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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorCHEN, Baixin-
dc.contributor.authorGUO, Miaolan-
dc.contributor.authorPEKER, Yueksel-
dc.contributor.authorSALORD, Neus-
dc.contributor.authorDRAGER, Luciano F.-
dc.contributor.authorLORENZI-FILHO, Geraldo-
dc.contributor.authorTANG, Xiangdong-
dc.contributor.authorLI, Yun-
dc.date.accessioned2022-04-19T12:56:14Z-
dc.date.available2022-04-19T12:56:14Z-
dc.date.issued2022-
dc.identifier.citationJOURNAL OF CLINICAL MEDICINE, v.11, n.3, article ID 596, 10p, 2022-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/45832-
dc.description.abstractBackground: Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of CPAP versus controls with >= 4 weeks treatment and reported pre- and post-intervention lipid profiles were included. Weighted mean difference (WMD) was used to assess the effect size. Meta-regression was used to explore the potential moderators of post-CPAP treatment changes in lipid profiles. Results: A total of 14 RCTs with 1792 subjects were included. CPAP treatment was associated with a significant decrease in total cholesterol compared to controls (WMD = -0.098 mmol/L, 95% CI = -0.169 to -0.027, p = 0.007, I-2 = 0.0%). No significant changes in triglyceride, high-density lipoprotein nor low-density lipoprotein were observed after CPAP treatment (all p > 0.2). Furthermore, meta-regression models showed that age, gender, body mass index, daytime sleepiness, OSA severity, follow-up study duration, CPAP compliance nor patients with cardiometabolic disease did not moderate the effects of CPAP treatment on lipid profiles (all p > 0.05). Conclusions: CPAP treatment decreases total cholesterol at a small magnitude but has no effect on other markers of dyslipidemia in OSA patients. Future studies of CPAP therapy should target combined treatment strategies with lifestyle modifications and/or anti-hyperlipidemic medications in the primary as well as secondary cardiovascular prevention models.eng
dc.description.sponsorshipNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81970087]-
dc.description.sponsorshipGrant for Key Disciplinary Project of Clinical Medicine under the Guangdong High-level University Development Program-
dc.description.sponsorshipGuangdong Province Science and Technology Special Fund project [200115165870512]-
dc.description.sponsorshipLi Ka Shing Foundation Cross-Disciplinary Research Grant [2020LKSFG05B]-
dc.language.isoeng-
dc.publisherMDPIeng
dc.relation.ispartofJournal of Clinical Medicine-
dc.rightsopenAccesseng
dc.subjectobstructive sleep apneaeng
dc.subjectcontinuous positive airway pressureeng
dc.subjectlipid profileeng
dc.subjecttotal cholesteroleng
dc.subject.otherchronic intermittent hypoxiaeng
dc.subject.othercardiovascular outcomeseng
dc.subject.otherblood-pressureeng
dc.subject.othercpapeng
dc.subject.otherassociationeng
dc.subject.othercortisoleng
dc.subject.otherstresseng
dc.subject.otherimpacteng
dc.subject.othermaleseng
dc.subject.otherriskeng
dc.titleEffect of Continuous Positive Airway Pressure on Lipid Profiles in Obstructive Sleep Apnea: A Meta-Analysiseng
dc.typearticleeng
dc.rights.holderCopyright MDPIeng
dc.identifier.doi10.3390/jcm11030596-
dc.identifier.pmid35160050-
dc.subject.wosMedicine, General & Internaleng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalCHEN, Baixin:Shantou Univ, Med Coll, Dept Sleep Med, Shantou Univ Mental Hlth Ctr, Shantou 515065, Peoples R China; Shantou Univ, Med Coll, Sleep Med Ctr, Shantou 515041, Peoples R China-
hcfmusp.author.externalGUO, Miaolan:Shantou Univ, Med Coll, Dept Nursing, Shantou 515041, Peoples R China-
hcfmusp.author.externalPEKER, Yueksel:Koc Univ, Dept Pulm Med, Sch Med, TR-34010 Istanbul, Turkey; Univ Gothenburg, Sahlgrenska Acad, S-40530 Gothenburg, Sweden; Lund Univ, Dept Clin Sci Resp Med & Allergol, Fac Med, S-22185 Lund, Sweden; Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Sch Med, Pittsburgh, PA 15213 USA-
hcfmusp.author.externalSALORD, Neus:Univ Barcelona, Multidisciplinary Sleep Unit, Dept Resp Med, Hosp Univ Bellvitge,IDIBELL,Hosp Llobregat, Barcelona 08907, Spain-
hcfmusp.author.externalTANG, Xiangdong:Sichuan Univ, Sleep Med Ctr, Translat Neurosci Ctr, West China Hosp, Chengdu 610041, Peoples R China-
hcfmusp.author.externalLI, Yun:Shantou Univ, Med Coll, Dept Sleep Med, Shantou Univ Mental Hlth Ctr, Shantou 515065, Peoples R China; Shantou Univ, Med Coll, Sleep Med Ctr, Shantou 515041, Peoples R China-
hcfmusp.description.articlenumber596-
hcfmusp.description.issue3-
hcfmusp.description.volume11-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000759598600001-
hcfmusp.origem.id2-s2.0-85123380276-
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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dc.description.indexPubMedeng
dc.identifier.eissn2077-0383-
hcfmusp.citation.scopus0-
hcfmusp.scopus.lastupdate2022-07-07-
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