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https://observatorio.fm.usp.br/handle/OPI/48457
Title: | Combined assessment by transcranial sonography and Sniffin' Sticks test has a similar diagnostic accuracy compared to brain SPECT for Parkinson's disease diagnosis. |
Authors: | ALMEIDA, Kelson James; BOR-SENG-SHU, Edson; PEDROSO, Jose Luiz; FELICIO, Andre Carvalho; DE-LIMA-OLIVEIRA, Marcelo; BARSOTTINI, Orlando Graziani Povoas; NOGUEIRA, Ricardo de Carvalho; PASCHOAL-JUNIOR, Fernando Mendes; BORGES, Vanderci; BATISTA, Ilza Rosa; TEIXEIRA, Manoel Jacobsen; FERRAZ, Henrique Ballalai; WALTER, Uwe |
Citation: | CLINICAL NEUROLOGY AND NEUROSURGERY, v.220, article ID 107333, 5p, 2022 |
Abstract: | Objectives: This study aimed to investigate the accuracy of TCS combined with the Sniffin' sticks olfactory test (SST-16) for differentiation between idiopathic PD patients and healthy controls compared to that of 99 mTc-TRODAT-1 SPECT (TRODAT). Methods: A cross-sectional study included PD patients diagnosed in accordance with United Kingdom PD Society Brain Bank criteria and a control group of age and sex-matched healthy subjects. All patients were examined by a movement disorder specialist and underwent brain SPECT using TRODAT, TCS examination and SST-16 test. Receiver Operating Characteristic (ROC) curves were used to calculate cut-off points for TCS, striatal TRODAT binding potentials and SST-16. The area under the ROC curve determined the diagnostic accuracy of the method. Results: Twenty patients with PD (13 males and 7 females) and nine healthy subjects were included. Median age of PD onset was 56.5 years with median disease duration of 5 years. A larger substantia nigra (SN) echogenic area was observed in the PD group (p = 0.013). SN echogenic area cut-off point of 0.22 cm2 was obtained from a ROC curve for PD diagnosis. Considering this cut-off point, TCS diagnostic accuracy was estimated at 79.2% for PD diagnosis. The cut-off value of 0.90 for striatal TRODAT binding was associated with 99% diagnostic accuracy for the diagnosis of PD. SST-16 values equal or less than 9 points showed an 85.8% diagnostic accuracy for PD diagnosis. Combination of both SST-16 and TCS improved the diagnostic accuracy to 95% for PD diagnosis. Conclusion: Combined SST-16 and TCS assessment was indicated as accurate for distinguishing PD patients from healthy controls. The diagnostic accuracy of TCS combined with SST-16 for differentiation between idiopathic PD patients and healthy controls is similar to that of SPECT TRODAT. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MNE Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/62 Artigos e Materiais de Revistas Científicas - ODS/10 |
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