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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorCHINOCA, J.-
dc.contributor.authorANDRADE, D. S.-
dc.contributor.authorMENDES, A.-
dc.contributor.authorMARCHI, P. De-
dc.contributor.authorPRIETO, T. G.-
dc.contributor.authorBALDAVIRA, C. M.-
dc.contributor.authorFARHAT, C.-
dc.contributor.authorMARTINS, J. R. M.-
dc.contributor.authorNADER, H. B.-
dc.contributor.authorCARRARO, D. M.-
dc.contributor.authorCAPELOZZI, V. L.-
dc.contributor.authorSA, V de-
dc.identifier.citationBRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, v.55, n.1, article ID e11513, 9p, 2022-
dc.description.abstractWe evaluated whether hyaluronan (HA) levels in the sputum could be used as a noninvasive tool to predict progressive disease and treatment response, as detected in a computed tomography scan in non-small cell lung cancer (NSCLC) patients. Sputum samples were collected from 84 patients with histological confirmation of NSCLC, 33 of which were in early-stage and 51 in advanced-stage disease. Patients received systemic chemotherapy (CT) after surgery (n=36), combined CT and immunotherapy (10) (n=15), or targeted therapy for driver mutation and disease relapse (N=4). The primary end-point was to compare sputum HA levels in two different concentrations of hypertonic saline solution with overall survival (OS) and the secondary and exploratory end-points were radiologic responses to treatment and patient outcome. Higher concentrations of HA in the sputum were significantly associated to factors related to tumor stage, phenotype, response to treatment, and outcome. In the early stage, patients with lower sputum HA levels before treatment achieved a complete tumor response after systemic CT with better progression-free survival (PFS) than those with high HA levels. We also examined the importance of the sputum HA concentration and tumor response in the 51 patients who developed metastatic disease and received CT + IO. Patients with low levels of sputum HA showed a complete tumor response in the computed tomography scan and stable disease after CT + IO treatment, as well as a better PFS than those receiving CT alone. HA levels in sputum of NSCLC patients may serve as a candidate biomarker to detect progressive disease and monitor treatment response in computed tomography scans.eng
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/26642-4, 2018/20403-6]-
dc.relation.ispartofBrazilian Journal of Medical and Biological Research-
dc.subjectLung cancereng
dc.subjectRadiologic responseeng
dc.subjectTreatment and outcomeeng
dc.titleMonitoring non-small cell lung cancer progression and treatment response through hyaluronic acid in sputumeng
dc.rights.holderCopyright ASSOC BRAS DIVULG CIENTIFICAeng
dc.subject.wosMedicine, Research & Experimentaleng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, J.:AC Camargo Canc Ctr, Lab Genom & Biol Mol, Sao Paulo, SP, Brazil-, D. S.:AC Camargo Canc Ctr, Lab Genom & Biol Mol, Sao Paulo, SP, Brazil-, A.:Univ Fed Sao Paulo, Dept Bioquim, Escola Paulista Med, Discipline Biol Mol, Sao Paulo, SP, Brazil-, P. De:Hosp Amor Barretos, Dept Oncol Med, Sao Paulo, SP, Brazil-, C.:Univ Sao Paulo, Fac Med, Dept Patol, Sao Paulo, SP, Brazil-, J. R. M.:Univ Fed Sao Paulo, Dept Bioquim, Escola Paulista Med, Discipline Biol Mol, Sao Paulo, SP, Brazil; Univ Fed Sao Paulo, Lab Endocrinol Mol & Translac, Escola Paulista Med, Sao Paulo, SP, Brazil-, H. B.:Univ Fed Sao Paulo, Dept Bioquim, Escola Paulista Med, Discipline Biol Mol, Sao Paulo, SP, Brazil-, D. M.:AC Camargo Canc Ctr, Lab Genom & Biol Mol, Sao Paulo, SP, Brazil-, V de:AC Camargo Canc Ctr, Lab Genom & Biol Mol, Sao Paulo, SP, Brazil; Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, SP, Brazil-
hcfmusp.publisher.cityRIBEIRAO PRETOeng
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Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

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LIM/03 - Laboratório de Medicina Laboratorial

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