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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | COSTA, Daniel L. C. | - |
dc.contributor.author | DINIZ, Juliana B. | - |
dc.contributor.author | JOAQUIM, Marines | - |
dc.contributor.author | BORCATO, Sonia R. | - |
dc.contributor.author | VALERIO, Carolina | - |
dc.contributor.author | MIGUEL, Euripedes C. | - |
dc.contributor.author | SHAVITT, Roseli G. | - |
dc.date.accessioned | 2014-02-17T20:55:48Z | - |
dc.date.available | 2014-02-17T20:55:48Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | BIOLOGICAL PSYCHIATRY, v.71, n.8, suppl.S, p.56S-57S, 2012 | - |
dc.identifier.issn | 0006-3223 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/4863 | - |
dc.description.abstract | Background: Delayed onset of response to serotonin reuptake inhibitors represents a challenge in obsessive-compulsive disorder (OCD) treatment. In depression, absence of improvement in the first weeks has been raised as a motive to switch antidepressants before full non-response is observed. We aimed to investigate if early improvement is a predictor of OCD outcome after 12 weeks. Methods: Participants (n=150) were admitted to a specialized OCD outpatient program. Inclusion criteria: age 18-65, DSM-IV diagnosis of OCD, minimum baseline Yale-Brown Obsessive Compulsive Scale(Y-BOCS) score of 16, absence of previous pharmacological treatment for OCD. Fluoxetine was used up to 80mg/day. Systematic assessments were taken at baseline, weeks 4 and 12. Non-improvement at 4-weeks was defined as no reduction of baseline Y-BOCS scores. Response at 12 weeks was defined as 35% or greater decrease in baseline Y-BOC score. Spearman correlation, linear regression and chi-square test were performed to test the relationship between improvement at 4-weeks and the 12-weeks outcome. Results: Mean Y-BOCS scores(SD) at baseline, 4 and 12 weeks were, respectively: 27.3(5.4), 22.8(6.9) and 20.8(8.3). Correlation coefficient for 4-weeks improvement and 12-weeks outcome was 0.43(p=0.01). Linear regression analysis showed no-effect of the covariates on 12-weeks outcome and confirmed the relationship between improvement at 4-weeks and outcome at 12 weeks (β coef= 0.44, p< 0.01). Only five (11.9%) non-responders at 4-weeks were responders at 12-weeks (Pearson Chi-Square= 9.1, p= 0.003). Conclusions: Early improvement predicted 12-weeks outcome of OCD, which may have a role in early decision-making in OCD treatment. | - |
dc.language.iso | eng | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.relation.ispartof | Biological Psychiatry | - |
dc.rights | restrictedAccess | - |
dc.subject | early improvement | - |
dc.subject | treatment response | - |
dc.subject | obsessive-compulsive disorder | - |
dc.subject | serotonin reuptake inhibitors | - |
dc.subject | predictors | - |
dc.title | Can Early Improvement be an Indicator of Treatment Response at Twelve Weeks in Obsessive Compulsive Disorder? Implications for Early-Treatment Decision-Making | - |
dc.type | conferenceObject | - |
dc.rights.holder | Copyright ELSEVIER SCIENCE INC | - |
dc.description.conferencedate | MAY 03-05, 2012 | - |
dc.description.conferencelocal | Philadelphia - PA, USA | - |
dc.description.conferencename | 67th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry | - |
dc.subject.wos | Neurosciences | - |
dc.subject.wos | Psychiatry | - |
dc.type.category | meeting abstract | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.beginpage | 56S | - |
hcfmusp.description.endpage | 57S | - |
hcfmusp.description.issue | 8 | - |
hcfmusp.description.issue | suppl S | - |
hcfmusp.description.volume | 71 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000302466000181 | - |
hcfmusp.publisher.city | NEW YORK | - |
hcfmusp.publisher.country | USA | - |
dc.description.index | MEDLINE | - |
Appears in Collections: | Comunicações em Eventos - FM/MPS Comunicações em Eventos - HC/IPq Comunicações em Eventos - LIM/21 |
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