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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorANDERSON, Peter L.-
dc.contributor.authorGLIDDEN, David V.-
dc.contributor.authorLIU, Albert-
dc.contributor.authorBUCHBINDER, Susan-
dc.contributor.authorLAMA, Javier R.-
dc.contributor.authorGUANIRA, Juan Vicente-
dc.contributor.authorMCMAHAN, Vanessa-
dc.contributor.authorBUSHMAN, Lane R.-
dc.contributor.authorCASAPIA, Martin-
dc.contributor.authorMONTOYA-HERRERA, Orlando-
dc.contributor.authorVELOSO, Valdilea G.-
dc.contributor.authorMAYER, Kenneth H.-
dc.contributor.authorCHARIYALERTSAK, Suwat-
dc.contributor.authorSCHECHTER, Mauro-
dc.contributor.authorBEKKER, Linda-Gail-
dc.contributor.authorKALLAS, Esper Georges-
dc.contributor.authorGRANT, Robert M.-
dc.date.accessioned2013-07-30T14:41:57Z-
dc.date.available2013-07-30T14:41:57Z-
dc.date.issued2012-
dc.identifier.citationSCIENCE TRANSLATIONAL MEDICINE, v.4, n.151, article ID 151ra125, 8p, 2012-
dc.identifier.issn1946-6234-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/502-
dc.description.abstractDrug concentrations associated with protection from HIV-1 acquisition have not been determined. We evaluated drug concentrations among men who have sex with men in a substudy of the iPrEx trial (1). In this randomized placebo-controlled trial, daily oral doses of emtricitabine/tenofovir disoproxil fumarate were used as pre-exposure prophylaxis (PrEP) in men who have sex with men. Drug was detected less frequently in blood plasma and in viable cryopreserved peripheral blood mononuclear cells (PBMCs) in HIV-infected cases at the visit when HIV was first discovered compared with controls at the matched time point of the study (8% versus 44%; P < 0.001) and in the 90 days before that visit (11% versus 51%; P < 0.001). An intracellular concentration of the active form of tenofovir, tenofovir-diphosphate (TFV-DP), of 16 fmol per million PBMCs was associated with a 90% reduction in HIV acquisition relative to the placebo arm. Directly observed dosing in a separate study, the STRAND trial, yielded TFV-DP concentrations that, when analyzed according to the iPrEx model, corresponded to an HIV-1 risk reduction of 76% for two doses per week, 96% for four doses per week, and 99% for seven doses per week. Pro-phylactic benefits were observed over a range of doses and drug concentrations, suggesting ways to optimize PrEP regimens for this population.-
dc.description.sponsorshipNational Institutes of Health (NIH) [R21MH085598, UO1 AI084735, RO1 AI062333, UO1 AI064002, UL1 RR024131]-
dc.language.isoeng-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.relation.ispartofScience Translational Medicine-
dc.rightsrestrictedAccess-
dc.subject.otherhiv prevention-
dc.subject.otherinfection-
dc.subject.otherplasma-
dc.titleEmtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men-
dc.typearticle-
dc.rights.holderCopyright AMER ASSOC ADVANCEMENT SCIENCE-
dc.contributor.groupauthoriPrEx Study Team-
dc.identifier.doi10.1126/scitranslmed.3004006-
dc.identifier.pmid22972843-
dc.subject.wosCell Biology-
dc.subject.wosMedicine, Research & Experimental-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalANDERSON, Peter L.:Univ Colorado Denver, Aurora, CO 80045 USA-
hcfmusp.author.externalGLIDDEN, David V.:Univ Calif San Francisco, San Francisco, CA 94143 USA-
hcfmusp.author.externalLIU, Albert:San Francisco Dept Publ Hlth, HIV Res Sect, San Francisco, CA 94102 USA-
hcfmusp.author.externalBUCHBINDER, Susan:Univ Calif San Francisco, San Francisco, CA 94143 USA; San Francisco Dept Publ Hlth, HIV Res Sect, San Francisco, CA 94102 USA-
hcfmusp.author.externalLAMA, Javier R.:Invest Med Salud, Lima 14, Peru; Asociac Civil Impacta Salud & Educ, Lima, Peru-
hcfmusp.author.externalGUANIRA, Juan Vicente:Asociac Civil Impacta Salud & Educ, Lima, Peru-
hcfmusp.author.externalMCMAHAN, Vanessa:Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA-
hcfmusp.author.externalBUSHMAN, Lane R.:Univ Colorado Denver, Aurora, CO 80045 USA-
hcfmusp.author.externalCASAPIA, Martin:Asociac Civil Selva Amazon, Iquitos, Maynas, Peru-
hcfmusp.author.externalMONTOYA-HERRERA, Orlando:Fdn Ecuatoriana Equidad, Guayaquil, Ecuador-
hcfmusp.author.externalVELOSO, Valdilea G.:Fundacao Oswaldo Cruz, Inst Pesquisa Clin Evandro Chagas, BR-21040900 Rio De Janeiro, Brazil-
hcfmusp.author.externalMAYER, Kenneth H.:Brown Univ, Providence, RI 02912 USA; Fenway Inst, Boston, MA 02215 USA-
hcfmusp.author.externalCHARIYALERTSAK, Suwat:Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50200, Thailand-
hcfmusp.author.externalSCHECHTER, Mauro:Univ Fed Rio de Janeiro, Projeto Praca Onze, Hosp Escola Sao Francisco de Assis, BR-20210030 Rio De Janeiro, Brazil-
hcfmusp.author.externalBEKKER, Linda-Gail:Univ Cape Town, Desmond Tutu HIV Ctr, ZA-7925 Cape Town, South Africa; Univ Cape Town, Dept Med, ZA-7925 Cape Town, South Africa-
hcfmusp.author.externalGRANT, Robert M.:Univ Calif San Francisco, San Francisco, CA 94143 USA; Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA-
hcfmusp.description.articlenumber151ra125-
hcfmusp.description.issue151-
hcfmusp.description.volume4-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84866283847-
hcfmusp.origem.idWOS:000308806000004-
hcfmusp.publisher.cityWASHINGTON-
hcfmusp.publisher.countryUSA-
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dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipNIH-
hcfmusp.lim.ref2012-
hcfmusp.citation.scopus620-
hcfmusp.scopus.lastupdate2022-05-20-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/60
LIM/60 - Laboratório de Imunologia Clínica e Alergia


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