Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorSILVA, Aderbal R. T.-
dc.contributor.authorGRINBERG, Lea T.-
dc.contributor.authorFARFEL, Jose M.-
dc.contributor.authorDINIZ, Breno S.-
dc.contributor.authorLIMA, Leandro A.-
dc.contributor.authorSILVA, Paulo J. S.-
dc.contributor.authorFERRETTI, Renata E. L.-
dc.contributor.authorROCHA, Rafael M.-
dc.contributor.authorJACOB FILHO, Wilson-
dc.contributor.authorCARRARO, Dirce M.-
dc.contributor.authorBRENTANI, Helena-
dc.identifier.citationPLOS ONE, v.7, n.11, article ID e48751, 11p, 2012-
dc.description.abstractAlzheimer's disease (AD) is the most common cause of dementia in the human population, characterized by a spectrum of neuropathological abnormalities that results in memory impairment and loss of other cognitive processes as well as the presence of non-cognitive symptoms. Transcriptomic analyses provide an important approach to elucidating the pathogenesis of complex diseases like AD, helping to figure out both pre-clinical markers to identify susceptible patients and the early pathogenic mechanisms to serve as therapeutic targets. This study provides the gene expression profile of postmortem brain tissue from subjects with clinic-pathological AD (Braak IV, V, or V and CERAD B or C; and CDR >= 1), preclinical AD (Braak IV, V, or VI and CERAD B or C; and CDR = 0), and healthy older individuals (Braak <= II and CERAD 0 or A; and CDR = 0) in order to establish genes related to both AD neuropathology and clinical emergence of dementia. Based on differential gene expression, hierarchical clustering and network analysis, genes involved in energy metabolism, oxidative stress, DNA damage/repair, senescence, and transcriptional regulation were implicated with the neuropathology of AD; a transcriptional profile related to clinical manifestation of AD could not be detected with reliability using differential gene expression analysis, although genes involved in synaptic plasticity, and cell cycle seems to have a role revealed by gene classifier. In conclusion, the present data suggest gene expression profile changes secondary to the development of AD-related pathology and some genes that appear to be related to the clinical manifestation of dementia in subjects with significant AD pathology, making necessary further investigations to better understand these transcriptional findings on the pathogenesis and clinical emergence of AD.-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2005/04151-7]-
dc.relation.ispartofPlos One-
dc.subject.othermild cognitive impairment-
dc.subject.othermolecular interaction database-
dc.subject.otheramyloid deposition-
dc.subject.othernondemented individuals-
dc.titleTranscriptional Alterations Related to Neuropathology and Clinical Manifestation of Alzheimer's Disease-
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE-
dc.subject.wosMultidisciplinary Sciences-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Aderbal R. T.:AC Camargo Hosp, Res Ctr CIPE, Sao Paulo, Brazil; Brazilian Brain Bank, Aging Brain Study Grp, LIM 22, Sao Paulo, Brazil-, Leandro A.:AC Camargo Hosp, Res Ctr CIPE, Sao Paulo, Brazil-, Paulo J. S.:Univ Sao Paulo, Dept Comp Sci, Inst Math & Stat, Sao Paulo, Brazil-, Rafael M.:AC Camargo Hosp, Res Ctr CIPE, Sao Paulo, Brazil-, Dirce M.:AC Camargo Hosp, Res Ctr CIPE, Sao Paulo, Brazil-
hcfmusp.publisher.citySAN FRANCISCO-
hcfmusp.relation.referenceAbdul HM, 2006, J NEUROCHEM, V96, P1322, DOI 10.1111/j.1471-4159.2005.03647.x-
hcfmusp.relation.referenceAizenstein HJ, 2008, ARCH NEUROL-CHICAGO, V65, P1509, DOI 10.1001/archneur.65.11.1509-
hcfmusp.relation.referenceBlalock EM, 2004, P NATL ACAD SCI USA, V101, P2173, DOI 10.1073/pnas.0308512100-
hcfmusp.relation.referenceBlennow K, 2006, LANCET, V368, P387, DOI 10.1016/S0140-6736(06)69113-7-
hcfmusp.relation.referenceBRAAK H, 1991, ACTA NEUROPATHOL, V82, P239-
hcfmusp.relation.referenceBraga-Neto U, 2004, PATTERN RECOGN, V37, P1267, DOI 10.1016/j.patcog.2003.08.017-
hcfmusp.relation.referenceBrooks WM, 2007, BRAIN RES, V1127, P127, DOI 10.1016/j.brainres.2006.09.106-
hcfmusp.relation.referenceBuchhave P, 2010, NEUROBIOL AGING, V31, P1877, DOI 10.1016/j.neurobiolaging.2008.10.012-
hcfmusp.relation.referenceBUXBAUM JD, 1992, P NATL ACAD SCI USA, V89, P10075, DOI 10.1073/pnas.89.21.10075-
hcfmusp.relation.referenceCenini G, 2008, J CELL MOL MED, V12, P987, DOI [10.1111/j.1582-4934.2008.00163.x, 10.1111/j.1582-4934.2007.00163.x]-
hcfmusp.relation.referenceCline MS, 2007, NAT PROTOC, V2, P2366, DOI 10.1038/nprot.2007.324-
hcfmusp.relation.referenceColangelo V, 2002, J NEUROSCI RES, V70, P462, DOI 10.1002/jnr.10351-
hcfmusp.relation.referenceCoppede F, 2009, CURR ALZHEIMER RES, V6, P36-
hcfmusp.relation.referenceCounts SE, 2007, ARCH NEUROL-CHICAGO, V64, P1771, DOI 10.1001/archneur.64.12.1771-
hcfmusp.relation.referenceDELBO R, 1995, NEUROSCI LETT, V188, P70, DOI 10.1016/0304-3940(95)11384-9-
hcfmusp.relation.referenceDiniz BS, 2010, J ALZHEIMERS DIS, V22, P1305, DOI 10.3233/JAD-2010-100921-
hcfmusp.relation.referenceEmilsson L, 2006, NEUROBIOL DIS, V21, P618, DOI 10.1016/j.nbd.2005.09.004-
hcfmusp.relation.referenceFagan AM, 2009, ANN NEUROL, V65, P176, DOI 10.1002/ana.21559-
hcfmusp.relation.referenceFagan AM, 2007, ARCH NEUROL-CHICAGO, V64, P343, DOI 10.1001/archneur.64.3.noc60123-
hcfmusp.relation.referenceFerretti REL, 2010, DEMENT NEUROPSYCHOL, V4, P138-
hcfmusp.relation.referenceForlenza OV, 2010, WORLD J BIOL PSYCHIA, V11, P774, DOI 10.3109/15622971003797241-
hcfmusp.relation.referenceForlenza OV, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-89-
hcfmusp.relation.referenceGalindo MF, 2010, J NEUROCHEM, V114, P933, DOI 10.1111/j.1471-4159.2010.06814.x-
hcfmusp.relation.referenceGattaz WF, 2004, J NEURAL TRANSM, V111, P591, DOI 10.1007/s00702-004-0142-y-
hcfmusp.relation.referenceGomes LI, 2003, ANAL BIOCHEM, V321, P244, DOI 10.1016/S0003-2697(03)00466-4-
hcfmusp.relation.referenceRavetti MG, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010153-
hcfmusp.relation.referenceGrinberg Lea Tenenholz, 2007, Cell and Tissue Banking, V8, P151, DOI 10.1007/s10561-006-9022-z-
hcfmusp.relation.referenceHARDY J, 1991, TRENDS PHARMACOL SCI, V12, P383, DOI 10.1016/0165-6147(91)90609-V-
hcfmusp.relation.referenceHardy J, 2002, SCIENCE, V297, P353, DOI 10.1126/science.1072994-
hcfmusp.relation.referenceHauptmann S, 2009, NEUROBIOL AGING, V30, P1574, DOI 10.1016/j.neurobiolaging.2007.12.005-
hcfmusp.relation.referenceHoyer S, 2004, ADV EXP MED BIOL, V541, P135-
hcfmusp.relation.referenceIqbal K, 2005, BBA-MOL BASIS DIS, V1739, P198, DOI 10.1016/j.bbadis.2004.09.008-
hcfmusp.relation.referenceJack CR, 2010, LANCET NEUROL, V9, P119, DOI 10.1016/S1474-4422(09)70299-6-
hcfmusp.relation.referenceKageyama R, 2008, DEV GROWTH DIFFER, V50, pS97, DOI 10.1111/j.1440-169X.2008.00993.x-
hcfmusp.relation.referenceKatsel P, 2007, NEUROCHEM RES, V32, P845, DOI 10.1007/s11064-007-9297-x-
hcfmusp.relation.referenceKerrien S, 2012, NUCLEIC ACIDS RES, V40, pD841, DOI 10.1093/nar/gkr1088-
hcfmusp.relation.referencePrasad TSK, 2009, NUCLEIC ACIDS RES, V37, pD767, DOI 10.1093/nar/gkn892-
hcfmusp.relation.referenceKim S, 2002, J COMPUT BIOL, V9, P127, DOI 10.1089/10665270252833226-
hcfmusp.relation.referenceKyo S, 2000, NUCLEIC ACIDS RES, V28, P669, DOI 10.1093/nar/28.3.669-
hcfmusp.relation.referenceLee W, 2004, MOL CELL NEUROSCI, V26, P222, DOI 10.1016/j.mcn.2003.10.020-
hcfmusp.relation.referenceLiang WS, 2010, NEUROBIOL AGING, V31, P549, DOI 10.1016/j.neurobiolaging.2008.05.013-
hcfmusp.relation.referenceLicata L, 2012, NUCLEIC ACIDS RES, V40, pD857, DOI 10.1093/nar/gkr930-
hcfmusp.relation.referenceLindberg C, 2005, J MOL NEUROSCI, V27, P1, DOI 10.1385/JMN:27:01:01-
hcfmusp.relation.referenceLiu Y, 2008, FEBS LETT, V582, P359, DOI 10.1016/j.febslet.2007.12.035-
hcfmusp.relation.referenceMCKHANN G, 1984, NEUROLOGY, V34, P939-
hcfmusp.relation.referenceMIRRA SS, 1991, NEUROLOGY, V41, P479-
hcfmusp.relation.referenceMormino EC, 2009, BRAIN, V132, P1310, DOI 10.1093/brain/awn320-
hcfmusp.relation.referenceMORRIS JC, 1993, NEUROLOGY, V43, P2412-
hcfmusp.relation.referenceNagasaka Y, 2005, P NATL ACAD SCI USA, V102, P14854, DOI 10.1073/pnas.0504178102-
hcfmusp.relation.referenceNeto ED, 2000, P NATL ACAD SCI USA, V97, P3491-
hcfmusp.relation.referenceParachikova A, 2007, NEUROBIOL AGING, V28, P1821, DOI 10.1016/j.neurobiolaging.2006.08.014-
hcfmusp.relation.referencePeng SW, 2010, BIOCHEM BIOPH RES CO, V393, P356, DOI 10.1016/j.bbrc.2009.12.122-
hcfmusp.relation.referencePodtelezhnikov AA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029610-
hcfmusp.relation.referencePollack J, 2003, DNA MICROARRAYS MOL, P168-
hcfmusp.relation.referencePrice JL, 1999, ANN NEUROL, V45, P358, DOI 10.1002/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X-
hcfmusp.relation.referencePrice JL, 2009, NEUROBIOL AGING, V30, P1026, DOI 10.1016/j.neurobiolaging.2009.04.002-
hcfmusp.relation.referencePrifti E, 2008, BIOINFORMATICS, V24, P2636, DOI 10.1093/bioinformatics/btn492-
hcfmusp.relation.referenceRay S, 2007, NAT MED, V13, P1359, DOI 10.1038/nm1653-
hcfmusp.relation.referenceSaeed AI, 2003, BIOTECHNIQUES, V34, P374-
hcfmusp.relation.referenceSchaub RT, 2002, AM J PSYCHIAT, V159, P1227, DOI 10.1176/appi.ajp.159.7.1227-
hcfmusp.relation.referenceSELKOE DJ, 1991, NEURON, V6, P487, DOI 10.1016/0896-6273(91)90052-2-
hcfmusp.relation.referenceSelkoe DJ, 2002, SCIENCE, V298, P789, DOI 10.1126/science.1074069-
hcfmusp.relation.referenceShankar GM, 2008, NAT MED, V14, P837, DOI 10.1038/nm1782-
hcfmusp.relation.referenceSheng JG, 2000, EXP NEUROL, V163, P388, DOI 10.1006/exnr.2000.7393-
hcfmusp.relation.referenceShiina N, 2005, J NEUROSCI, V25, P4420, DOI 10.1523/JNEUROSCI.0382-05.2005-
hcfmusp.relation.referenceSilva PJS, 2005, PATTERN RECOGN LETT, V26, P1444, DOI 10.1016/j.patrec.2004.11.017-
hcfmusp.relation.referenceSolomon S, 2007, MOL CELL BIOL, V27, P2324, DOI 10.1128/MCB.02300.06-
hcfmusp.relation.referenceSperling RA, 2011, ALZHEIMERS DEMENT, V7, P280, DOI 10.1016/j.jalz.2011.03.003-
hcfmusp.relation.referenceStern Y, 2006, ALZ DIS ASSOC DIS, V20, pS69, DOI 10.1097/00002093-200607001-00010-
hcfmusp.relation.referenceSwerdlow RH, 2004, MED HYPOTHESES, V63, P8, DOI 10.1016/j.mehy.2003.12.045-
hcfmusp.relation.referenceTaylor IW, 2009, NAT BIOTECHNOL, V27, P199, DOI 10.1038/nbt.1522-
hcfmusp.relation.referenceTERRY RD, 1991, ANN NEUROL, V30, P572, DOI 10.1002/ana.410300410-
hcfmusp.relation.referenceTomida J, 2008, J BIOL CHEM, V283, P9071, DOI 10.1074/jbc.M709835200-
hcfmusp.relation.referenceTomoda T, 2004, GENE DEV, V18, P541, DOI 10.1101/gad.1151204-
hcfmusp.relation.referenceTonks NK, 2006, NAT REV MOL CELL BIO, V7, P833, DOI 10.1038/nrm2039-
hcfmusp.relation.referenceVidal M, 2011, CELL, V144, P986, DOI 10.1016/j.cell.2011.02.016-
hcfmusp.relation.referenceVillemagne VL, 2008, NEUROPSYCHOLOGIA, V46, P1688, DOI 10.1016/j.neuropsychologia.2008.02.008-
hcfmusp.relation.referenceWang B, 2005, J IMMUNOL, V175, P4274-
hcfmusp.relation.referenceWilliams C, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004936-
hcfmusp.relation.referenceYang Y, 2007, BBA-MOL BASIS DIS, V1772, P457, DOI 10.1016/j.bbadis.2006.10.002-
hcfmusp.relation.referenceYang Y, 2003, J NEUROSCI, V23, P2557-
hcfmusp.relation.referenceYao PJ, 2003, NEUROBIOL DIS, V12, P97, DOI 10.1016/S0969-9961(02)0009-8-
hcfmusp.relation.referenceZhu GF, 2001, BIOCHEM BIOPH RES CO, V285, P997, DOI 10.1006/bbrc.2001.5273-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MPS
Departamento de Psiquiatria - FM/MPS

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/21
LIM/21 - Laboratório de Neuroimagem em Psiquiatria

Artigos e Materiais de Revistas Científicas - LIM/22
LIM/22 - Laboratório de Patolologia Cardiovascular

Files in This Item:
File Description SizeFormat 
art_FARFEL_Transcriptional_Alterations_Related_to_Neuropathology_and_Clinical_Manifestation_2012.PDFpublishedVersion (English)594.45 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.