Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/46096
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorFARIAS-ITAO, Daniela Souza-
dc.contributor.authorPASQUALUCCI, Carlos Augusto-
dc.contributor.authorANDRADE, Renato Araujo de-
dc.contributor.authorSILVA, Luiz Fernando Ferraz da-
dc.contributor.authorYAHAGI-ESTEVAM, Maristella-
dc.contributor.authorLAGE, Silvia Helena Gelas-
dc.contributor.authorLEITE, Renata Elaine Paraizo-
dc.contributor.authorCAMPO, Alexandre Brincalepe-
dc.contributor.authorSUEMOTO, Claudia Kimie-
dc.date.accessioned2022-04-19T13:03:59Z-
dc.date.available2022-04-19T13:03:59Z-
dc.date.issued2022-
dc.identifier.citationJOURNAL OF THE AMERICAN HEART ASSOCIATION, v.11, n.6, article ID e023274, 30p, 2022-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/46096-
dc.description.abstractBackground Inflammation of the perivascular adipose tissue (PvAT) may be related to atherosclerosis; however, the association of polarized macrophages in the pericoronary PvAT with measurements of atherosclerosis components in humans has not been fully investigated. Methods and Results Coronary arteries were dissected with surrounding PvAT. We evaluated the percentage of arterial obstruction, intima-media thickness, fibrous cap thickness, plaque components, and the number of vasa vasorum. The number of proinflammatory (M1) and anti-inflammatory (M2) macrophages in the periplaque and control PvAT were evaluated using immunohistochemistry. Regression models adjusted for sociodemographic and clinical variables were used. In 319 segments from 82 individuals, we found a correlation of the M1/M2 macrophage density ratio with an increase in arterial obstruction (P=0.02) and lipid content (P=0.01), and a decrease in smooth muscle cells (P=0.02). M1 and the ratio of M1/M2 macrophages were associated with an increased risk of thrombosis (P=0.03). In plaques with thrombosis, M1 macrophages were correlated with a decrease in fibrous cap thickness (P=0.006), an increase in lipid content (P=0.008), and the number of vasa vasorum in the adventitia layer (P=0.001). M2 macrophages were correlated with increased arterial obstruction (P=0.01), calcification (P=0.02), necrosis (P=0.03) only in plaques without thrombosis, and decrease of the number of vasa vasorum in plaques with thrombosis (P=0.003). Conclusions M1 macrophages in the periplaque PvAT were associated with a higher risk of coronary thrombosis and were correlated with histological components of plaque progression and destabilization. M2 macrophages were correlated with plaque size, calcification, necrotic content, and a decrease in the number of vasa vasorum in the adventitia layer.eng
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/00335-2, 2017/11313-0]-
dc.description.sponsorshipFAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/12290-3, 2017/24066-1]-
dc.language.isoeng-
dc.publisherWILEYeng
dc.relation.ispartofJournal of the American Heart Association-
dc.rightsopenAccesseng
dc.subjectatherosclerosiseng
dc.subjectcoronary artery diseaseeng
dc.subjectinflammationeng
dc.subjectmacrophageseng
dc.subjectpericoronary adipose tissueeng
dc.subject.otherepicardial adipose-tissueeng
dc.subject.otherinflammationeng
dc.subject.othercalcificationeng
dc.subject.otherphenotypeeng
dc.subject.otherdiseaseeng
dc.titleMacrophage Polarization in the Perivascular Fat Was Associated With Coronary Atherosclerosiseng
dc.typearticleeng
dc.rights.holderCopyright WILEYeng
dc.identifier.doi10.1161/JAHA.121.023274-
dc.identifier.pmid35229617-
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalANDRADE, Renato Araujo de:Fed Inst Educ Sci & Technol Sao Paulo, Control & Automat Engn, Sao Paulo, Brazil-
hcfmusp.author.externalCAMPO, Alexandre Brincalepe:Fed Inst Educ Sci & Technol Sao Paulo, Control & Automat Engn, Sao Paulo, Brazil-
hcfmusp.description.articlenumbere023274-
hcfmusp.description.issue6-
hcfmusp.description.volume11-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000769036300039-
hcfmusp.origem.id2-s2.0-85126830542-
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAndrade RA., 2017, PROCESSAMENTO IMAGENeng
hcfmusp.relation.referenceChatterjee TK, 2009, CIRC RES, V104, P541, DOI 10.1161/CIRCRESAHA.108.182998eng
hcfmusp.relation.referenceCho KY, 2013, J STROKE CEREBROVASC, V22, P910, DOI 10.1016/j.jstrokecerebrovasdis.2012.11.020eng
hcfmusp.relation.referenceColin S, 2014, IMMUNOL REV, V262, P153, DOI 10.1111/imr.12218eng
hcfmusp.relation.referenceFarfel JM, 2013, NEUROLOGY, V81, P650, DOI 10.1212/WNL.0b013e3182a08f1beng
hcfmusp.relation.referenceFarias-Itao DS, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.013793eng
hcfmusp.relation.referenceFarias-Itao DS, 2016, JMIR RES PROTOC, V5, DOI 10.2196/resprot.6340eng
hcfmusp.relation.referenceFernandez-Friera L, 2019, J AM COLL CARDIOL, V73, P1371, DOI 10.1016/j.jacc.2018.12.075eng
hcfmusp.relation.referenceFerretti Renata Eloah de Lucena, 2010, Dement. neuropsychol., V4, P138, DOI 10.1590/S1980-57642010DN40200011eng
hcfmusp.relation.referenceFitzgibbons TP, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.124859eng
hcfmusp.relation.referenceGo AS, 2013, CIRCULATION, V127, pE6, DOI 10.1161/CIR.0b013e31828124adeng
hcfmusp.relation.referenceGurses KM, 2017, J CARDIOL, V69, P851, DOI 10.1016/j.jjcc.2016.08.016eng
hcfmusp.relation.referenceHarris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010eng
hcfmusp.relation.referenceHedgire S, 2018, RADIOLOGY, V287, P808, DOI 10.1148/radiol.2017171568eng
hcfmusp.relation.referenceHirata Y, 2011, J AM COLL CARDIOL, V58, P248, DOI 10.1016/j.jacc.2011.01.048eng
hcfmusp.relation.referenceIto H, 2020, CIRC J, V84, P769, DOI 10.1253/circj.CJ-19-0914eng
hcfmusp.relation.referenceKanaji Y, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.120.016504eng
hcfmusp.relation.referenceKhallou-Laschet J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008852eng
hcfmusp.relation.referenceKitagawa T, 2015, ATHEROSCLEROSIS, V243, P293, DOI 10.1016/j.atherosclerosis.2015.09.013eng
hcfmusp.relation.referenceKonishi M, 2010, ATHEROSCLEROSIS, V213, P649, DOI 10.1016/j.atherosclerosis.2010.10.007eng
hcfmusp.relation.referenceKroll L, 2021, J CLIN MED, V10, DOI 10.3390/jcm10020356eng
hcfmusp.relation.referenceLibby P, 2015, CIRC RES, V116, P307, DOI 10.1161/CIRCRESAHA.116.301313eng
hcfmusp.relation.referenceLumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881eng
hcfmusp.relation.referenceMargaritis M, 2013, CIRCULATION, V127, P2209, DOI 10.1161/CIRCULATIONAHA.112.001133eng
hcfmusp.relation.referenceMcClain J, 2013, OBESITY, V21, P1056, DOI 10.1002/oby.20090eng
hcfmusp.relation.referenceMcKenney-Drake ML, 2017, ANN THORAC SURG, V103, P1622, DOI 10.1016/j.athoracsur.2016.11.034eng
hcfmusp.relation.referenceMikami T, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.018905eng
hcfmusp.relation.referenceMontanaro M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010395eng
hcfmusp.relation.referenceNAKATANI S, 1995, CIRCULATION, V91, P2904, DOI 10.1161/01.CIR.91.12.2904eng
hcfmusp.relation.referenceNarula J, 2013, J AM COLL CARDIOL, V61, P1041, DOI 10.1016/j.jacc.2012.10.054eng
hcfmusp.relation.referenceNumaguchi R, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.011147eng
hcfmusp.relation.referenceOhman MK, 2011, ATHEROSCLEROSIS, V219, P33, DOI 10.1016/j.atherosclerosis.2011.07.012eng
hcfmusp.relation.referenceOhyama K, 2018, J AM COLL CARDIOL, V71, P414, DOI 10.1016/j.jacc.2017.11.046eng
hcfmusp.relation.referenceOikonomou EK, 2018, LANCET, V392, P929, DOI 10.1016/S0140-6736(18)31114-0eng
hcfmusp.relation.referencePierzynova A, 2019, NUTR METAB CARDIOVAS, V29, P946, DOI 10.1016/j.numecd.2019.05.063eng
hcfmusp.relation.referenceRidker PM, 2017, NEW ENGL J MED, V377, P1119, DOI 10.1056/NEJMoa1707914eng
hcfmusp.relation.referenceShimabukuro M, 2013, ARTERIOSCL THROM VAS, V33, P1077, DOI 10.1161/ATVBAHA.112.300829eng
hcfmusp.relation.referenceShioi A, 2018, J ATHEROSCLER THROMB, V25, P294, DOI 10.5551/jat.RV17020eng
hcfmusp.relation.referenceSkiba DS, 2017, BRIT J PHARMACOL, V174, P4055, DOI 10.1111/bph.13685eng
hcfmusp.relation.referenceSuemoto CK, 2017, PLOS MED, V14, DOI 10.1371/journal.pmed.1002267eng
hcfmusp.relation.referenceSuemoto CK, 2011, STROKE, V42, P3614, DOI 10.1161/STROKEAHA.111.628156eng
hcfmusp.relation.referenceTakaoka M, 2010, ARTERIOSCL THROM VAS, V30, P1576, DOI 10.1161/ATVBAHA.110.207175eng
hcfmusp.relation.referenceTanaka K, 2011, ATHEROSCLEROSIS, V215, P366, DOI 10.1016/j.atherosclerosis.2011.01.016eng
hcfmusp.relation.referenceTardif JC, 2019, NEW ENGL J MED, V381, P2497, DOI 10.1056/NEJMoa1912388eng
hcfmusp.relation.referenceUiversity of California Los Angeles: Institute for Digital Research & Education, REGR STAT CHAPT 4 OLeng
hcfmusp.relation.referenceUniversity of California Los Angeles: Statistical Consulting Group., CAN US COUNTF CHOOSeng
hcfmusp.relation.referenceVerhagen SN, 2014, ATHEROSCLEROSIS, V233, P242, DOI 10.1016/j.atherosclerosis.2013.12.005eng
hcfmusp.relation.referenceVeseli BE, 2017, EUR J PHARMACOL, V816, P3, DOI 10.1016/j.ejphar.2017.05.010eng
hcfmusp.relation.referenceWorld Health Organization, 2021, CARD DIS CVDSeng
hcfmusp.relation.referenceYahagi K, 2016, NAT REV CARDIOL, V13, P79, DOI 10.1038/nrcardio.2015.164eng
dc.description.indexMEDLINEeng
dc.identifier.eissn2047-9980-
hcfmusp.citation.scopus1-
hcfmusp.scopus.lastupdate2022-08-11-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/05
LIM/05 - Laboratório de Poluição Atmosférica Experimental

Artigos e Materiais de Revistas Científicas - LIM/22
LIM/22 - Laboratório de Patolologia Cardiovascular

Artigos e Materiais de Revistas Científicas - LIM/66
LIM/66 - Laboratório de Investigação Médica em Envelhecimento


Files in This Item:
File Description SizeFormat 
art_FARIAS-ITAO_Macrophage_Polarization_in_the_Perivascular_Fat_Was_Associated_2022.PDFpublishedVersion (English)2.83 MBAdobe PDFThumbnail
View/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.