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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | Reis, Fernando M. | - |
dc.contributor.author | Luisi, Stefano | - |
dc.contributor.author | Abrao, Mauricio S. | - |
dc.contributor.author | Rocha, Ana Luiza L. | - |
dc.contributor.author | Vigano, Paola | - |
dc.contributor.author | Rezende, Carolina P. | - |
dc.contributor.author | Florio, Pasquale | - |
dc.contributor.author | Petraglia, Felice | - |
dc.date.accessioned | 2014-02-25T14:56:08Z | - |
dc.date.available | 2014-02-25T14:56:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | HUMAN REPRODUCTION, v.27, n.5, p.1445-1450, 2012 | - |
dc.identifier.issn | 0268-1161 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/5032 | - |
dc.description.abstract | Activin A is a growth factor, produced by the endometrium, whose actions are modulated by the binding protein follistatin. Both proteins are detectable in the peripheral serum and their concentrations may be increased in women with endometriosis. The present study was designed to evaluate whether serum levels of activin A and follistatin are altered, and therefore have a potential diagnostic value, in women with peritoneal, ovarian and deep infiltrating endometriosis. We performed a multicenter controlled study evaluating simultaneously serum activin A and follistatin concentrations in women with and without endometriosis. Women with endometriosis (n 139) were subdivided into three groups: peritoneal endometriosis (n 28); ovarian endometrioma (n 61) and deep infiltrating endometriosis (n 50). The control group (n 75) consisted of healthy women with regular menstrual cycles. Blood samples were collected from a peripheral vein and assayed for activin A and follistatin using commercially available enzyme immunoassay kits. The ovarian endometrioma group had serum activin A levels significantly higher than healthy controls (0.22 0.01 ng/ml versus 0.17 0.01 ng/ml, P 0.01). None of the endometriosis groups had serum follistatin levels which were significantly altered compared with healthy controls; however, levels found in the endometrioma group (2.34 0.32 ng/ml) were higher than that in the deep endometriosis group (1.50 0.17 ng/ml, P 0.05). The area under the receiver operating characteristic curve of activin A was 0.700 (95 confidence interval: 0.6050.794), while that of follistatin was 0.620 (95 confidence interval: 0.5100.730) for the diagnosis of ovarian endometrioma. The combination of both markers into a duo marker index did not improve significantly their diagnostic accuracy. The present study demonstrated that serum activin A and follistatin are not significantly altered in peritoneal or deep infiltrating endometriosis and have limited diagnostic accuracy in the diagnosis of ovarian endometrioma. | - |
dc.description.sponsorship | Italian Ministry of University and Scientific Research (MURST) | - |
dc.description.sponsorship | University of Siena | - |
dc.description.sponsorship | Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil) | - |
dc.language.iso | eng | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.relation.ispartof | HUMAN REPRODUCTION | - |
dc.rights | restrictedAccess | - |
dc.subject | endometriosis | - |
dc.subject | endometrium | - |
dc.subject | inhibins and activins | - |
dc.subject.other | MENSTRUAL-CYCLE | - |
dc.subject.other | NONINVASIVE DIAGNOSIS | - |
dc.subject.other | EXPRESSION | - |
dc.subject.other | INHIBIN | - |
dc.subject.other | SUBUNITS | - |
dc.subject.other | INFERTILITY | - |
dc.subject.other | BIOMARKERS | - |
dc.subject.other | RECEPTORS | - |
dc.subject.other | SECRETION | - |
dc.subject.other | PREGNANCY | - |
dc.title | Diagnostic value of serum activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis | - |
dc.type | article | - |
dc.rights.holder | Copyright OXFORD UNIV PRESS | - |
dc.identifier.doi | 10.1093/humrep/des055 | - |
dc.identifier.pmid | 22416010 | - |
dc.subject.wos | Obstetrics & Gynecology | - |
dc.subject.wos | Reproductive Biology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | Reis, Fernando M.: Univ Minas Gerais, Dept Obstet & Gynecol, Belo Horizonte, MG, Brazil; Natl Inst Hormones & Womens Hlth, Belo Horizonte, MG, Brazil | - |
hcfmusp.author.external | Rocha, Ana Luiza L.: Univ Siena, Dept Pediat Obstet & Reprod Med, I-53100 Siena, Italy; Univ Minas Gerais, Dept Obstet & Gynecol, Belo Horizonte, MG, Brazil; Natl Inst Hormones & Womens Hlth, Belo Horizonte, MG, Brazil | - |
hcfmusp.author.external | Luisi, Stefano: Univ Siena, Dept Pediat Obstet & Reprod Med, I-53100 Siena, Italy | - |
hcfmusp.author.external | Vigano, Paola: Ist Sci San Raffaele, Obstet & Gynecol Unit, I-20132 Milan, Italy | - |
hcfmusp.author.external | Rezende, Carolina P.: Univ Minas Gerais, Dept Obstet & Gynecol, Belo Horizonte, MG, Brazil; Natl Inst Hormones & Womens Hlth, Belo Horizonte, MG, Brazil | - |
hcfmusp.author.external | Florio, Pasquale: Univ Siena, Dept Pediat Obstet & Reprod Med, I-53100 Siena, Italy | - |
hcfmusp.author.external | Petraglia, Felice: Univ Siena, Dept Pediat Obstet & Reprod Med, I-53100 Siena, Italy | - |
hcfmusp.description.beginpage | 1445 | - |
hcfmusp.description.endpage | 1450 | - |
hcfmusp.description.issue | 5 | - |
hcfmusp.description.volume | 27 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84860123476 | - |
hcfmusp.origem.id | WOS:000303161900026 | - |
hcfmusp.publisher.city | OXFORD | - |
hcfmusp.publisher.country | ENGLAND | - |
hcfmusp.relation.reference | Abrao MS, 1997, HUM REPROD, V12, P2523, DOI 10.1093/humrep/12.11.2523 | - |
hcfmusp.relation.reference | [Anonymous], 1997, FERTIL STERIL, V67, P817 | - |
hcfmusp.relation.reference | Bulun SE, 2009, NEW ENGL J MED, V360, P268, DOI 10.1056/NEJMra0804690 | - |
hcfmusp.relation.reference | Carneiro MM, 2010, J ENDOMETRIOSIS, V2, P63 | - |
hcfmusp.relation.reference | Chapron C, 2003, HUM REPROD, V18, P760, DOI 10.1093/humrep/deg152 | - |
hcfmusp.relation.reference | Cheng YM, 2002, OBSTET GYNECOL, V99, P375, DOI 10.1016/S0029-7844(01)01731-8 | - |
hcfmusp.relation.reference | deWinter JP, 1996, EXP CELL RES, V224, P323, DOI 10.1006/excr.1996.0142 | - |
hcfmusp.relation.reference | de Ziegler D, 2010, LANCET, V376, P730, DOI 10.1016/S0140-6736(10)60490-4 | - |
hcfmusp.relation.reference | Djalali S, 2009, J ENDOMETRIOSIS, V1, P46 | - |
hcfmusp.relation.reference | Duleba AJ, 1997, OBSTET GYN CLIN N AM, V24, P331, DOI 10.1016/S0889-8545(05)70307-7 | - |
hcfmusp.relation.reference | Flahault A, 2005, J CLIN EPIDEMIOL, V58, P859, DOI 10.1016/j.jclinepi.2004.12.009 | - |
hcfmusp.relation.reference | Florio P, 2009, HUM REPROD, V24, P2600, DOI 10.1093/humrep/dep195 | - |
hcfmusp.relation.reference | Florio P, 2003, J SOC GYNECOL INVEST, V10, P237, DOI 10.1016/S1071-5576(03)00045-5 | - |
hcfmusp.relation.reference | Florio P, 2004, MOL CELL ENDOCRINOL, V218, P129, DOI 10.1016/j.mce.2003.12.019 | - |
hcfmusp.relation.reference | Florio P, 1998, HUM REPROD, V13, P2606, DOI 10.1093/humrep/13.9.2606 | - |
hcfmusp.relation.reference | Giudice LC, 2010, NEW ENGL J MED, V362, P2389, DOI 10.1056/NEJMcp1000274 | - |
hcfmusp.relation.reference | Giudice LC, 2004, LANCET, V364, P1789, DOI 10.1016/S0140-6736(04)17403-5 | - |
hcfmusp.relation.reference | HANLEY JA, 1983, RADIOLOGY, V148, P839 | - |
hcfmusp.relation.reference | Jones RL, 2002, MOL HUM REPROD, V8, P363, DOI 10.1093/molehr/8.4.363 | - |
hcfmusp.relation.reference | Jones RL, 2000, MOL HUM REPROD, V6, P1107, DOI 10.1093/molehr/6.12.1107 | - |
hcfmusp.relation.reference | Kamergorodsky G, 2009, FERTIL STERIL, V92, P2074, DOI 10.1016/j.fertnstert.2009.05.086 | - |
hcfmusp.relation.reference | Kitawaki J, 2005, HUM REPROD, V20, P1999, DOI 10.1093/humrep/deh890 | - |
hcfmusp.relation.reference | Leung PHY, 1998, HUM REPROD, V13, P3469, DOI 10.1093/humrep/13.12.3469 | - |
hcfmusp.relation.reference | May KE, 2010, HUM REPROD UPDATE, V16, P651, DOI 10.1093/humupd/dmq009 | - |
hcfmusp.relation.reference | Mihalyi A, 2010, HUM REPROD, V25, P654, DOI 10.1093/humrep/dep425 | - |
hcfmusp.relation.reference | Patrelli TS, 2011, FERTIL STERIL, V95, P393, DOI 10.1016/j.fertnstert.2010.08.043 | - |
hcfmusp.relation.reference | Prakash A, 2006, FERTIL STERIL, V86, P1723, DOI 10.1016/j.fertnstert.2006.05.040 | - |
hcfmusp.relation.reference | Reis FM, 2007, REPROD SCI, V14, P383, DOI 10.1177/1933719107303985 | - |
hcfmusp.relation.reference | Reis FM, 2001, FERTIL STERIL, V75, P367, DOI 10.1016/S0015-0282(00)01720-9 | - |
hcfmusp.relation.reference | Rocha ALL, 2011, FERTIL STERIL, V95, P2241, DOI 10.1016/j.fertnstert.2011.03.048 | - |
hcfmusp.relation.reference | Rogers PAW, 2009, REPROD SCI, V16, P335, DOI 10.1177/1933719108330568 | - |
hcfmusp.relation.reference | Rombauts L, 2006, AUST NZ J OBSTET GYN, V46, P148, DOI 10.1111/j.1479-828X.2006.00546.x | - |
hcfmusp.relation.reference | Schneyer A, 2004, MOL CELL ENDOCRINOL, V225, P25, DOI 10.1016/j.mce.2004.02.009 | - |
hcfmusp.relation.reference | Somigliana E, 2010, HUM REPROD, V25, P1863, DOI 10.1093/humrep/deq141 | - |
hcfmusp.relation.reference | Torres PB, 2007, FERTIL STERIL, V88, P200, DOI 10.1016/j.fertnstert.2006.11.105 | - |
hcfmusp.relation.reference | UENO N, 1987, P NATL ACAD SCI USA, V84, P8282, DOI 10.1073/pnas.84.23.8282 | - |
hcfmusp.relation.reference | Vercellini P, 2009, HUM REPROD UPDATE, V15, P177, DOI 10.1093/humupd/dmn062 | - |
hcfmusp.relation.reference | Vercellini P, 2009, HUM REPROD, V24, P254, DOI 10.1093/humrep/den379 | - |
hcfmusp.relation.reference | ZAR J. H., 1996, BIOSTATISTICAL ANAL | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CAPES | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 33 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOG Artigos e Materiais de Revistas Científicas - LIM/58 |
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