https://observatorio.fm.usp.br/handle/OPI/47096
Título: | Evaluation of IFN-gamma secretion after stimulation with C. neoformans and C. gattii antigens in individuals with frequent exposure to the fungus |
Autor: | MACIEL, Isabel Feitosa; FREITAS-XAVIER, Roseli Santos de; VICENTINI, Adriana Pardini; APOLIANO, Carlos Fernando; FERNANDES, Juliana Ruiz; DIAS, Alana dos Santos; GIMENES, Viviane Favero Mazo; BENARD, Gil; VASCONCELOS, Dewton Moraes |
Citación: | JOURNAL DE MYCOLOGIE MEDICALE, v.32, n.2, article ID 101230, 5p, 2022 |
Resumen: | In this study we produced antigenic extracts from prototypical strains of C. neoformans (VNI-VNIV) and C. gattii (VGI-VGIV) and tested IFN-gamma secretion by Elispot. Antigens from the eight Cryptococcus molecular types (VNI -VNIV and VGI - VGIV) were obtained after capsule reduction. IFN-gamma secretion by Elispot method were stimulated with C. neoformans and C. gattii antigens. Peripheral blood mononuclear cells of fourteen healthy control subjects, being: five ecotourists, two mycologists, three poultry keepers, and four individuals without reports of exposure to the fungus. We observed a significant increase in IFN-gamma secretion in the group of ecotourists, mycologists and bird keepers in relation to the group of individuals without reports of occupational exposures to these agents. Our results suggest the significant increase in IFN-gamma secretion may be related to the continuous exposure of these groups of individuals to the fungus, as well as to the specific antigen memory immune response developed during exposure to Cryptococcus. |
Aparece en las colecciones: | Artigos e Materiais de Revistas Científicas - FM/MDT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - IMT Artigos e Materiais de Revistas Científicas - LIM/31 Artigos e Materiais de Revistas Científicas - LIM/36 Artigos e Materiais de Revistas Científicas - LIM/53 Artigos e Materiais de Revistas Científicas - LIM/56 Artigos e Materiais de Revistas Científicas - ODS/08 Artigos e Materiais de Revistas Científicas - ODS/12 |
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art_MACIEL_Evaluation_of_IFNgamma_secretion_after_stimulation_with_C_2022.PDF Restricted Access | publishedVersion (English) | 801.99 kB | Adobe PDF | Visualizar/Abrir Request a copy |
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