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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorTENORIO, Jefferson Rocha-
dc.contributor.authorDUARTE, Nathalia Tuany-
dc.contributor.authorANDRADE, Natalia Silva-
dc.contributor.authorBERGAMINI, Mariana Lobo-
dc.contributor.authorMAMANA, Ana Carolina-
dc.contributor.authorBRAZ-SILVA, Paulo Henrique-
dc.contributor.authorORTEGA, Karem L.-
dc.identifier.citationCLINICAL ORAL INVESTIGATIONS, v.26, n.2, p.1861-1868, 2022-
dc.description.abstractObjective To assess the serum and salivary levels of biomarkers related to bone metabolism in cirrhotic patients as well as the evidence of osteoporotic changes on panoramic radiographs. Materials and methods Thirty-eight cirrhotic patients underwent anamnesis and physical examination. Specimens of blood and saliva were collected for evaluation by using Luminex (TM) xMAP technology to quantify RANKL, OPG, IL-1 beta, IL-6 and TNF-alpha. Panoramic radiographs were evaluated based on the mandibular cortical index (MCI) and the resulting data were compared to the expression of biomarkers in serum and saliva. Descriptive data analysis was performed and the Mann-Whitney's test and Spearman's correlation were used. Results Most of the sample consisted of males (68.4%) who had cirrhosis mostly resulting from alcoholism (28.9%). Median concentration values of RANKL (74.44 pg/mL), IL-1 beta (45.91 pg/mL), IL-6 (67.69 pg/mL) and TNF-alpha (5.97 pg/mL) in saliva were higher than those observed in serum. In 72.7% of the panoramic radiographs, MCI was found to be suggestive of osteoporotic changes. No statistically significant correlation was observed between salivary and serum expressions of biomarkers or between biomarkers and MCI. Conclusion RANKL, OPG, IL-1 beta, IL-6 and TNF-alpha are expressed differently in serum and saliva and the concentration of these biomarkers is not related to MCI.eng
dc.description.sponsorshipBrazilian National Council for Scientific and Technological Development (CNPq grant)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)Fundacao de Apoio a Pesquisa do Distrito Federal (FAPDF) [44004/2014-5]-
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP grant)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/07727]-
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (CAPES)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]-
dc.relation.ispartofClinical Oral Investigations-
dc.subjectHepatic cirrhosiseng
dc.subjectBone biomarkerseng
dc.subjectPanoramic radiographyeng
dc.subject.otherpanoramic radiographic findingseng
dc.subject.otherbiochemical markerseng
dc.subject.otherimmune dysfunctioneng
dc.subject.othermineral densityeng
dc.titleAssessment of bone metabolism biomarkers in serum and saliva of cirrhotic patientseng
dc.rights.holderCopyright SPRINGER HEIDELBERGeng
dc.subject.wosDentistry, Oral Surgery & Medicineeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Jefferson Rocha:Univ Sao Paulo, Sch Dent, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508900 Sao Paulo, SP, Brazil-, Nathalia Tuany:Univ Sao Paulo, Sch Dent, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508900 Sao Paulo, SP, Brazil-, Natalia Silva:Univ Sao Paulo, Sch Dent, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508900 Sao Paulo, SP, Brazil; Univ Fed Sergipe, Dept Dent, Lagarto, Sergipe, Brazil-, Mariana Lobo:Univ Sao Paulo, Sch Dent, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508900 Sao Paulo, SP, Brazil-, Karem L.:Univ Sao Paulo, Sch Dent, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508900 Sao Paulo, SP, Brazil-
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Artigos e Materiais de Revistas Científicas - FM/MIP
Departamento de Moléstias Infecciosas e Parasitárias - FM/MIP

Artigos e Materiais de Revistas Científicas - LIM/52
LIM/52 - Laboratório de Virologia

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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