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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | BERRY, Kacey | - |
dc.contributor.author | FARIAS-ITAO, Daniela S. | - |
dc.contributor.author | GRINBERG, Lea T. | - |
dc.contributor.author | PLOWEY, Edward D. | - |
dc.contributor.author | SCHNEIDER, Julie A. | - |
dc.contributor.author | RODRIGUEZ, Roberta D. | - |
dc.contributor.author | SUEMOTO, Claudia K. | - |
dc.contributor.author | BUCKWALTER, Marion S. | - |
dc.date.accessioned | 2022-04-19T13:03:57Z | - |
dc.date.available | 2022-04-19T13:03:57Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | ASN NEURO, v.13, article ID 17590914211018117, 11p, 2021 | - |
dc.identifier.issn | 1759-0914 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/46087 | - |
dc.description.abstract | One hallmark of human aging is increased brain inflammation represented by glial activation. With age, there is also diminished function of the adaptive immune system, and modest decreases in circulating B- and T-lymphocytes. Lymphocytes traffic through the human brain and reside there in small numbers, but it is unknown how this changes with age. Thus we investigated whether B- and T-lymphocyte numbers change with age in the normal human brain. We examined 16 human subjects in a pilot study and then 40 human subjects from a single brain bank, ranging in age from 44-96 years old, using rigorous criteria for defining neuropathological changes due to age alone. We immunostained post-mortem cortical tissue for B- and T-lymphocytes using antibodies to CD20 and CD3, respectively. We quantified cell density and made a qualitative assessment of cell location in cortical brain sections, and reviewed prior studies. We report that density and location of both B- and T-lymphocytes do not change with age in the normal human cortex. Solitary B-lymphocytes were found equally in intravascular, perivascular, and parenchymal locations, while T-lymphocytes appeared primarily in perivascular clusters. Thus, any change in number or location of lymphocytes in an aging brain may indicate disease rather than normal aging. | eng |
dc.description.sponsorship | UCSF Summer Explore Fellowship | - |
dc.description.sponsorship | American Heart Association/Allen Initiative in Brain Health and Cognitive Impairment [9PABHI34580007] | - |
dc.description.sponsorship | Leducq Foundation Transatlantic Network of Excellence [Stroke-IMPaCT]Leducq Foundation | - |
dc.description.sponsorship | National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [K24Ag053435] | - |
dc.description.sponsorship | Sao Paulo Research FoundationFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP 2017/24066-1] | - |
dc.description.sponsorship | National Institute of AgingUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01AG017917] | - |
dc.language.iso | eng | - |
dc.publisher | SAGE PUBLICATIONS LTD | eng |
dc.relation.ispartof | Asn Neuro | - |
dc.rights | openAccess | eng |
dc.subject | adaptive immunity | eng |
dc.subject | aging | eng |
dc.subject | brain | eng |
dc.subject | human | eng |
dc.subject | immune | eng |
dc.subject.other | cells | eng |
dc.subject.other | brain | eng |
dc.subject.other | disease | eng |
dc.subject.other | population | eng |
dc.subject.other | community | eng |
dc.subject.other | dementia | eng |
dc.subject.other | subsets | eng |
dc.subject.other | health | eng |
dc.subject.other | memory | eng |
dc.title | B and T Lymphocyte Densities Remain Stable With Age in Human Cortex | eng |
dc.type | article | eng |
dc.rights.holder | Copyright SAGE PUBLICATIONS LTD | eng |
dc.identifier.doi | 10.1177/17590914211018117 | - |
dc.identifier.pmid | 34056948 | - |
dc.subject.wos | Neurosciences | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | BERRY, Kacey:Stanford Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA; Univ Calif San Francisco, Sch Med, Dept Neurol & Pathol, San Francisco, CA USA | - |
hcfmusp.author.external | PLOWEY, Edward D.:Stanford Sch Med, Dept Pathol, Stanford, CA 94305 USA | - |
hcfmusp.author.external | SCHNEIDER, Julie A.:Rush Univ, Dept Pathol, Med Ctr, Chicago, IL USA | - |
hcfmusp.author.external | BUCKWALTER, Marion S.:Stanford Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA; Stanford Sch Med, Dept Neurosurg, Stanford, CA 94305 USA | - |
hcfmusp.description.articlenumber | 17590914211018117 | - |
hcfmusp.description.volume | 13 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000755720600001 | - |
hcfmusp.origem.id | 2-s2.0-85107050833 | - |
hcfmusp.publisher.city | LONDON | eng |
hcfmusp.publisher.country | ENGLAND | eng |
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dc.description.index | MEDLINE | eng |
hcfmusp.citation.scopus | 4 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - LIM/22 Artigos e Materiais de Revistas Científicas - LIM/66 |
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