Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorSAPKOTA, Dipak-
dc.contributor.authorSHARMA, Sunita-
dc.contributor.authorSOLAND, Tine M.-
dc.contributor.authorBRAZ-SILVA, Paulo H.-
dc.contributor.authorTEH, Muy-Teck-
dc.identifier.citationCLINICAL AND EXPERIMENTAL DENTAL RESEARCH, v.8, n.1, p.117-122, 2022-
dc.description.abstractObjective: Besides angiotensin converting enzyme 2 (ACE2), an active involvement of proteases (FURIN and/or TMPRSS2) is important for cellular entry of SARS-CoV-2. Therefore, a simultaneous expression profiling of entry proteins in a tissue might provide a better risk assessment of SARS-CoV-2 infection as compared to individual proteins. In an attempt to understand the relative susceptibility of oral squamous cell carcinoma (OSCC) lesions as compared to the normal oral mucosa (NOM) for SARS-CoV-2 attachment/entry, this study examined the mRNA and protein expression profiles of ACE2, FURIN, and TMPRSS2 in the corresponding tissues using public transcriptomic and proteomics datasets. Methods and methods: Public transcriptomic and proteomics datasets (the Cancer Genome Atlas (TCGA)/the Genotype-Tissue Expression (GTEx), the Human Protein Atlas (HPA), and two independent microarray datasets) were used to examine the expression profiles of ACE2, TMPRSS2 and FURIN in NOM and OSCC. Results: ACE2, TMPRSS2, and FURIN mRNAs were detected in NOM, however, at lower levels as compared to other body tissues. Except for moderate up-regulation of FURIN, expression levels of ACE2 and TMPRSS2 mRNA were unchanged/downregulated in OSCC as compared to the NOM. Conclusions: These results indicate that NOM may serve as a possible site for SARS-CoV-2 attachment, however, to a lesser extent as compared to organs with higher expression levels of the SARS-CoV-2 entry proteins. However, the evidence is lacking to suggest that expression status of entry proteins predisposes OSCC lesions to additional risk for SARS-CoV-2 attachment/entry as compared to NOM.eng
dc.description.sponsorshipFaculty of Dentistry, University of Oslo-
dc.relation.ispartofClinical and Experimental Dental Research-
dc.subjecthead cancereng
dc.subjectneck cancereng
dc.subjectoral cancereng
dc.titleExpression profile of SARS-CoV-2 cellular entry proteins in normal oral mucosa and oral squamous cell carcinomaeng
dc.rights.holderCopyright WILEYeng
dc.subject.wosDentistry, Oral Surgery & Medicineeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Dipak:Univ Oslo, Fac Dent, Dept Oral Biol, Oslo, Norway-, Sunita:Univ Oslo, Fac Dent, Dept Oral Biol, Oslo, Norway-, Tine M.:Univ Oslo, Fac Dent, Dept Oral Biol, Oslo, Norway; Oslo Univ Hosp, Rigshosp, Dept Pathol, Oslo, Norway-, Muy-Teck:Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Ctr Oral Immunobiol & Regenerat Med, London, England; Guizhou Med Univ, Affiliated Stomatol Hosp, China British Joint Mol Head & Neck Canc Res Lab, Guiyang, Peoples R China-
hcfmusp.relation.referenceAran D, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01027-zeng
hcfmusp.relation.referenceArdlie KG, 2015, SCIENCE, V348, P648, DOI 10.1126/science.1262110eng
hcfmusp.relation.referenceChauhan A, 2020, MED HYPOTHESES, V144, DOI 10.1016/j.mehy.2020.109987eng
hcfmusp.relation.referenceChen C, 2008, CANCER EPIDEM BIOMAR, V17, P2152, DOI 10.1158/1055-9965.EPI-07-2893eng
hcfmusp.relation.referencede Cicco RL, 2004, CLIN CANCER RES, V10, P4480, DOI 10.1158/1078-0432.CCR-03-0670eng
hcfmusp.relation.referenceForrest ARR, 2014, NATURE, V507, P462, DOI 10.1038/nature13182eng
hcfmusp.relation.referenceHamming I, 2004, J PATHOL, V203, P631, DOI 10.1002/path.1570eng
hcfmusp.relation.referenceHoffmann M, 2020, CELL, V181, P271, DOI 10.1016/j.cell.2020.02.052eng
hcfmusp.relation.referenceHoffmann M, 2020, MOL CELL, V78, P779, DOI 10.1016/j.molcel.2020.04.022eng
hcfmusp.relation.referenceKong Q, 2020, MOL CANCER, V19, DOI 10.1186/s12943-020-01209-2eng
hcfmusp.relation.referenceLee LYW, 2020, LANCET, V395, P1919, DOI 10.1016/S0140-6736(20)31173-9eng
hcfmusp.relation.referencePascolo L, 2020, J DENT RES, V99, P1120, DOI 10.1177/0022034520933589eng
hcfmusp.relation.referencePerlman S, 2009, NAT REV MICROBIOL, V7, P439, DOI 10.1038/nrmicro2147eng
hcfmusp.relation.referenceRentoft M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035276eng
hcfmusp.relation.referenceShang J, 2020, P NATL ACAD SCI USA, V117, P11727, DOI 10.1073/pnas.2003138117eng
hcfmusp.relation.referenceTang ZF, 2017, NUCLEIC ACIDS RES, V45, pW98, DOI 10.1093/nar/gkx247eng
hcfmusp.relation.referenceTian JB, 2020, LANCET ONCOL, V21, P893, DOI 10.1016/S1470-2045(20)30309-0eng
hcfmusp.relation.referenceUhlen M, 2015, SCIENCE, V347, DOI 10.1126/science.1260419eng
hcfmusp.relation.referenceXu H, 2020, INT J ORAL SCI, V12, DOI [10.1038/s41368-020-0074-X, 10.1038/s41368-020-0074-x]eng
hcfmusp.relation.referenceYu J, 2020, JAMA ONCOL, V6, P1108, DOI 10.1001/jamaoncol.2020.0980eng
hcfmusp.relation.referenceZHOU P, 2020, NATURE 0203, pNIL1, DOI 10.1038/s41586-020-2012-7eng
hcfmusp.relation.referenceZou X, 2020, FRONT MED-PRC, V14, P185, DOI 10.1007/s11684-020-0754-0eng
Appears in Collections:

Artigos e Materiais de Revistas Científicas - COVID-19

Artigos e Materiais de Revistas Científicas - LIM/52
LIM/52 - Laboratório de Virologia

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

Artigos e Materiais de Revistas Científicas - ODS/10
ODS/10 - Redução da desigualdade

Files in This Item:
File Description SizeFormat 
art_SAPKOTA_Expression_profile_of_SARSCoV2_cellular_entry_proteins_in_2022.PDFpublishedVersion (English)469.1 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.