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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorCHATKIN, Jose-
dc.contributor.authorCORREA, Liana-
dc.contributor.authorSANTOS, Ubiratan-
dc.identifier.citationCLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, v.62, n.1, Special Issue, p.72-89, 2022-
dc.description.abstractAir pollution is a worrisome risk factor for global morbidity and mortality and plays a special role in many respiratory conditions. It contributes to around 8 million deaths/year, with outdoor exposure being responsible for more than 4.2 million deaths throughout the world, while more than 3.8 million die from situations related to indoor pollution. Pollutant agents induce several respiratory symptoms. In addition, there is a clear interference in numerous asthma outcomes, such as incidence, prevalence, hospital admission, visits to emergency departments, mortality, and asthma attacks, among others. The particulate matter group of pollutants includes coarse particles/PM10, fine particles/PM2.5, and ultrafine particles/PM0.1. The gaseous components include ground-level ozone, nitrogen dioxide, sulfur dioxide, and carbon monoxide. The timing, load, and route of allergen exposure are other items affecting allergic disease phenotypes. The complex interaction between pollutant exposures and human host factors has an implication in the development and rise of asthma as a public health problem. However, there are hiatuses in the understanding of the pathways in this disease. The routes through which pollutants induce asthma are multiple, and include the epigenetic changes that occur in the respiratory tract microbiome, oxidative stress, and immune dysregulation. In addition, the expansion of the modern Westernized lifestyle, which is characterized by intense urbanization and more time spent indoors, resulted in greater exposure to polluted air. Another point to consider is the different role of the environment according to age groups. Children growing up in economically disadvantaged neighborhoods suffer more important negative health impacts. This narrative review highlights the principal polluting agents, their sources of emission, epidemiological findings, and mechanistic evidence that links environmental exposures to asthma.eng
dc.publisherHUMANA PRESS INCeng
dc.relation.ispartofClinical Reviews in Allergy & Immunology-
dc.subjectAir pollutioneng
dc.subjectParticulate mattereng
dc.subject.otheroutdoor air-pollutioneng
dc.subject.othershort-term exposureeng
dc.subject.otherambient ultrafine particleseng
dc.subject.otheradult-onset asthmaeng
dc.subject.otherrespiratory healtheng
dc.subject.otherchildhood asthmaeng
dc.subject.othernoncommunicable diseaseseng
dc.subject.otherhospital admissionseng
dc.subject.otherparticulate mattereng
dc.titleExternal Environmental Pollution as a Risk Factor for Asthmaeng
dc.rights.holderCopyright HUMANA PRESS INCeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Jose:Pontifical Catholic Univ Rio Grande Do Sul PUCRS, Hosp Sao Lucas PUCRS, Pulmonol Div, Sch Med, Porto Alegre, RS, Brazil-, Liana:Pontifical Catholic Univ Rio Grande Do Sul PUCRS, Hosp Sao Lucas PUCRS, Hlth Sci Doctorate Program, Sch Med, Porto Alegre, RS, Brazil-
hcfmusp.description.issueSpecial Issue-
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Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/09
LIM/09 - Laboratório de Pneumologia

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

Artigos e Materiais de Revistas Científicas - ODS/11
ODS/11 - Cidades e comunidades sustentáveis

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