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Title: Production of the First Effective Hyperimmune Equine Serum Antivenom against Africanized Bees
Authors: SANTOS, Keity SouzaSTEPHANO, Marco AntonioMARCELINO, Jose RobertoFERREIRA, Virginia Maria ResendeROCHA, ThalitaCARICATI, CelsoHIGASHI, Hisako GondoMORO, Ana MariaKALIL, Jorge EliasMALASPINA, OsmarCASTRO, Fabio Fernandes MoratoPALMA, Mario Sergio
Citation: PLOS ONE, v.8, n.11, article ID e79971, 10p, 2013
Abstract: Victims of massive bee attacks become extremely ill, presenting symptoms ranging from dizziness and headache to acute renal failure and multiple organ failure that can lead to death. Previous attempts to develop specific antivenom to treat these victims have been unsuccessful. We herein report a F(ab)'(2)-based antivenom raised in horse as a potential new treatment for victims of multiple bee stings. The final product contains high specific IgG titers and is effective in neutralizing toxic effects, such as hemolysis, cytotoxicity and myotoxicity. The assessment of neutralization was revised and hemolysis, the primary toxic effect of these stings, was fully neutralized in vivo for the first time.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/19
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular

Artigos e Materiais de Revistas Científicas - LIM/60
LIM/60 - Laboratório de Imunologia Clínica e Alergia

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