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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorFARIAS-ITAO, Daniela Souza-
dc.contributor.authorPASQUALUCCI, Carlos Augusto-
dc.contributor.authorANDRADE, Renato Araujo de-
dc.contributor.authorSILVA, Luiz Fernando Ferraz da-
dc.contributor.authorYAHAGI-ESTEVAM, Maristella-
dc.contributor.authorLAGE, Silvia Helena Gelas-
dc.contributor.authorLEITE, Renata Elaine Paraizo-
dc.contributor.authorCAMPO, Alexandre Brincalepe-
dc.contributor.authorSUEMOTO, Claudia Kimie-
dc.identifier.citationJOURNAL OF THE AMERICAN HEART ASSOCIATION, v.11, n.6, article ID e023274, 30p, 2022-
dc.description.abstractBackground Inflammation of the perivascular adipose tissue (PvAT) may be related to atherosclerosis; however, the association of polarized macrophages in the pericoronary PvAT with measurements of atherosclerosis components in humans has not been fully investigated. Methods and Results Coronary arteries were dissected with surrounding PvAT. We evaluated the percentage of arterial obstruction, intima-media thickness, fibrous cap thickness, plaque components, and the number of vasa vasorum. The number of proinflammatory (M1) and anti-inflammatory (M2) macrophages in the periplaque and control PvAT were evaluated using immunohistochemistry. Regression models adjusted for sociodemographic and clinical variables were used. In 319 segments from 82 individuals, we found a correlation of the M1/M2 macrophage density ratio with an increase in arterial obstruction (P=0.02) and lipid content (P=0.01), and a decrease in smooth muscle cells (P=0.02). M1 and the ratio of M1/M2 macrophages were associated with an increased risk of thrombosis (P=0.03). In plaques with thrombosis, M1 macrophages were correlated with a decrease in fibrous cap thickness (P=0.006), an increase in lipid content (P=0.008), and the number of vasa vasorum in the adventitia layer (P=0.001). M2 macrophages were correlated with increased arterial obstruction (P=0.01), calcification (P=0.02), necrosis (P=0.03) only in plaques without thrombosis, and decrease of the number of vasa vasorum in plaques with thrombosis (P=0.003). Conclusions M1 macrophages in the periplaque PvAT were associated with a higher risk of coronary thrombosis and were correlated with histological components of plaque progression and destabilization. M2 macrophages were correlated with plaque size, calcification, necrotic content, and a decrease in the number of vasa vasorum in the adventitia layer.eng
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/00335-2, 2017/11313-0]-
dc.description.sponsorshipFAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/12290-3, 2017/24066-1]-
dc.relation.ispartofJournal of the American Heart Association-
dc.subjectcoronary artery diseaseeng
dc.subjectpericoronary adipose tissueeng
dc.subject.otherepicardial adipose-tissueeng
dc.titleMacrophage Polarization in the Perivascular Fat Was Associated With Coronary Atherosclerosiseng
dc.rights.holderCopyright WILEYeng
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Renato Araujo de:Fed Inst Educ Sci & Technol Sao Paulo, Control & Automat Engn, Sao Paulo, Brazil-, Alexandre Brincalepe:Fed Inst Educ Sci & Technol Sao Paulo, Control & Automat Engn, Sao Paulo, Brazil-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/05
LIM/05 - Laboratório de Poluição Atmosférica Experimental

Artigos e Materiais de Revistas Científicas - LIM/22
LIM/22 - Laboratório de Patolologia Cardiovascular

Artigos e Materiais de Revistas Científicas - LIM/66
LIM/66 - Laboratório de Investigação Médica em Envelhecimento

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