Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/46087
Title: B and T Lymphocyte Densities Remain Stable With Age in Human Cortex
Authors: BERRY, KaceyFARIAS-ITAO, Daniela S.GRINBERG, Lea T.PLOWEY, Edward D.SCHNEIDER, Julie A.RODRIGUEZ, Roberta D.SUEMOTO, Claudia K.BUCKWALTER, Marion S.
Citation: ASN NEURO, v.13, article ID 17590914211018117, 11p, 2021
Abstract: One hallmark of human aging is increased brain inflammation represented by glial activation. With age, there is also diminished function of the adaptive immune system, and modest decreases in circulating B- and T-lymphocytes. Lymphocytes traffic through the human brain and reside there in small numbers, but it is unknown how this changes with age. Thus we investigated whether B- and T-lymphocyte numbers change with age in the normal human brain. We examined 16 human subjects in a pilot study and then 40 human subjects from a single brain bank, ranging in age from 44-96 years old, using rigorous criteria for defining neuropathological changes due to age alone. We immunostained post-mortem cortical tissue for B- and T-lymphocytes using antibodies to CD20 and CD3, respectively. We quantified cell density and made a qualitative assessment of cell location in cortical brain sections, and reviewed prior studies. We report that density and location of both B- and T-lymphocytes do not change with age in the normal human cortex. Solitary B-lymphocytes were found equally in intravascular, perivascular, and parenchymal locations, while T-lymphocytes appeared primarily in perivascular clusters. Thus, any change in number or location of lymphocytes in an aging brain may indicate disease rather than normal aging.
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - LIM/22
LIM/22 - Laboratório de Patolologia Cardiovascular

Artigos e Materiais de Revistas Científicas - LIM/66
LIM/66 - Laboratório de Investigação Médica em Envelhecimento


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