Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorHOKAMA, Larissa Tami-
dc.contributor.authorVEIGA, Alicia Dudy Muller-
dc.contributor.authorMENEZES, Maria Clara Saad-
dc.contributor.authorPINTO, Agnes Araujo Sardinha-
dc.contributor.authorLIMA, Thais Martins de-
dc.contributor.authorARIGA, Suely Kunimi Kubo-
dc.contributor.authorBARBEIRO, Hermes Vieira-
dc.contributor.authorBARBEIRO, Denise Frediani-
dc.contributor.authorMOREIRA, Claudia de Lucena-
dc.contributor.authorSTANZANI, Gabriela-
dc.contributor.authorBRANDAO, Rodrigo Antonio-
dc.contributor.authorMARCHINI, Julio Flavio-
dc.contributor.authorALENCAR, Julio Cesar-
dc.contributor.authorMARINO, Lucas Oliveira-
dc.contributor.authorGOMEZ, Luz Marina-
dc.contributor.authorSOUZA, Heraldo P.-
dc.identifier.citationMICROVASCULAR RESEARCH, v.140, article ID 104303, 5p, 2022-
dc.description.abstractSystemic inflammatory response, as observed in sepsis and severe COVID-19, may lead to endothelial damage. Therefore, we aim to compare the extent of endothelial injury and its relationship to inflammation in both diseases. We included patients diagnosed with sepsis (SEPSIS group, n = 21), mild COVID-19 (MILD group, n = 31), and severe COVID-19 (SEVERE group, n = 24). Clinical and routine laboratory data were obtained, circulating cytokines (INF-gamma, TNF-alpha, and IL-10) and endothelial injury markers (E-Selectin, Tissue Factor (TF) and von Willebrand factor (vWF)) were measured. Compared to the SEPSIS group, patients with severe COVID-19 present similar clinical and laboratory data, except for lower circulating IL-10 and E-Selectin levels. Compared to the MILD group, patients in the SEVERE group showed higher levels of TNF-alpha, IL-10, and TF. There was no clear relationship between cytokines and endothelial injury markers among the three studied groups; however, in SEVERE COVID-19 patients, there is a positive relationship between INF-gamma with TF and a negative relationship between IL-10 and vWF. In conclusion, COVID-19 and septic patients have a similar pattern of cytokines and endothelial dysfunction markers. These findings highlight the importance of endothelium dysfunction in COVID-19 and suggest that endothelium should be better evaluated as a therapeutic target for the disease.eng
dc.description.sponsorshipHospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo: Grant COVID-19, 2020-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP]Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2016-14566-4, 2020/04738-8]-
dc.relation.ispartofMicrovascular Research-
dc.subjectTissue Factoreng
dc.subjectvon Willebrand Factoreng
dc.subjectSystematic inflammationeng
dc.titleEndothelial injury in COVID-19 and septic patientseng
dc.rights.holderCopyright ACADEMIC PRESS INC ELSEVIER SCIENCEeng
dc.contributor.groupauthorEmergency Usp COVID-19 Grp-
dc.subject.wosPeripheral Vascular Diseaseeng
dc.type.categoryoriginal articleeng
hcfmusp.publisher.citySAN DIEGOeng
hcfmusp.relation.referenceAbebe W, 2010, EPMA J, V1, P32, DOI 10.1007/s13167-010-0012-7eng
hcfmusp.relation.referenceAnderson TJ, 1999, J AM COLL CARDIOL, V34, P631, DOI 10.1016/S0735-1097(99)00259-4eng
hcfmusp.relation.referenceAndrianto, 2021, MICROVASC RES, V138, DOI 10.1016/j.mvr.2021.104224eng
hcfmusp.relation.referenceDel Valle DM, 2020, NAT MED, V26, P1636, DOI 10.1038/s41591-020-1051-9eng
hcfmusp.relation.referenceInce C, 2016, SHOCK, V45, P259, DOI 10.1097/SHK.0000000000000473eng
hcfmusp.relation.referenceKlok FA, 2020, THROMB RES, V191, P145, DOI 10.1016/j.thromres.2020.04.013eng
hcfmusp.relation.referenceKruger-Genge A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184411eng
hcfmusp.relation.referenceLeentjens J, 2021, LANCET HAEMATOL, V8, DOI 10.1016/S2352-3026(21)00105-8eng
hcfmusp.relation.referenceLEEUWENBERG JFM, 1992, IMMUNOLOGY, V77, P543eng
hcfmusp.relation.referenceMACKMAN N, 1995, FASEB J, V9, P883, DOI 10.1096/fasebj.9.10.7615158eng
hcfmusp.relation.referenceMARCHANT A, 1995, J CLIN IMMUNOL, V15, P266, DOI 10.1007/BF01540884eng
hcfmusp.relation.referenceMartin-Fernandez M, 2020, BJS OPEN, V4, P524, DOI 10.1002/bjs5.50265eng
hcfmusp.relation.referenceMOORE KW, 1993, ANNU REV IMMUNOL, V11, P165, DOI 10.1146/annurev.immunol.11.1.165eng
hcfmusp.relation.referenceNicosia RF, 2021, AM J PATHOL, V191, P1374, DOI 10.1016/j.ajpath.2021.05.007eng
hcfmusp.relation.referencePober JS, 2007, NAT REV IMMUNOL, V7, P803, DOI 10.1038/nri2171eng
hcfmusp.relation.referenceRanzani OT, 2021, LANCET RESP MED, V9, P407, DOI 10.1016/S2213-2600(20)30560-9eng
hcfmusp.relation.referenceRidker PM, 1998, CIRCULATION, V98, P731, DOI 10.1161/01.CIR.98.8.731eng
hcfmusp.relation.referenceRosell A, 2021, ARTERIOSCL THROM VAS, V41, P878, DOI 10.1161/ATVBAHA.120.315547eng
hcfmusp.relation.referenceSeymour CW, 2017, NEW ENGL J MED, V376, P2235, DOI 10.1056/NEJMoa1703058eng
hcfmusp.relation.referenceSinger M, 2016, JAMA-J AM MED ASSOC, V315, P801, DOI 10.1001/jama.2016.0287eng
hcfmusp.relation.referenceSmadja DM, 2020, ANGIOGENESIS, V23, P611, DOI 10.1007/s10456-020-09730-0eng
hcfmusp.relation.referenceSungurlu S, 2020, CRIT CARE CLIN, V36, P255, DOI 10.1016/j.ccc.2019.12.002eng
hcfmusp.relation.referencevan der Poll T, 2017, NAT REV IMMUNOL, V17, P407, DOI 10.1038/nri.2017.36eng
hcfmusp.relation.referenceVarga Z, 2020, LANCET, V395, P1417, DOI 10.1016/S0140-6736(20)30937-5eng
hcfmusp.relation.referenceWang J, 2020, J LEUKOCYTE BIOL, V108, P17, DOI 10.1002/JLB.3COVR0520-272Reng
hcfmusp.relation.referenceWorld Health Organization, 2021, CLIN MAN COV 19 INTeng
hcfmusp.relation.referenceZhou P, 2020, NATURE, V588, pE6, DOI [10.1038/s41586-020-2951-z, 10.1038/s41586-020-2012-7]eng
Appears in Collections:

Artigos e Materiais de Revistas Científicas - COVID-19

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/02
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica

Artigos e Materiais de Revistas Científicas - LIM/38
LIM/38 - Laboratório de Epidemiologia e Imunobiologia

Artigos e Materiais de Revistas Científicas - LIM/51
LIM/51 - Laboratório de Emergências Clínicas

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion (English)620.56 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.