Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/45970
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorFONSECA, Gabriela Rodrigues e-
dc.contributor.authorCORRAL, Marcelo Andreetta-
dc.contributor.authorPAULA, Fabiana Martins de-
dc.contributor.authorMEISEL, Dirce Mary Correia Lima-
dc.contributor.authorGRYSCHEK, Ronaldo Cesar Borges-
dc.contributor.authorLESCANO, Susana Angelica Zevallos-
dc.date.accessioned2022-04-19T12:59:37Z-
dc.date.available2022-04-19T12:59:37Z-
dc.date.issued2022-
dc.identifier.citationREVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.64, article ID e9, 5p, 2022-
dc.identifier.issn0036-4665-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/45970-
dc.description.abstractThe Western-blotting technique was applied to identify antigenic fractions of excretory-secretory Toxocara canis antigen recognized by IgG antibodies throughout an experimental infection in mice challenged by different inocula. Mice were inoculated with 5, 50 and 500 embryonated eggs and serum samples were collected 15, 30, 60, 90 and 120 days post-infection. Serum samples were analyzed using an excretory-secretory Toxocara antigen. Antibodies recognized antigenic fractions from 30 to 90 kDa. The protein fraction of 30-35 kDa was the most frequently recognized regardless of the size of inoculum and the stage of infection represented by the different collection times, but the antigenic recognition was more evident in groups infected with 50 and 500 eggs. This study presents an antigenic panel of the excretory secretory antigen of T. canis and suggests that the 30-35 kDa antigenic fraction is a promising marker of the infection and should be further explored in future studies on experimental toxocariasis.eng
dc.description.sponsorshipFAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/07345-6]-
dc.description.sponsorshipCAPESCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]-
dc.language.isoeng-
dc.publisherINST MEDICINA TROPICAL SAO PAULOeng
dc.relation.ispartofRevista do Instituto de Medicina Tropical de Sao Paulo-
dc.rightsopenAccesseng
dc.subjectBALB/c miceeng
dc.subjectToxocara caniseng
dc.subjectToxocariasiseng
dc.subjectWestern blottingeng
dc.subjectImmunodiagnosiseng
dc.subjectAntigenic fractionseng
dc.subject.otherpotential immunological markerseng
dc.subject.otherwestern blotting procedureeng
dc.subject.otherbalb/c miceeng
dc.subject.otherdiagnosiseng
dc.subject.otherimmunodiagnosiseng
dc.subject.otherlarvaeeng
dc.subject.othercatieng
dc.subject.otheriggeng
dc.titleToxocara canis 30-35 kDa excretory-secretory antigen is an important marker in mice challenged by inocula containing different parasite load levelseng
dc.typearticleeng
dc.rights.holderCopyright INST MEDICINA TROPICAL SAO PAULOeng
dc.identifier.doi10.1590/S1678-9946202264009-
dc.identifier.pmid35137903-
dc.subject.wosInfectious Diseaseseng
dc.subject.wosParasitologyeng
dc.subject.wosTropical Medicineeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.description.articlenumbere9-
hcfmusp.description.volume64-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000754201200005-
hcfmusp.origem.id2-s2.0-85124310804-
hcfmusp.origem.idSCIELO:S0036-46652022000100204-
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1678-9946-
hcfmusp.citation.scopus0-
hcfmusp.scopus.lastupdate2022-09-15-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MIP
Departamento de Moléstias Infecciosas e Parasitárias - FM/MIP

Artigos e Materiais de Revistas Científicas - IMT
Instituto de Medicina Tropical - IMT

Artigos e Materiais de Revistas Científicas - LIM/06
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses


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