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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorALVES JUNIOR, Jose Mario-
dc.contributor.authorBERNARDO, Wanderley Marques-
dc.contributor.authorWARD, Laura Sterian-
dc.contributor.authorVILLAGELIN, Danilo-
dc.identifier.citationFRONTIERS IN ENDOCRINOLOGY, v.13, article ID 800257, 10p, 2022-
dc.description.abstractContext: Although the overt hyperthyroidism treatment during pregnancy is mandatory, unfortunately, few studies have evaluated the impact of treatment on reducing maternal and fetal outcomes. Objective: This study aimed to demonstrate whether treatment to control hyperthyroidism manifested during pregnancy can potentially reduce maternal-fetal effects compared with euthyroid pregnancies through a systematic review with meta-analysis. Data Source: MEDLINE (PubMed), Embase, Cochrane Library Central, LILACS/BIREME until May 2021. Study Selection: Studies that compared, during the gestational period, treated women with hyperthyroidism versus euthyroid women. The following outcomes of this comparison were: pre-eclampsia, abruptio placentae, fetal growth retardation, gestational diabetes, postpartum hemorrhage, low birth weight, stillbirth, spontaneous abortions, premature birth. Data Extraction: Two independent reviewers extracted data and performed quality assessments. Dichotomous data were analyzed by calculating risk differences (DR) with fixed and random effect models according to the level of heterogeneity. Data Synthesis: Seven cohort studies were included. The results of the meta-analysis indicated that there was a lower incidence of preeclampsia (p=0.01), low birth weight (p=0.03), spontaneous abortion (p < 0.00001) and preterm birth (p=0.001) favouring the euthyroid pregnant group when compared to those who treated hyperthyroidism during pregnancy. However, no statistically significant differences were observed in the outcomes: abruptio placentae, fetal growth retardation, gestational diabetes mellitus, postpartum hemorrhage, and stillbirth. Conclusions: Our findings demonstrated that treating overt hyperthyroidism in pregnancy is mandatory and appears to reduce some potential maternal-fetal complications, despite there still being a residual risk of negative outcomes.eng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Endocrinology-
dc.subject.otheramerican thyroid associationeng
dc.subject.othersubclinical hyperthyroidismeng
dc.subject.otherplacental abruptioneng
dc.titleEffect of Hyperthyroidism Control During Pregnancy on Maternal and Fetal Outcome: A Systematic Review and Meta-Analysiseng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.subject.wosEndocrinology & Metabolismeng
dc.type.versionpublishedVersioneng JUNIOR, Jose Mario:Univ Estadual Campinas, Postgrad Course Internal Med, Campinas, Brazil-, Laura Sterian:Univ Estadual Campinas, Sch Med Sci, Lab Canc Mol Genet, Campinas, Brazil-, Danilo:Univ Estadual Campinas, Postgrad Course Internal Med, Campinas, Brazil; Univ Campinas PUC Campinas, Hosp Pontif Catholic, Endocrinol & Metab, Campinas, Brazil-
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Artigos e Materiais de Revistas Científicas - HC/Outros
Outros institutos - HC/Outros

Artigos e Materiais de Revistas Científicas - LIM/47
LIM/47 - Laboratório de Hepatologia por Vírus

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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