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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorMACIEL, Isabel Feitosa-
dc.contributor.authorFREITAS-XAVIER, Roseli Santos de-
dc.contributor.authorVICENTINI, Adriana Pardini-
dc.contributor.authorAPOLIANO, Carlos Fernando-
dc.contributor.authorFERNANDES, Juliana Ruiz-
dc.contributor.authorDIAS, Alana dos Santos-
dc.contributor.authorGIMENES, Viviane Favero Mazo-
dc.contributor.authorBENARD, Gil-
dc.contributor.authorVASCONCELOS, Dewton Moraes-
dc.date.accessioned2022-06-20T15:26:36Z-
dc.date.available2022-06-20T15:26:36Z-
dc.date.issued2022-
dc.identifier.citationJOURNAL DE MYCOLOGIE MEDICALE, v.32, n.2, article ID 101230, 5p, 2022-
dc.identifier.issn1156-5233-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/47096-
dc.description.abstractIn this study we produced antigenic extracts from prototypical strains of C. neoformans (VNI-VNIV) and C. gattii (VGI-VGIV) and tested IFN-gamma secretion by Elispot. Antigens from the eight Cryptococcus molecular types (VNI -VNIV and VGI - VGIV) were obtained after capsule reduction. IFN-gamma secretion by Elispot method were stimulated with C. neoformans and C. gattii antigens. Peripheral blood mononuclear cells of fourteen healthy control subjects, being: five ecotourists, two mycologists, three poultry keepers, and four individuals without reports of exposure to the fungus. We observed a significant increase in IFN-gamma secretion in the group of ecotourists, mycologists and bird keepers in relation to the group of individuals without reports of occupational exposures to these agents. Our results suggest the significant increase in IFN-gamma secretion may be related to the continuous exposure of these groups of individuals to the fungus, as well as to the specific antigen memory immune response developed during exposure to Cryptococcus.eng
dc.language.isoeng-
dc.publisherMASSON EDITEUReng
dc.relation.ispartofJournal de Mycologie Medicale-
dc.rightsrestrictedAccesseng
dc.subjectCryptococcus neoformanseng
dc.subjectCryptococcus gattiieng
dc.subjectIFN-gammaeng
dc.subject.othercryptococcus-neoformanseng
dc.subject.othercapsuleeng
dc.subject.othermannoproteineng
dc.titleEvaluation of IFN-gamma secretion after stimulation with C. neoformans and C. gattii antigens in individuals with frequent exposure to the funguseng
dc.typearticleeng
dc.rights.holderCopyright MASSON EDITEUReng
dc.identifier.doi10.1016/j.mycmed.2021.101230-
dc.identifier.pmid34923245-
dc.subject.wosMedicine, General & Internaleng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalFREITAS-XAVIER, Roseli Santos de:Univ Sao Paulo, Inst Med Trop Sao Paulo, Lab Micol Med, Fac Med, LIM 53, Sao Paulo, SP, Brazil-
hcfmusp.author.externalVICENTINI, Adriana Pardini:Adolfo Lutz Inst, Lab Imunodiagnost Micoses, Sao Paulo, SP, Brazil-
hcfmusp.author.externalAPOLIANO, Carlos Fernando:Univ Sao Paulo, Lab Imunol Imunodeficiencias Primarias & Secundar, Dept Dermatol, Hosp Clin,Fac Med, LIM 56,Av Dr Enaas de Carvalho Aguiar 470, BR-05403000 Sao Paulo, SP, Brazil-
hcfmusp.description.articlenumber101230-
hcfmusp.description.issue2-
hcfmusp.description.volume32-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000800535500010-
hcfmusp.origem.id2-s2.0-85121225830-
hcfmusp.publisher.cityMOULINEAUX CEDEX 9eng
hcfmusp.publisher.countryFRANCEeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1773-0449-
hcfmusp.citation.scopus0-
hcfmusp.scopus.lastupdate2022-09-06-
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ODS/12 - Consumo e produção responsáveis


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