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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorMOURA, Renata Nobre-
dc.contributor.authorKUBOKI, Yeda-
dc.contributor.authorBABA, Elisa Ryoka-
dc.contributor.authorSAFATLE-RIBEIRO, Adriana-
dc.contributor.authorMARTINS, Bruno-
dc.contributor.authorPAULO, Gustavo Andrade de-
dc.contributor.authorTOLENTINO, Luciano Lenz-
dc.contributor.authorLIMA, Marcelo Simas de-
dc.contributor.authorKULCSAR, Marco Aurelio-
dc.contributor.authorSALLUM, Rubens Antonio Aissar-
dc.contributor.authorJR, Ulysses Ribeiro-
dc.contributor.authorMALUF-FILHO, Fauze-
dc.identifier.citationENDOSCOPY INTERNATIONAL OPEN, v.10, n.2, p.E200-E208, 2022-
dc.description.abstractBackground and study aims Patients with head and neck squamous cell carcinoma (HNSCC) are at risk of a second primary tumor in the gastrointestinal tract, most commonly in the esophagus. Screening these patients for esophageal carcinoma may help detect asymptomatic dysplasia and early cancer, thus allowing curative treatment and more prolonged survival, but the impact of endoscopic screening remains uncertain. Here we aimed to describe the long-term results of an esophageal SCC screening program in patients with head and neck cancer in terms of prevalence, associated risk factors, and survival. Patients and methods We performed an observational study of a prospectively collected database including patients with HNSCC who had undergone high-definition endoscopy with chromoscopy between 2010 and 2018 at a Brazilian tertiary academic center. Results The study included 1,888 patients. The esophageal SCC prevalence was 7.9 %, with the majority (77.8 %) being superficial lesions. Significant risk factors for esophageal high-grade dysplasia (HGD) and invasive cancer included tumors of the oral cavity and oropharynx and the presence of low-grade dysplasia (LGD). Overall survival (OS) was significantly shorter among patients in whom esophageal cancer was diagnosed at an advanced stage (P < .001). OS did not significantly differ between patients with HGD and early esophageal cancer versus those without esophageal cancer (P = .210) Conclusions Endoscopic screening for superficial esophageal neoplasia in patients with HNSCC improves esophageal cancer detection. Screening could potentially benefit patients with primary cancer located at the oropharynx or oral cavity. In addition, the detection of esophageal LGD indicates a need for endoscopic surveillance.eng
dc.relation.ispartofEndoscopy International Open-
dc.titleLong-term results of an endoscopic screening program for superficial esophageal cancer in patients with head and neck squamous cell carcinomaeng
dc.rights.holderCopyright GEORG THIEME VERLAG KGeng
dc.subject.wosGastroenterology & Hepatologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Yeda:Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Inst Canc ICESP,Dept Gastroenterol, Sao Paulo, SP, Brazil-
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Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MGT
Departamento de Gastroenterologia - FM/MGT

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/24
LIM/24 - Laboratório de Oncologia Experimental

Artigos e Materiais de Revistas Científicas - LIM/28
LIM/28 - Laboratório de Cirurgia Vascular e da Cabeça e Pescoço

Artigos e Materiais de Revistas Científicas - LIM/37
LIM/37 - Laboratório de Transplante e Cirurgia de Fígado

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