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Title: COVID-19 in HSCT recipients: a collaborative study of the Brazilian Society of Marrow Transplantation (SBTMO)
Authors: DAUDT, Liane EstevesCORSO, Mariana Cristina MoraesKERBAUY, Mariana NassifASSIS, Luiz Henrique dos Santos deRECHENMACHER, CilianaCOLTURATO, IagoBARBIERI, Fernanda RodriguesROCHA, VandersonMARIANO, LiviaGARCIA, Julia LopesDANTAS, Vanessa Esther Cavalcanti BarretoLOTH, GiseleFUNKE, Vaneuza Araujo MoreiraPELEGRINA, Polliany Roberta DoriniDUARTE, Fernando BarrosoSILVA, Roberto Luiz daARAUJO, Marco Aurelio SalvinoCARLESSE, Fabianne Altruda de Moraes CostaSOUSA, Ana Virginia Lopes deMAIA, Luana AzevedoFERNANDES, Juliana FolloniRODRIGUES, Celso ArraisBONFIM, CarmemMARTINS, Leticia Navarro Gordan FerreiraCIPOLOTTI, RosanaXAVIER, Erick MenezesGOMES, Alessandra AraujoMORALES, Hugo Manuel PazSIMIONI, Anderson J.SOARES, Victor JablonskiMICHALOWSKI, Mariana BohnsHAMERSCHLAK, NelsonMACHADO, Clarisse Martins
Citation: BONE MARROW TRANSPLANTATION, v.57, n.3, p.453-459, 2022
Abstract: In the COVID-19 scenario, patients undergoing hematopoietic stem cell transplantation (HSCT) infected with SARS-CoV-2 may have an increased risk of death. Through a national multicenter study, we aimed to describe the impact of COVID-19 on the survival of HSCT recipients in Brazil. Eighty-six patients with a confirmed diagnosis of SARS-CoV-2 (92% by RT-PCR) were included. There were 24 children and 62 adults receiving an autologous (n = 25) and allogeneic (n = 61) HSCT for malignant (n = 72) and non-malignant (n = 14) disorders. Twenty-six patients died, (10 on autologous (38%) and 16 patients (62%) on allogeneic group). The estimated overall survival (OS) at day 40 was 69%. Adults had decreased OS compared to children (66% vs 79%, p = 0.03). The severity of symptoms at the time of diagnosis, ECOG score, laboratory tests (C-reactive protein, urea values) were higher in patients who died (p < 0.05). In conclusion, HSCT recipients infected with SARS-CoV-2 have a high mortality rate mainly in adults and patients with critical initial COVID-19 presentation. These findings show the fragility of HSCT recipients with SARS-CoV-2 infection. Therefore, the importance of adherence to preventive measures is evident, in addition to prioritizing the vaccination of family members and the HSCT team.
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Artigos e Materiais de Revistas Científicas - COVID-19

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MIP
Departamento de Moléstias Infecciosas e Parasitárias - FM/MIP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/ICr
Instituto da Criança - HC/ICr

Artigos e Materiais de Revistas Científicas - LIM/31
LIM/31 - Laboratório de Genética e Hematologia Molecular

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica

Artigos e Materiais de Revistas Científicas - LIM/52
LIM/52 - Laboratório de Virologia

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