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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBARROSO, Wermerson Assuncao-
dc.contributor.authorSERRA, Mariana Barreto-
dc.contributor.authorABREU, Iracelle Carvalho-
dc.contributor.authorBARBEIRO, Hermes Vieira-
dc.contributor.authorFIAMONCINI, Jarlei-
dc.contributor.authorALVARENGA, Jose Fernando Rinaldi de-
dc.contributor.authorSOUZA, Heraldo Possolo de-
dc.contributor.authorLIMA, Thais Martins de-
dc.identifier.citationPHYTOTHERAPY RESEARCH, v.36, n.2, p.951-962, 2022-
dc.description.abstractWe investigate the effect of the banana green peels extract (BPE) as a preventive treatment against NAFLD in high-fat diet fed mice. Mice received daily doses of 100 or 250 mg/kg of BPE for 12 weeks along with the high-fat diet. BPE reduced weight gain (p < .0001), adipose tissue hypertrophy (p < .0001), and improved glucose homeostasis (p < .0001). Plasma levels of glucose-dependent insulinotropic polypeptide, triglycerides, total cholesterol, LDL-cholesterol, non-esterified fatty acids, aspartate and alanine transaminase, leptin, and resistin were decreased in BPE treated mice (p < .05). BPE effects on lipid metabolism were associated with decreased gene expression of lipogenic enzymes and increased expression of enzymes related to fatty acid and cholesterol degradation (p < .05). Plasma and liver bile acid (BA) profiles were modulated by BPE, with positive correlations between specific BA and UCP-1, CPT-1 and PGC-1 beta expression in brown adipose tissue (p < .05). BPE reduced hepatic steatosis and inflammation, possibly due to reduced p65 NF-kappa B nuclear translocation (p < .05) and modulation of oxidative stress (p < .05). These data indicate that BPE is a source of phytochemical compounds with promising effects toward the prevention of metabolic disorders associated with obesity.eng
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel SuperiorCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de S~ao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP 2013/07914-8, FAPESP 2015/19189-0, FAPESP 2017/12843-3, FAPESP 2019/11324-8]-
dc.relation.ispartofPhytotherapy Research-
dc.subjectbanana green peelseng
dc.subjectlipid metabolismeng
dc.subjectMusa cavendisheng
dc.subjectnonalcoholic fatty liver diseaseeng
dc.subjectoxidative stresseng
dc.titleBanana green peels extract protects against nonalcoholic fatty liver disease in high-fat-fed mice through modulation of lipid metabolism and inflammationeng
dc.rights.holderCopyright WILEYeng
dc.subject.wosChemistry, Medicinaleng
dc.subject.wosPharmacology & Pharmacyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Iracelle Carvalho:Univ Fed Maranhao, Physiol Sci Dept, Lab Res & Postgrad Pharmacol LPPF, Sao Luis, Maranhao, Brazil-, Jarlei:Univ Sao Paulo, Food Res Ctr FoRC, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Sao Paulo, SP, Brazil-, Jose Fernando Rinaldi de:Univ Sao Paulo, Food Res Ctr FoRC, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Sao Paulo, SP, Brazil-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/02
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica

Artigos e Materiais de Revistas Científicas - LIM/51
LIM/51 - Laboratório de Emergências Clínicas

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