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Title: The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study
Authors: SILVA JR., Joao M.OLIVEIRA, Amanda Maria Ribas Rosa deNOGUEIRA, Fernando Augusto MendesVIANNA, Pedro Monferrari MonteiroPEREIRA FILHO, Marcos CruzDIAS, Leandro FerreiraMAIA, Vivian Paz LeaoNEUCAMP, Cesar de SouzaAMENDOLA, Cristina PrataCARMONA, Maria Jose CarvalhoMALBOUISSON, Luiz M. Sa
Citation: CRITICAL CARE, v.17, n.6, article ID R288, 7p, 2013
Abstract: Introduction: In some studies including small populations of patients undergoing specific surgery, an intraoperative liberal infusion of fluids was associated with increasing morbidity when compared to restrictive strategies. Therefore, to evaluate the role of excessive fluid infusion in a general population with high-risk surgery is very important. The aim of this study was to evaluate the impact of intraoperative fluid balance on the postoperative organ dysfunction, infection and mortality rate. Methods: We conducted a prospective cohort study during one year in four ICUs from three tertiary hospitals, which included patients aged 18 years or more who required postoperative ICU after undergoing major surgery. Patients who underwent palliative surgery and whose fluid balance could change in outcome were excluded. The calculation of fluid balance was based on preoperative fasting, insensible losses from surgeries and urine output minus fluid replacement intraoperatively. Results: The study included 479 patients. Mean age was 61.2 +/- 17.0 years and 8.8% of patients died at the hospital during the study. The median duration of surgery was 4.0 (3.2 to 5.5) h and the value of the Simplified Acute Physiology Score (SAPS) 3 score was 41.8 +/- 14.5. Comparing survivors and non-survivors, the intraoperative fluid balance from non-survivors was higher (1,950 (1,400 to 3,400) mL vs. 1,400 (1,000 to 1,600) mL, P < 0.001). Patients with fluid balance above 2,000 mL intraoperatively had a longer ICU stay (4.0 (3.0 to 8.0) vs. 3.0 (2.0 to 6.0), P < 0.001) and higher incidence of infectious (41.9% vs. 25.9%, P = 0.001), neurological (46.2% vs. 13.2%, P < 0.001), cardiovascular (63.2% vs. 39.6%, P < 0.001) and respiratory complications (34.3% vs. 11.6%, P < 0.001). In multivariate analysis, the fluid balance was an independent factor for death (OR per 100 mL = 1.024; P = 0.006; 95% CI 1.007 to 1.041). Conclusions: Patients with excessive intraoperative fluid balance have more ICU complications and higher hospital mortality.
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Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/08
LIM/08 - Laboratório de Anestesiologia

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