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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorSILVA, Aderbal R. T.-
dc.contributor.authorGRINBERG, Lea T.-
dc.contributor.authorFARFEL, Jose M.-
dc.contributor.authorDINIZ, Breno S.-
dc.contributor.authorLIMA, Leandro A.-
dc.contributor.authorSILVA, Paulo J. S.-
dc.contributor.authorFERRETTI, Renata E. L.-
dc.contributor.authorROCHA, Rafael M.-
dc.contributor.authorJACOB FILHO, Wilson-
dc.contributor.authorCARRARO, Dirce M.-
dc.contributor.authorBRENTANI, Helena-
dc.date.accessioned2013-07-30T14:41:51Z-
dc.date.available2013-07-30T14:41:51Z-
dc.date.issued2012-
dc.identifier.citationPLOS ONE, v.7, n.11, article ID e48751, 11p, 2012-
dc.identifier.issn1932-6203-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/468-
dc.description.abstractAlzheimer's disease (AD) is the most common cause of dementia in the human population, characterized by a spectrum of neuropathological abnormalities that results in memory impairment and loss of other cognitive processes as well as the presence of non-cognitive symptoms. Transcriptomic analyses provide an important approach to elucidating the pathogenesis of complex diseases like AD, helping to figure out both pre-clinical markers to identify susceptible patients and the early pathogenic mechanisms to serve as therapeutic targets. This study provides the gene expression profile of postmortem brain tissue from subjects with clinic-pathological AD (Braak IV, V, or V and CERAD B or C; and CDR >= 1), preclinical AD (Braak IV, V, or VI and CERAD B or C; and CDR = 0), and healthy older individuals (Braak <= II and CERAD 0 or A; and CDR = 0) in order to establish genes related to both AD neuropathology and clinical emergence of dementia. Based on differential gene expression, hierarchical clustering and network analysis, genes involved in energy metabolism, oxidative stress, DNA damage/repair, senescence, and transcriptional regulation were implicated with the neuropathology of AD; a transcriptional profile related to clinical manifestation of AD could not be detected with reliability using differential gene expression analysis, although genes involved in synaptic plasticity, and cell cycle seems to have a role revealed by gene classifier. In conclusion, the present data suggest gene expression profile changes secondary to the development of AD-related pathology and some genes that appear to be related to the clinical manifestation of dementia in subjects with significant AD pathology, making necessary further investigations to better understand these transcriptional findings on the pathogenesis and clinical emergence of AD.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2005/04151-7]-
dc.language.isoeng-
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.relation.ispartofPlos One-
dc.rightsopenAccess-
dc.subject.othermild cognitive impairment-
dc.subject.othermolecular interaction database-
dc.subject.othergene-expression-
dc.subject.otheramyloid deposition-
dc.subject.othernondemented individuals-
dc.subject.otherup-regulation-
dc.subject.otherdna-damage-
dc.subject.otherprotein-
dc.subject.otherbrain-
dc.subject.othermicroarray-
dc.titleTranscriptional Alterations Related to Neuropathology and Clinical Manifestation of Alzheimer's Disease-
dc.typearticle-
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE-
dc.identifier.doi10.1371/journal.pone.0048751-
dc.identifier.pmid23144955-
dc.subject.wosMultidisciplinary Sciences-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalSILVA, Aderbal R. T.:AC Camargo Hosp, Res Ctr CIPE, Sao Paulo, Brazil; Brazilian Brain Bank, Aging Brain Study Grp, LIM 22, Sao Paulo, Brazil-
hcfmusp.author.externalLIMA, Leandro A.:AC Camargo Hosp, Res Ctr CIPE, Sao Paulo, Brazil-
hcfmusp.author.externalSILVA, Paulo J. S.:Univ Sao Paulo, Dept Comp Sci, Inst Math & Stat, Sao Paulo, Brazil-
hcfmusp.author.externalROCHA, Rafael M.:AC Camargo Hosp, Res Ctr CIPE, Sao Paulo, Brazil-
hcfmusp.author.externalCARRARO, Dirce M.:AC Camargo Hosp, Res Ctr CIPE, Sao Paulo, Brazil-
hcfmusp.description.articlenumbere48751-
hcfmusp.description.issue11-
hcfmusp.description.volume7-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84868680722-
hcfmusp.origem.idWOS:000311935800120-
hcfmusp.publisher.citySAN FRANCISCO-
hcfmusp.publisher.countryUSA-
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dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipFAPESP-
hcfmusp.lim.ref2012-
hcfmusp.citation.scopus25-
hcfmusp.scopus.lastupdate2022-05-20-
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