sponsorshipNucleo de Apoio a Pesquisa ""Saude da Crianca e do Adolescente"" da USP (NAP-CriAd)-
dc.language.isoeng-
dc.publisherSAGE PUBLICATIONS LTD-
dc.relation.ispartofLupus-
dc.rightsrestrictedAccess-
dc.subjectCryptococcosis-
dc.subjectpulmonary-
dc.subjectchildhood-systemic lupus erythematosus-
dc.subjectSjogren syndrome-
dc.subjectoverlap-
dc.subjectinfection-
dc.subject.othertomography-guided localization-
dc.subject.otherinvasive aspergillosis-
dc.subject.otherclassification-
dc.subject.othercriteria-
dc.subject.othernodules-
dc.subject.otherpatient-
dc.titlePulmonary cryptococcosis in childhood systemic lupus erythematosus and Sjogren syndrome overlap: a rare opportunistic infection-
dc.typearticle-
dc.rights.holderCopyright SAGE PUBLICATIONS LTD-
dc.identifier.doi10.1177/0961203313502859-
dc.identifier.pmid23985965-
dc.subject.wosRheumatology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalGOMES, R. C.:Univ Sao Paulo, Fac Med, Pediat Rheumatol Unit, BR-05508 Sao Paulo, Brazil-
hcfmusp.author.externalMAIA, M. M.:Univ Sao Paulo, Fac Med, Pediat Rheumatol Unit, BR-05508 Sao Paulo, Brazil-
hcfmusp.description.beginpage1409-
hcfmusp.description.endpage1412-
hcfmusp.description.issue13-
hcfmusp.description.volume22-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84887037670-
hcfmusp.origem.idWOS:000326011800014-
hcfmusp.publisher.cityLONDON-
hcfmusp.publisher.countryENGLAND-
hcfmusp.relation.referenceBrizendine KD, 2011, SEMIN RESP CRIT CARE, V32, P727, DOI 10.1055/s-0031-1295720-
hcfmusp.relation.referenceBrunner HI, 2008, ARTHRITIS RHEUM, V58, P556, DOI 10.1002/art.23204-
hcfmusp.relation.referenceCanova EG, 2002, CLIN EXP RHEUMATOL, V20, P736-
hcfmusp.relation.referenceCavalcante EG, 2013, REV BRAS RH IN PRESS-
hcfmusp.relation.referenceChen HS, 2007, RHEUMATOLOGY, V46, P539, DOI 10.1093/rheumatology/kel343-
hcfmusp.relation.referenceFaco MMM, 2007, BRAZ J MED BIOL RES, V40, P993, DOI 10.1590/S0100-879X2006005000110-
hcfmusp.relation.referenceFranca CMP, 2012, ACTA REUMATOL PORT, V37, P276-
hcfmusp.relation.referenceGladman DD, 2002, J RHEUMATOL, V29, P288-
hcfmusp.relation.referenceGonzalez LA, 2010, LUPUS, V19, P639, DOI 10.1177/0961203309356458-
hcfmusp.relation.referenceHeran MKS, 2011, J PEDIATR SURG, V46, P1292, DOI 10.1016/j.jpedsurg.2011.02.043-
hcfmusp.relation.referenceHochberg MC, 1997, ARTHRITIS RHEUM, V40, P1725, DOI 10.1002/art.1780400928-
hcfmusp.relation.referenceInoue Y, 2007, INTERNAL MED, V46, P519, DOI 10.2169/internalmedicine.46.6249-
hcfmusp.relation.referenceJENSEN WA, 1985, AM REV RESPIR DIS, V132, P189-
hcfmusp.relation.referenceLin CM, 2006, J INFECTION, V53, P55-
hcfmusp.relation.referenceMu Xiang-dong, 2008, Zhonghua Jiehe He Huxi Zazhi, V31, P360-
hcfmusp.relation.referenceNakashima S, 2010, ANN THORAC SURG, V89, P212, DOI 10.1016/j.athoracsur.2009.09.075-
hcfmusp.relation.referencePerfect JR, 2010, CLIN INFECT DIS, V50, P291, DOI 10.1086/649858-
hcfmusp.relation.referenceQu YJ, 2012, ACTA RADIOL, V53, P668, DOI 10.1258/ar.2012.110612-
hcfmusp.relation.referenceSchattner A, 2004, RHEUMATOLOGY, V43, P111, DOI 10.1093/rheumatology/keg432-
hcfmusp.relation.referenceSilva MF, 2012, LUPUS, V21, P1011, DOI 10.1177/0961203312442752-
hcfmusp.relation.referenceVitali C, 2002, ANN RHEUM DIS, V61, P554, DOI 10.1136/ard.61.6.554-
dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.remissive.sponsorshipFederico Foundation-
hcfmusp.remissive.sponsorshipUSP-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.remissive.sponsorshipFederico Foundation-
hcfmusp.remissive.sponsorshipUSP-
hcfmusp.citation.scopus3-
hcfmusp.scopus.lastupdate2022-06-24-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICr
Instituto da Criança - HC/ICr

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica


Files in This Item:
File Description SizeFormat 
art_MARQUES_Pulmonary_cryptococcosis_in_childhood_systemic_lupus_erythematosus_and_2013.PDF
  Restricted Access
publishedVersion (English)97.43 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.