Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/455
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | BENSENOR, Isabela M. | - |
dc.contributor.author | OLMOS, Rodrigo D. | - |
dc.contributor.author | LOTUFO, Paulo A. | - |
dc.date.accessioned | 2013-07-30T14:41:49Z | - |
dc.date.available | 2013-07-30T14:41:49Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | CLINICAL INTERVENTIONS IN AGING, v.7, p.97-111, 2012 | - |
dc.identifier.issn | 1176-9092 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/455 | - |
dc.description.abstract | Thyroid disorders are highly prevalent, occurring most frequently in aging women. Thyroid-associated symptoms are very similar to symptoms of the aging process; thus, improved methods for diagnosing overt and subclinical hypothyroidism in elderly people are crucial. Thyrotropin measurement is considered to be the main test for detecting hypothyroidism. Combined evaluations of thyroid stimulating hormone (TSH) and free-thyroxine can detect overt hypothyroidism (high TSH with low free-thyroxine levels) and subclinical hypothyroidism (high TSH with normal free-thyroxine levels). It is difficult to confirm the diagnosis of thyroid diseases based only on symptoms, but presence of symptoms could be an indicator of who should be evaluated for thyroid function. The most important reasons to treat overt hypothyroidism are to relieve symptoms and avoid progression to myxedema. Overt hypothyroidism is classically treated using L-thyroxine; elderly patients require a low initial dose that is increased every 4 to 6 weeks until normalization of TSH levels. After stabilization, TSH levels are monitored yearly. There is no doubt about the indication for treatment of overt hypothyroidism, but indications for treatment of subclinical disease are controversial. Although treatment of subclinical hypothyroidism may result in lipid profile improvement, there is no evidence that this improvement is associated with decreased cardiovascular or all-cause mortality in elderly patients. In patients with a high risk of progression from subclinical to overt disease, close monitoring of thyroid function could be the best option. | - |
dc.language.iso | eng | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.relation.ispartof | Clinical Interventions in Aging | - |
dc.rights | openAccess | - |
dc.subject | overt hypothyroidism | - |
dc.subject | subclinical hypothyroidism | - |
dc.subject | diagnosis | - |
dc.subject | treatment | - |
dc.subject | elderly | - |
dc.subject.other | subclinical thyroid-dysfunction | - |
dc.subject.other | thyroxine plus triiodothyronine | - |
dc.subject.other | randomized controlled-trial | - |
dc.subject.other | placebo-controlled trial | - |
dc.subject.other | cardiovascular risk-factors | - |
dc.subject.other | ischemic-heart-disease | - |
dc.subject.other | quality-of-life | - |
dc.subject.other | double-blind | - |
dc.subject.other | older-adults | - |
dc.subject.other | cognitive function | - |
dc.title | Hypothyroidism in the elderly: diagnosis and management | - |
dc.type | article | - |
dc.rights.holder | Copyright DOVE MEDICAL PRESS LTD | - |
dc.identifier.doi | 10.2147/CIA.S23966 | - |
dc.identifier.pmid | 22573936 | - |
dc.subject.wos | Geriatrics & Gerontology | - |
dc.type.category | review | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.beginpage | 97 | - |
hcfmusp.description.endpage | 111 | - |
hcfmusp.description.volume | 7 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84862591669 | - |
hcfmusp.origem.id | WOS:000303472200001 | - |
hcfmusp.publisher.city | ALBANY | - |
hcfmusp.publisher.country | NEW ZEALAND | - |
hcfmusp.relation.reference | American Academy of Family Physicians, 2002, SUMM POL REC PER HLT | - |
hcfmusp.relation.reference | American Association of Clinical Endocrinologists, 2002, ENDOCR PRACT, V8, P457 | - |
hcfmusp.relation.reference | Helfand M, 1998, ANN INTERN MED, V129, P141 | - |
hcfmusp.relation.reference | Andersen S, 2002, J CLIN ENDOCR METAB, V87, P1068, DOI 10.1210/jc.87.3.1068 | - |
hcfmusp.relation.reference | Bauer DC, 2007, AM J MED, V120, P343, DOI 10.1016/j.amjmed.2006.04.034 | - |
hcfmusp.relation.reference | BEMBEN DA, 1994, J FAM PRACTICE, V38, P577 | - |
hcfmusp.relation.reference | BEMBEN DA, 1994, J FAM PRACTICE, V38, P583 | - |
hcfmusp.relation.reference | Bensenor Isabela, 2002, Sao Paulo Med J, V120, P146 | - |
hcfmusp.relation.reference | Bensenor IM, 2011, CAD SAUDE PUBLICA, V27, P155 | - |
hcfmusp.relation.reference | Biondi B, 2008, ENDOCR REV, V29, P76, DOI 10.1210/er.2006-0043 | - |
hcfmusp.relation.reference | Bjoro T, 2000, EUR J ENDOCRINOL, V143, P639, DOI 10.1530/eje.0.1430639 | - |
hcfmusp.relation.reference | Bunevicius R, 1999, NEW ENGL J MED, V340, P424, DOI 10.1056/NEJM199902113400603 | - |
hcfmusp.relation.reference | Bunevicius R, 2002, ENDOCRINE, V18, P129, DOI 10.1385/ENDO:18:2:129 | - |
hcfmusp.relation.reference | Canadian Task Force on the Periodic Health Examination, 1994, CAN GUID CLIN PREV H, P611 | - |
hcfmusp.relation.reference | Canaris GJ, 1997, J GEN INTERN MED, V12, P544, DOI 10.1046/j.1525-1497.1997.07109.x | - |
hcfmusp.relation.reference | Cappola AR, 2006, JAMA-J AM MED ASSOC, V295, P1033, DOI 10.1001/jama.295.9.1033 | - |
hcfmusp.relation.reference | Chen IJ, 2010, AM J EMERG MED, V28, P866 | - |
hcfmusp.relation.reference | Christ-Crain M, 2003, ATHEROSCLEROSIS, V166, P379, DOI 10.1016/S0021-9150(02)00372-6 | - |
hcfmusp.relation.reference | Clyde PW, 2003, JAMA-J AM MED ASSOC, V290, P2952, DOI 10.1001/jama.290.22.2952 | - |
hcfmusp.relation.reference | Compton WM, 2006, AM J PSYCHIAT, V163, P2141, DOI 10.1176/appi.ajp.163.12.2141 | - |
hcfmusp.relation.reference | Cooper DS, 2001, NEW ENGL J MED, V345, P260, DOI 10.1056/NEJM200107263450406 | - |
hcfmusp.relation.reference | COOPER DS, 1984, ANN INTERN MED, V101, P18 | - |
hcfmusp.relation.reference | DANFORTH E, 1989, ANNU REV NUTR, V9, P201, DOI 10.1146/annurev.nutr.9.1.201 | - |
hcfmusp.relation.reference | de Jongh RT, 2011, EUR J ENDOCRINOL, V165, P545, DOI 10.1530/EJE-11-0430 | - |
hcfmusp.relation.reference | Devdhar M, 2011, THYROID, V21, P821, DOI 10.1089/thy.2011.0029 | - |
hcfmusp.relation.reference | Diaz-Olmos R, 2010, SAO PAULO MED J, V128, P18, DOI 10.1590/S1516-31802010000100005 | - |
hcfmusp.relation.reference | Engum A, 2002, ACTA PSYCHIAT SCAND, V106, P27, DOI 10.1034/j.1600-0447.2002.01250.x | - |
hcfmusp.relation.reference | Escobar-Morreale HF, 2005, ANN INTERN MED, V142, P412 | - |
hcfmusp.relation.reference | Fazio S, 2004, RECENT PROG HORM RES, V59, P31, DOI 10.1210/rp.59.1.31 | - |
hcfmusp.relation.reference | Flatau E, 2000, EUR J EPIDEMIOL, V16, P43, DOI 10.1023/A:1007688113450 | - |
hcfmusp.relation.reference | Gebretsadik M, 2006, CURR PSYCHIAT REP, V8, P34 | - |
hcfmusp.relation.reference | Gharib H, 2005, THYROID, V15, P24, DOI 10.1089/thy.2005.15.24 | - |
hcfmusp.relation.reference | Glenn GC, 1996, ARCH PATHOL LAB MED, V120, P929 | - |
hcfmusp.relation.reference | Gopinath B, 2010, INTERN MED J, V40, P642, DOI 10.1111/j.1445-5994.2009.02156.x | - |
hcfmusp.relation.reference | Grabe HJ, 2005, ACTA PSYCHIAT SCAND, V112, P286, DOI 10.1111/j.1600-0447.2005.00586.x | - |
hcfmusp.relation.reference | Guralnik JM, 2004, BLOOD, V104, P2263, DOI 10.1182/blood-2004-05-1812 | - |
hcfmusp.relation.reference | Gussekloo J, 2004, JAMA-J AM MED ASSOC, V292, P2591, DOI 10.1001/jama.292.21.2591 | - |
hcfmusp.relation.reference | Hansen PS, 2004, J CLIN ENDOCR METAB, V89, P1181, DOI 10.1210/jc.2003-031641 | - |
hcfmusp.relation.reference | Helfand M, 1998, ANN INTERN MED, V129, P144 | - |
hcfmusp.relation.reference | Baskin H Jack, 2002, Endocr Pract, V8, P457 | - |
hcfmusp.relation.reference | Hollowell JG, 2002, J CLIN ENDOCR METAB, V87, P489, DOI 10.1210/jc.87.2.489 | - |
hcfmusp.relation.reference | Iqbal A, 2006, J INTERN MED, V260, P53, DOI 10.1111/j.1365-2796.2006.01652.x | - |
hcfmusp.relation.reference | Jaeschke R, 1996, J GEN INTERN MED, V11, P744, DOI 10.1007/BF02598988 | - |
hcfmusp.relation.reference | Jorde R, 2006, J CLIN ENDOCR METAB, V91, P145, DOI 10.1210/jc.2005-1775 | - |
hcfmusp.relation.reference | Kalra S, 2010, INJURY, V41, P385, DOI 10.1016/j.injury.2009.10.013 | - |
hcfmusp.relation.reference | Kanaya AM, 2002, ARCH INTERN MED, V162, P773, DOI 10.1001/archinte.162.7.773 | - |
hcfmusp.relation.reference | Klee GG, 1997, ENDOCRIN METAB CLIN, V26, P763, DOI 10.1016/S0889-8529(05)70281-4 | - |
hcfmusp.relation.reference | Kong WM, 2002, AM J MED, V112, P348, DOI 10.1016/S0002-9343(02)01022-7 | - |
hcfmusp.relation.reference | Ladenson PW, 2000, ARCH INTERN MED, V160, P1573, DOI 10.1001/archinte.160.11.1573 | - |
hcfmusp.relation.reference | Lee JS, 2010, ARCH INTERN MED, V170, P1876, DOI 10.1001/archinternmed.2010.424 | - |
hcfmusp.relation.reference | Ma C, 2009, NUCL MED COMMUN, V30, P586, DOI 10.1097/MNM.0b013e32832c79e0 | - |
hcfmusp.relation.reference | Magri F, 2002, METABOLISM, V51, P105, DOI 10.1053/meta.2002.28968 | - |
hcfmusp.relation.reference | MARIOTTI S, 1995, ENDOCR REV, V16, P686, DOI 10.1210/er.16.6.686 | - |
hcfmusp.relation.reference | Meier C, 2001, J CLIN ENDOCR METAB, V86, P4860, DOI 10.1210/jc.86.10.4860 | - |
hcfmusp.relation.reference | Mitrou P, 2011, MATURITAS, V70, P5, DOI 10.1016/j.maturitas.2011.05.016 | - |
hcfmusp.relation.reference | Nagasaki T, 2009, EUR J ENDOCRINOL, V160, P409, DOI 10.1530/EJE-08-0742 | - |
hcfmusp.relation.reference | Nystrom E, 1988, CLIN CHEM, V32, P603 | - |
hcfmusp.relation.reference | NYSTROM E, 1988, CLIN ENDOCRINOL, V29, P63, DOI 10.1111/j.1365-2265.1988.tb00250.x | - |
hcfmusp.relation.reference | Parle J, 2010, J CLIN ENDOCR METAB, V95, P3623, DOI 10.1210/jc.2009-2571 | - |
hcfmusp.relation.reference | PARLE JV, 1991, CLIN ENDOCRINOL, V34, P77 | - |
hcfmusp.relation.reference | Parle JV, 2001, LANCET, V358, P861, DOI 10.1016/S0140-6736(01)06067-6 | - |
hcfmusp.relation.reference | Patel KV, 2008, SEMIN HEMATOL, V45, P210, DOI 10.1053/j.seminhematol.2008.06.006 | - |
hcfmusp.relation.reference | PETERSEN K, 1991, J INTERN MED, V229, P407 | - |
hcfmusp.relation.reference | Pollock MA, 2001, BRIT MED J, V323, P891, DOI 10.1136/bmj.323.7318.891 | - |
hcfmusp.relation.reference | Razvi S, 2010, J CLIN ENDOCR METAB, V95, P1734, DOI 10.1210/jc.2009-1749 | - |
hcfmusp.relation.reference | Razvi S, 2007, J CLIN ENDOCR METAB, V92, P1715, DOI 10.1210/jc.2006-1869 | - |
hcfmusp.relation.reference | Razvi S, 2008, J CLIN ENDOCR METAB, V93, P2998, DOI 10.1210/jc.2008-0167 | - |
hcfmusp.relation.reference | Richardson WS, 2008, J GEN INTERN MED, V23, P87, DOI 10.1007/s11606-007-0330-1 | - |
hcfmusp.relation.reference | Rodondi N, 2005, ARCH INTERN MED, V165, P2460, DOI 10.1001/archinte.165.21.2460 | - |
hcfmusp.relation.reference | Roos A, 2005, ARCH INTERN MED, V165, P1714, DOI 10.1001/archinte.165.15.1714 | - |
hcfmusp.relation.reference | ROSENBAUM RL, 1982, ANN INTERN MED, V96, P53 | - |
hcfmusp.relation.reference | SAWIN CT, 1985, ARCH INTERN MED, V145, P1386, DOI 10.1001/archinte.145.8.1386 | - |
hcfmusp.relation.reference | Sgarbi JA, 2010, EUR J ENDOCRINOL, V162, P569, DOI 10.1530/EJE-09-0845 | - |
hcfmusp.relation.reference | Siegmund W, 2004, CLIN ENDOCRINOL, V60, P750, DOI 10.1111/j.1365-2265.2004.02050.x | - |
hcfmusp.relation.reference | Somwaru LL, 2011, J GERONTOL A-BIOL, V66, P809, DOI 10.1093/gerona/glr063 | - |
hcfmusp.relation.reference | Stone MB, 2003, MED COVERAGE ROUTINE | - |
hcfmusp.relation.reference | Surks MI, 2004, JAMA-J AM MED ASSOC, V291, P228, DOI 10.1001/jama.291.2.228 | - |
hcfmusp.relation.reference | Teixeira PDD, 2008, TRANSL RES, V151, P224, DOI 10.1016/j.trs1.2007.12.006 | - |
hcfmusp.relation.reference | Teixeira PFS, 2008, HORM METAB RES, V40, P50, DOI 10.1055/s-2007-993216 | - |
hcfmusp.relation.reference | TUNBRIDGE WMG, 1977, CLIN ENDOCRINOL, V7, P481, DOI 10.1111/j.1365-2265.1977.tb01340.x | - |
hcfmusp.relation.reference | US Preventive Services Task Force, SCREEN THYR DIS | - |
hcfmusp.relation.reference | van den Beld AW, 2005, J CLIN ENDOCR METAB, V90, P6403, DOI 10.1210/jc.2005-0872 | - |
hcfmusp.relation.reference | VANDERPUMP MPJ, 1995, CLIN ENDOCRINOL, V43, P55, DOI 10.1111/j.1365-2265.1995.tb01894.x | - |
hcfmusp.relation.reference | Vanderpump MPJ, 1996, BRIT MED J, V313, P539 | - |
hcfmusp.relation.reference | Walsh JP, 2003, J CLIN ENDOCR METAB, V88, P4543, DOI 10.1210/jc.2003-030249 | - |
hcfmusp.relation.reference | Wilson S, 2006, J CLIN ENDOCR METAB, V91, P4809, DOI 10.1210/jc.2006-1557 | - |
hcfmusp.relation.reference | Zulewski H, 1997, J CLIN ENDOCR METAB, V82, P771, DOI 10.1210/jc.82.3.771 | - |
dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 80 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_BENSENOR_Hypothyroidism_in_the_elderly_diagnosis_and_management_2012.PDF | publishedVersion (English) | 203.91 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.