Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/46027
Title: Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C
Authors: FINK, Ericka L.ROBERTSON, Courtney L.WAINWRIGHT, Mark S.ROA, Juan D.LOVETT, Marlina E.STULCE, CaseyYACOUB, MaisPOTERA, Renee M.ZIVICK, ElizabethHOLLOWAY, AdrianNAGPAL, AshishWELLNITZ, KariCZECH, TheresaEVEN, Katelyn M.CARVALHO, Werther Brunow deRODRIGUEZ, Isadora SouzaSCHWARTZ, Stephanie P.WALKER, Tracie C.CAMPOS-MINO, SantiagoDERVAN, Leslie A.GENESLAW, Andrew S.SEWELL, Taylor B.PRYCE, PatriceSILVER, Wendy G.LIN, Jieru EgeriaVARGAS, Wendy S.TOPJIAN, AlexisALCAMO, Alicia M.MCGUIRE, Jennifer L.ROJAS, Jesus Angel DominguezMUNOZ, Jaime TasaycoHONG, Sue J.MULLER, William J.DOERFLER, MatthewWILLIAMS, Cydni N.DRURY, KurtBHAGAT, DhristieNELSON, AaronPRICE, DanaDAPUL, HedaSANTOS, LauraKAHOUD, RobertFRANCOEUR, ConallAPPAVU, BrianGUILLIAMS, Kristin P.AGNER, Shannon C.WALSON, Karen H.RASMUSSEN, LindseyJANAS, AnnaFERRAZZANO, PeterFARIAS-MOELLER, RaquelSNOOKS, Kellie C.CHANG, Chung-Chou H.YUN, JamesSCHOBER, Michelle E.
Citation: PEDIATRIC NEUROLOGY, v.128, p.33-44, 2022
Abstract: Background: Our objective was to characterize the frequency, early impact, and risk factors for neuro-logical manifestations in hospitalized children with acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or multisystem inflammatory syndrome in children (MIS-C). Methods: Multicenter, cross-sectional study of neurological manifestations in children aged <18 years hospitalized with positive SARS-CoV-2 test or clinical diagnosis of a SARS-CoV-2-related condition be-tween January 2020 and April 2021. Multivariable logistic regression to identify risk factors for neuro-logical manifestations was performed. Results: Of 1493 children, 1278 (86%) were diagnosed with acute SARS-CoV-2 and 215 (14%) with MIS-C. Overall, 44% of the cohort (40% acute SARS-CoV-2 and 66% MIS-C) had at least one neurological mani-festation. The most common neurological findings in children with acute SARS-CoV-2 and MIS-C diag-nosis were headache (16% and 47%) and acute encephalopathy (15% and 22%), both P < 0.05. Children with neurological manifestations were more likely to require intensive care unit (ICU) care (51% vs 22%), P < 0.001. In multivariable logistic regression, children with neurological manifestations were older (odds ratio [OR] 1.1 and 95% confidence interval [CI] 1.07 to 1.13) and more likely to have MIS-C versus acute SARS-CoV-2 (OR 2.16, 95% CI 1.45 to 3.24), pre-existing neurological and metabolic conditions (OR 3.48, 95% CI 2.37 to 5.15; and OR 1.65, 95% CI 1.04 to 2.66, respectively), and pharyngeal (OR 1.74, 95% CI 1.16 to 2.64) or abdominal pain (OR 1.43, 95% CI 1.03 to 2.00); all P < 0.05. Conclusions: In this multicenter study, 44% of children hospitalized with SARS-CoV-2-related conditions experienced neurological manifestations, which were associated with ICU admission and pre-existing neurological condition. Posthospital assessment for, and support of, functional impairment and neuro-protective strategies are vitally needed.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - COVID-19
COVID-19

Artigos e Materiais de Revistas Científicas - FM/MPE
Departamento de Pediatria - FM/MPE

Artigos e Materiais de Revistas Científicas - LIM/36
LIM/36 - Laboratório de Pediatria Clínica

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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