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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorASSIS, Livia-
dc.contributor.authorMORETTI, Ana I. S.-
dc.contributor.authorABRAHAO, Thalita B.-
dc.contributor.authorCURY, Vivian-
dc.contributor.authorSOUZA, Heraldo P.-
dc.contributor.authorHAMBLIN, Michael R.-
dc.contributor.authorPARIZOTTO, Nivaldo A.-
dc.identifier.citationLASERS IN SURGERY AND MEDICINE, v.44, n.9, p.726-735, 2012-
dc.description.abstractBackground and Objective Muscle regeneration is a complex phenomenon, involving coordinated activation of several cellular responses. During this process, oxidative stress and consequent tissue damage occur with a severity that may depend on the intensity and duration of the inflammatory response. Among the therapeutic approaches to attenuate inflammation and increase tissue repair, low-level laser therapy (LLLT) may be a safe and effective clinical procedure. The aim of this study was to evaluate the effects of LLLT on oxidative/nitrative stress and inflammatory mediators produced during a cryolesion of the tibialis anterior (TA) muscle in rats. Material and Methods Sixty Wistar rats were randomly divided into three groups (n?=?20): control (BC), injured TA muscle without LLLT (IC), injured TA muscle submitted to LLLT (IRI). The injured region was irradiated daily for 4 consecutive days, starting immediately after the lesion using a AlGaAs laser (continuous wave, 808?nm, tip area of 0.00785?cm2, power 30?mW, application time 47?seconds, fluence 180?J/cm2; 3.8?mW/cm2; and total energy 1.4?J). The animals were sacrificed on the fourth day after injury. Results LLLT reduced oxidative and nitrative stress in injured muscle, decreased lipid peroxidation, nitrotyrosine formation and NO production, probably due to reduction in iNOS protein expression. Moreover, LLLT increased SOD gene expression, and decreased the inflammatory response as measured by gene expression of NF-k beta and COX-2 and by TNF-a and IL-1 beta concentration. Conclusion These results suggest that LLLT could be an effective therapeutic approach to modulate oxidative and nitrative stress and to reduce inflammation in injured muscle. Lasers Surg. Med. 44: 726735, 2012. (c) 2012 Wiley Periodicals, Inc.-
dc.description.sponsorshipNational Institutes of Health (NIH) [R01AI050875]-
dc.description.sponsorshipEmergency Medicine Division [FMUSP-HC/LIM-51]-
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2006/01096-8, 2009/01990-9]-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico (CNPq) [473537/2008-7, 151747/2007-5]-
dc.relation.ispartofLasers in Surgery and Medicine-
dc.subjectlow-level laser therapy-
dc.subjectmuscle cryolesion-
dc.subjectinflammatory mediators-
dc.subjectnitrative stress-
dc.subjectoxidative stress-
dc.subject.othertranscription factor-
dc.titleLow-level laser therapy (808 nm) reduces inflammatory response and oxidative stress in rat tibialis anterior muscle after cryolesion-
dc.rights.holderCopyright WILEY-BLACKWELL-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Livia:Univ Sao Paulo, Dept Phisiotherapy, Lab Electrothermophototherapy, Sao Carlos, SP, Brazil-, Michael R.:Massachusetts Gen Hosp, Wellman Labs Photomed, Boston, MA 02114 USA; Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA; Harvard MIT Div Hlth Sci & Technol, Cambridge, MA USA-, Nivaldo A.:Univ Sao Paulo, Dept Phisiotherapy, Lab Electrothermophototherapy, Sao Carlos, SP, Brazil-
hcfmusp.relation.referenceAdams V, 2002, CARDIOVASC RES, V54, P95, DOI 10.1016/S0008-6363(02)00228-6-
hcfmusp.relation.referenceAmaral AC, 2001, LASER MED SCI, V16, P44, DOI 10.1007/PL00011336-
hcfmusp.relation.referenceAssis L, 2012, LASERS MED SCI-
hcfmusp.relation.referenceBaptista J, 2011, PHOTOMED LASER SURG, V29, P11, DOI 10.1089/pho.2009.2737-
hcfmusp.relation.referenceBarnes PJ, 1997, NEW ENGL J MED, V336, P1066-
hcfmusp.relation.referenceBeckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424-
hcfmusp.relation.referenceBen-Dov N, 1999, BBA-MOL CELL RES, V1448, P372, DOI 10.1016/S0167-4889(98)00147-5-
hcfmusp.relation.referenceBjordal JM, 2010, PHYS THER REV, V15, P7-
hcfmusp.relation.referenceBuford TW, 2009, APPL PHYSIOL NUTR ME, V34, P745, DOI 10.1139/H09-067-
hcfmusp.relation.referenceChen ACH, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022453-
hcfmusp.relation.referenceCressoni MDC, 2008, PHOTOMED LASER SURG, V26, P461, DOI 10.1089/pho.2007.2150-
hcfmusp.relation.referenceDourado DM, 2003, LASER SURG MED, V33, P352, DOI 10.1002/lsm.10237-
hcfmusp.relation.referenceDouris P, 2006, PHOTOMED LASER SURG, V24, P377, DOI 10.1089/pho.2006.24.377-
hcfmusp.relation.referenceDroge W, 2002, PHYSIOL REV, V82, P47-
hcfmusp.relation.referenceEl-Remessy AB, 2007, FASEB J, V21, P2528, DOI 10.1096/fj.06-7854com-
hcfmusp.relation.referenceFilippin LI, 2011, INFLAMM RES, V60, P347, DOI 10.1007/s00011-010-0277-2-
hcfmusp.relation.referenceFilippin LI, 2009, NITRIC OXIDE, V21, P157-
hcfmusp.relation.referenceFillipin LI, 2005, LASER SURG MED, V37, P293, DOI 10.1002/lsm.20225-
hcfmusp.relation.referenceHamblin MR, 2010, LASER SURG MED, V42, P447, DOI 10.1002/lsm.20959-
hcfmusp.relation.referenceHuard J, 2002, J BONE JOINT SURG AM, V84A, P822-
hcfmusp.relation.referenceIyomasa DM, 2009, MICRON, V40, P413, DOI 10.1016/j.micron.2009.02.002-
hcfmusp.relation.referenceJarvinen TAHJ, 2005, AM J SPORT MED, V33, P745, DOI 10.1177/0363546505274714-
hcfmusp.relation.referenceKaminski HJ, 2001, NEUROMUSCULAR DISORD, V11, P517-
hcfmusp.relation.referenceKim YG, 2000, LASER SURG MED, V27, P420, DOI 10.1002/1096-9101(2000)27:5<420::AID-LSM1003>3.0.CO;2-K-
hcfmusp.relation.referenceKroncke KD, 2001, INT IMMUNOPHARMACOL, V1, P1407, DOI 10.1016/S1567-5769(01)00087-X-
hcfmusp.relation.referenceLangen RCJ, 2004, FASEB J, V18, P227, DOI 10.1096/fj.03-0251com-
hcfmusp.relation.referenceLeal ECP, 2010, J ORTHOP SPORT PHYS, V40, P524, DOI 10.2519/jospt.2010.3294-
hcfmusp.relation.referenceLi Y, 2001, CURR OPIN ORTHOP, V12, P6-
hcfmusp.relation.referenceLiu XG, 2009, PHOTOMED LASER SURG, V27, P863, DOI 10.1089/pho.2008.2443-
hcfmusp.relation.referenceLopes-Martins RAB, 2006, J APPL PHYSIOL, V101, P283, DOI 10.1152/japplphysiol.01318.2005-
hcfmusp.relation.referenceMesquita-Ferrari RA, 2011, LASER MED SCI, V26, P335, DOI 10.1007/s10103-010-0850-5-
hcfmusp.relation.referenceMiyabara EH, 2006, AM J PHYSIOL-CELL PH, V290, pC1128, DOI 10.1152/ajpcell.00399.2005.-
hcfmusp.relation.referenceNakano J, 2009, EXP PHYSIOL, V94, P1005, DOI 10.1113/expphysiol.2009.047738-
hcfmusp.relation.referencePallotta RC, 2012, LASER MED SCI, V27, P71, DOI 10.1007/s10103-011-0906-1-
hcfmusp.relation.referenceRamos L, 2012, PHOTOCHEM PHOTOBIOL, V88, P154, DOI 10.1111/j.1751-1097.2011.01030.x-
hcfmusp.relation.referenceRenno ACM, 2011, PHOTOMED LASER SURG, V29, P5, DOI 10.1089/pho.2009.2715-
hcfmusp.relation.referenceRizzi CF, 2006, LASER SURG MED, V38, P704, DOI 10.1002/lsm.20371-
hcfmusp.relation.referenceServetto N, 2010, LASER SURG MED, V42, P577, DOI 10.1002/lsm.20910-
hcfmusp.relation.referenceShefer G, 2001, J CELL PHYSIOL, V187, P73, DOI 10.1002/1097-4652(2001)9999:9999<::AID-JCP1053>3.0.CO;2-9-
hcfmusp.relation.referenceShi XZ, 2006, GENE DEV, V20, P1692, DOI 10.1101/gad.1419406-
hcfmusp.relation.referenceSilveira PCL, 2009, J PHOTOCH PHOTOBIO B, V95, P89, DOI 10.1016/j.jphotobiol.2009.01.004-
hcfmusp.relation.referenceTidball JG, 2005, AM J PHYSIOL-REG I, V288, pR345, DOI 10.1152/ajpregu.00454.2004-
hcfmusp.relation.referencevan den Berg R, 2001, BRIT J NUTR, V86, pS121, DOI 10.1079/BJN2001340-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/51
LIM/51 - Laboratório de Emergências Clínicas

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