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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | CHEN, Baixin | - |
dc.contributor.author | GUO, Miaolan | - |
dc.contributor.author | PEKER, Yueksel | - |
dc.contributor.author | SALORD, Neus | - |
dc.contributor.author | DRAGER, Luciano F. | - |
dc.contributor.author | LORENZI-FILHO, Geraldo | - |
dc.contributor.author | TANG, Xiangdong | - |
dc.contributor.author | LI, Yun | - |
dc.date.accessioned | 2022-04-19T12:56:14Z | - |
dc.date.available | 2022-04-19T12:56:14Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | JOURNAL OF CLINICAL MEDICINE, v.11, n.3, article ID 596, 10p, 2022 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/45832 | - |
dc.description.abstract | Background: Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of CPAP versus controls with >= 4 weeks treatment and reported pre- and post-intervention lipid profiles were included. Weighted mean difference (WMD) was used to assess the effect size. Meta-regression was used to explore the potential moderators of post-CPAP treatment changes in lipid profiles. Results: A total of 14 RCTs with 1792 subjects were included. CPAP treatment was associated with a significant decrease in total cholesterol compared to controls (WMD = -0.098 mmol/L, 95% CI = -0.169 to -0.027, p = 0.007, I-2 = 0.0%). No significant changes in triglyceride, high-density lipoprotein nor low-density lipoprotein were observed after CPAP treatment (all p > 0.2). Furthermore, meta-regression models showed that age, gender, body mass index, daytime sleepiness, OSA severity, follow-up study duration, CPAP compliance nor patients with cardiometabolic disease did not moderate the effects of CPAP treatment on lipid profiles (all p > 0.05). Conclusions: CPAP treatment decreases total cholesterol at a small magnitude but has no effect on other markers of dyslipidemia in OSA patients. Future studies of CPAP therapy should target combined treatment strategies with lifestyle modifications and/or anti-hyperlipidemic medications in the primary as well as secondary cardiovascular prevention models. | eng |
dc.description.sponsorship | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81970087] | - |
dc.description.sponsorship | Grant for Key Disciplinary Project of Clinical Medicine under the Guangdong High-level University Development Program | - |
dc.description.sponsorship | Guangdong Province Science and Technology Special Fund project [200115165870512] | - |
dc.description.sponsorship | Li Ka Shing Foundation Cross-Disciplinary Research Grant [2020LKSFG05B] | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | eng |
dc.relation.ispartof | Journal of Clinical Medicine | - |
dc.rights | openAccess | eng |
dc.subject | obstructive sleep apnea | eng |
dc.subject | continuous positive airway pressure | eng |
dc.subject | lipid profile | eng |
dc.subject | total cholesterol | eng |
dc.subject.other | chronic intermittent hypoxia | eng |
dc.subject.other | cardiovascular outcomes | eng |
dc.subject.other | blood-pressure | eng |
dc.subject.other | cpap | eng |
dc.subject.other | association | eng |
dc.subject.other | cortisol | eng |
dc.subject.other | stress | eng |
dc.subject.other | impact | eng |
dc.subject.other | males | eng |
dc.subject.other | risk | eng |
dc.title | Effect of Continuous Positive Airway Pressure on Lipid Profiles in Obstructive Sleep Apnea: A Meta-Analysis | eng |
dc.type | article | eng |
dc.rights.holder | Copyright MDPI | eng |
dc.identifier.doi | 10.3390/jcm11030596 | - |
dc.identifier.pmid | 35160050 | - |
dc.subject.wos | Medicine, General & Internal | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | CHEN, Baixin:Shantou Univ, Med Coll, Dept Sleep Med, Shantou Univ Mental Hlth Ctr, Shantou 515065, Peoples R China; Shantou Univ, Med Coll, Sleep Med Ctr, Shantou 515041, Peoples R China | - |
hcfmusp.author.external | GUO, Miaolan:Shantou Univ, Med Coll, Dept Nursing, Shantou 515041, Peoples R China | - |
hcfmusp.author.external | PEKER, Yueksel:Koc Univ, Dept Pulm Med, Sch Med, TR-34010 Istanbul, Turkey; Univ Gothenburg, Sahlgrenska Acad, S-40530 Gothenburg, Sweden; Lund Univ, Dept Clin Sci Resp Med & Allergol, Fac Med, S-22185 Lund, Sweden; Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Sch Med, Pittsburgh, PA 15213 USA | - |
hcfmusp.author.external | SALORD, Neus:Univ Barcelona, Multidisciplinary Sleep Unit, Dept Resp Med, Hosp Univ Bellvitge,IDIBELL,Hosp Llobregat, Barcelona 08907, Spain | - |
hcfmusp.author.external | TANG, Xiangdong:Sichuan Univ, Sleep Med Ctr, Translat Neurosci Ctr, West China Hosp, Chengdu 610041, Peoples R China | - |
hcfmusp.author.external | LI, Yun:Shantou Univ, Med Coll, Dept Sleep Med, Shantou Univ Mental Hlth Ctr, Shantou 515065, Peoples R China; Shantou Univ, Med Coll, Sleep Med Ctr, Shantou 515041, Peoples R China | - |
hcfmusp.description.articlenumber | 596 | - |
hcfmusp.description.issue | 3 | - |
hcfmusp.description.volume | 11 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000759598600001 | - |
hcfmusp.origem.id | 2-s2.0-85123380276 | - |
hcfmusp.publisher.city | BASEL | eng |
hcfmusp.publisher.country | SWITZERLAND | eng |
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dc.description.index | PubMed | eng |
dc.identifier.eissn | 2077-0383 | - |
hcfmusp.citation.scopus | 8 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/63 |
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