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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBARROSO, Wermerson Assuncao-
dc.contributor.authorSERRA, Mariana Barreto-
dc.contributor.authorABREU, Iracelle Carvalho-
dc.contributor.authorBARBEIRO, Hermes Vieira-
dc.contributor.authorFIAMONCINI, Jarlei-
dc.contributor.authorALVARENGA, Jose Fernando Rinaldi de-
dc.contributor.authorSOUZA, Heraldo Possolo de-
dc.contributor.authorLIMA, Thais Martins de-
dc.date.accessioned2022-04-19T12:56:16Z-
dc.date.available2022-04-19T12:56:16Z-
dc.date.issued2022-
dc.identifier.citationPHYTOTHERAPY RESEARCH, v.36, n.2, p.951-962, 2022-
dc.identifier.issn0951-418X-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/45840-
dc.description.abstractWe investigate the effect of the banana green peels extract (BPE) as a preventive treatment against NAFLD in high-fat diet fed mice. Mice received daily doses of 100 or 250 mg/kg of BPE for 12 weeks along with the high-fat diet. BPE reduced weight gain (p < .0001), adipose tissue hypertrophy (p < .0001), and improved glucose homeostasis (p < .0001). Plasma levels of glucose-dependent insulinotropic polypeptide, triglycerides, total cholesterol, LDL-cholesterol, non-esterified fatty acids, aspartate and alanine transaminase, leptin, and resistin were decreased in BPE treated mice (p < .05). BPE effects on lipid metabolism were associated with decreased gene expression of lipogenic enzymes and increased expression of enzymes related to fatty acid and cholesterol degradation (p < .05). Plasma and liver bile acid (BA) profiles were modulated by BPE, with positive correlations between specific BA and UCP-1, CPT-1 and PGC-1 beta expression in brown adipose tissue (p < .05). BPE reduced hepatic steatosis and inflammation, possibly due to reduced p65 NF-kappa B nuclear translocation (p < .05) and modulation of oxidative stress (p < .05). These data indicate that BPE is a source of phytochemical compounds with promising effects toward the prevention of metabolic disorders associated with obesity.eng
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel SuperiorCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de S~ao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP 2013/07914-8, FAPESP 2015/19189-0, FAPESP 2017/12843-3, FAPESP 2019/11324-8]-
dc.language.isoeng-
dc.publisherWILEYeng
dc.relation.ispartofPhytotherapy Research-
dc.rightsrestrictedAccesseng
dc.subjectbanana green peelseng
dc.subjectinflammationeng
dc.subjectlipid metabolismeng
dc.subjectMusa cavendisheng
dc.subjectnonalcoholic fatty liver diseaseeng
dc.subjectoxidative stresseng
dc.subject.otherinsulin-resistanceeng
dc.subject.otherexpressioneng
dc.titleBanana green peels extract protects against nonalcoholic fatty liver disease in high-fat-fed mice through modulation of lipid metabolism and inflammationeng
dc.typearticleeng
dc.rights.holderCopyright WILEYeng
dc.identifier.doi10.1002/ptr.7366-
dc.identifier.pmid35018684-
dc.subject.wosChemistry, Medicinaleng
dc.subject.wosPharmacology & Pharmacyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalABREU, Iracelle Carvalho:Univ Fed Maranhao, Physiol Sci Dept, Lab Res & Postgrad Pharmacol LPPF, Sao Luis, Maranhao, Brazil-
hcfmusp.author.externalFIAMONCINI, Jarlei:Univ Sao Paulo, Food Res Ctr FoRC, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Sao Paulo, SP, Brazil-
hcfmusp.author.externalALVARENGA, Jose Fernando Rinaldi de:Univ Sao Paulo, Food Res Ctr FoRC, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Sao Paulo, SP, Brazil-
hcfmusp.description.beginpage951-
hcfmusp.description.endpage962-
hcfmusp.description.issue2-
hcfmusp.description.volume36-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000741283400001-
hcfmusp.origem.id2-s2.0-85122693446-
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAlvehus M, 2010, OBESITY, V18, P879, DOI 10.1038/oby.2010.22eng
hcfmusp.relation.referenceAmirinejad A, 2021, BMC COMPLEMENT MED, V21, DOI 10.1186/s12906-021-03396-xeng
hcfmusp.relation.referenceAmirinejad A, 2020, J SCI FOOD AGR, V100, P1787, DOI 10.1002/jsfa.10215eng
hcfmusp.relation.referenceBarroso WA, 2019, TOXICOL IN VITRO, V59, P179, DOI 10.1016/j.tiv.2019.04.020eng
hcfmusp.relation.referenceChung MY, 2012, J NUTR BIOCHEM, V23, P361, DOI 10.1016/j.jnutbio.2011.01.001eng
hcfmusp.relation.referenceEstes C, 2018, J HEPATOL, V69, P896, DOI 10.1016/j.jhep.2018.05.036eng
hcfmusp.relation.referenceFreedman BD, 2005, J BIOL CHEM, V280, P17118, DOI 10.1074/jbc.M407539200eng
hcfmusp.relation.referenceFromme T, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37464-zeng
hcfmusp.relation.referenceGerard P, 2016, CELL MOL LIFE SCI, V73, P147, DOI 10.1007/s00018-015-2061-5eng
hcfmusp.relation.referenceGhaffarzadegan T, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40272-8eng
hcfmusp.relation.referenceGu M, 2020, PHYTOTHER RES, V34, P3063, DOI 10.1002/ptr.6743eng
hcfmusp.relation.referenceHallsworth K, 2019, JHEP REP, V1, P468, DOI 10.1016/j.jhepr.2019.10.008eng
hcfmusp.relation.referenceHORIGOME T, 1992, BRIT J NUTR, V68, P231, DOI 10.1079/BJN19920080eng
hcfmusp.relation.referenceHuang FJ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12896-xeng
hcfmusp.relation.referenceKleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701eng
hcfmusp.relation.referenceLi TG, 2010, HEPATOLOGY, V52, P678, DOI 10.1002/hep.23721eng
hcfmusp.relation.referenceMeyer K, 2002, INT J ONCOL, V21, P1175eng
hcfmusp.relation.referenceNair Anroop B, 2016, J Basic Clin Pharm, V7, P27, DOI 10.4103/0976-0105.177703eng
hcfmusp.relation.referenceNavghare V, 2016, INDIAN J CLIN BIOCHE, V31, P380, DOI 10.1007/s12291-016-0548-yeng
hcfmusp.relation.referenceNoureddin Mazen, 2018, Curr Hepatol Rep, V17, P350, DOI 10.1007/s11901-018-0425-7eng
hcfmusp.relation.referenceOliveira L, 2008, J AGR FOOD CHEM, V56, P9520, DOI 10.1021/jf801709teng
hcfmusp.relation.referenceHernandez VO, 2018, NUTR HOSP, V35, P588, DOI 10.20960/nh.1506eng
hcfmusp.relation.referencePari L, 1999, J ETHNOPHARMACOL, V68, P321, DOI 10.1016/S0378-8741(99)00088-4eng
hcfmusp.relation.referencePerino A, 2021, PHYSIOL REV, V101, P683, DOI 10.1152/physrev.00049.2019eng
hcfmusp.relation.referenceSangsefidi ZS, 2021, PHYTOTHER RES, V35, P5259, DOI 10.1002/ptr.7199eng
hcfmusp.relation.referenceSarma PP, 2021, FOOD FUNCT, V12, P4749, DOI [10.1039/d1fo00477h, 10.1039/D1FO00477H]eng
hcfmusp.relation.referenceSchmittgen TD, 2008, NAT PROTOC, V3, P1101, DOI 10.1038/nprot.2008.73eng
hcfmusp.relation.referenceSimental-Mendia LE, 2021, ADV EXP MED BIOL, V1308, P257, DOI 10.1007/978-3-030-64872-5_18eng
hcfmusp.relation.referenceTessari P, 2009, NUTR METAB CARDIOVAS, V19, P291, DOI 10.1016/j.numecd.2008.12.015eng
hcfmusp.relation.referenceVictorino VJ, 2016, TUMOR BIOL, V37, P6035, DOI 10.1007/s13277-015-4449-0eng
hcfmusp.relation.referenceVijayakumar S, 2008, FITOTERAPIA, V79, P279, DOI 10.1016/j.fitote.2008.01.007eng
hcfmusp.relation.referenceWang R, 2016, EXP THER MED, V11, P1947, DOI 10.3892/etm.2016.3155eng
hcfmusp.relation.referenceWatanabe M, 2006, NATURE, V439, P484, DOI 10.1038/nature04330eng
hcfmusp.relation.referenceWei ML, 2020, EBIOMEDICINE, V55, DOI 10.1016/j.ebiom.2020.102766eng
hcfmusp.relation.referenceXiong Y, 2021, LIFE SCI, V268, DOI 10.1016/j.lfs.2020.119000eng
hcfmusp.relation.referenceYounossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033eng
hcfmusp.relation.referenceZhang CB, 2014, AM J PHYSIOL-ENDOC M, V307, pE305, DOI 10.1152/ajpendo.00034.2014eng
hcfmusp.relation.referenceZhu Y, 2020, NUTR METAB, V17, DOI 10.1186/s12986-020-00473-9eng
dc.description.indexMEDLINEeng
dc.identifier.eissn1099-1573-
hcfmusp.citation.scopus0-
hcfmusp.scopus.lastupdate2022-07-07-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/02
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Artigos e Materiais de Revistas Científicas - LIM/51
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